Abstract: Provided herein are compositions and methods for ablating intracellular signaling through specific reactive oxygen species (ROS)-responsive effector proteins as means of treatment for various conditions of a pro-inflammatory character. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: The present disclosure generally relates to techniques for providing input mechanisms.

Abstract: Provided herein are compositions and methods for ablating intracellular signaling through specific cell surface receptors as means of treatment for various conditions of a pro-inflammatory character. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint. In some aspects, the compositions and method are for treating or preventing localized nociception, inflammation, degeneration, or morphological changes associated with back or spine conditions or disorders.

Abstract: Provided herein are compositions and methods for treating musculoskeletal fibrosis and/or scarring by ablating intracellular signaling through specific cell surface receptors through genetic editing. In some aspects, the compositions and methods are directed to the TGFB1 ligand. In other aspects, the compositions and methods are directed to the TGFB1 receptors (TGFBR1/TGFBR2). In some aspects, the compositions and method are to treat or prevent post-trauma fibrosis and/or scarring. In some aspects, the compositions and method are to treat or prevent postoperative fibrosis and/or scarring. In some aspects, the compositions and method are for treating or preventing localized nociception, inflammation, degeneration, or morphological changes associated with fibrosis and/or scarring.

Abstract: The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: The present disclosure generally relates user interfaces and techniques for providing navigation assistance in accordance with some embodiments, such as configuring a moveable computer system, selectively modifying a movement component of a moveable computer system based on a current mode, providing feedback based on an orientation of a movable computer system, and/or redirecting a movable computer system.

Abstract: In some embodiments, an electronic device navigates and/or travels using predetermined paths and/or impromptu paths. In some embodiments, the electronic device generates the impromptu paths based on characteristics, criteria, and/or factors relating to the environment of the electronic device. In some embodiments, the electronic device outputs indications of impromptu paths to be used for navigating and/or traveling.

Abstract: A system may include a display having a housing, a cover lens coupled to the housing, a light plate assembly in the housing, a diffuser that overlaps the light plate assembly, a louver layer that overlaps the diffuser, and a ring light source that emits additional light around the periphery of the light plate assembly and through the cover lens. The light plate assembly may include an array of light-emitting components. To improve the efficiency and contrast of the light plate assembly, reflective fill material may be formed around each light-emitting component, and absorptive fill material may surround the reflective fill material. The absorptive fill material may absorb ambient light, while the reflective fill material may redirect stray light out of the display. Dam material may surround the absorptive fill material and/or the reflective fill material.

Abstract: Based on a cost function that estimates a value of a confidence level above a confidence threshold using user information, an autonomous control system can determine that a user of a user device is ready for a pickup, identify a pickup location based on the user information, and determine a trajectory from a current location to the pickup location. A propulsion system is configured to cause motion current location toward the pickup location according to the trajectory.

Abstract: An actuator transfer assembly comprising an actuator (18), a driven object (16, 116), a pushrod (19) or shaft (119), a disconnect housing (24, 124), a transfer member (50) movable relative to the housing from a first position in mechanical engagement with the pushrod or shaft such that the housing translates or rotates with the pushrod or shaft and a second position in mechanical disengagement from the pushrod or shaft such that the housing does not translate or rotate with the pushrod or shaft, a bias element (34) biasing the transfer member towards the first position, and a retainer (44, 53) configured to automatically retain the transfer member in the second position when the transfer member moves from the first position, wherein the transfer member is configured to move from the first position to the second position when a force on the pushrod or a torque on the shaft exceeds a predetermined threshold breakout force or torque.

Abstract: A vehicle may have devices such as knobs, sliders, touch sensors, cameras, and other devices for gathering user input, capturing images, and gathering other information. Control circuitry in the vehicle may display an interactive route map on a display in the vehicle body. The route map may have a route line depicting a route between a starting point and an ending point for a journey. The control circuitry may move a vehicle icon in forward and reverse along the route line in response to the user input to select a vehicle icon location. The control circuitry may display media that corresponds to the selected vehicle icon location. The media may include an image captured by the camera, media retrieved from remote databases, and/or other content associated with the location of the vehicle icon.

Abstract: A power ecosystem is disclosed that includes a premises power interface associated with a premises, a moving object power interface associated with a moving object, and an accessory power pack comprising an accessory sensor. The accessory power pack is configured to receive an electrical charge from the premises power interface, supply an electrical charge to the moving object power interface, and be releasably secured to the moving object. The accessory power pack is configured to send accessory sensor information captured by the accessory sensor to at least one of the premises or the moving object.

Abstract: A process for making modified diethylenetriaminepentaacetic acid (DTPA)-associated media for use in solid-liquid extraction of rare earth elements is disclosed. The process includes functionalizing DTPA with hydrophobic groups to form modified DTPA; dissolving the modified DTPA into a methanol solution; loading the modified DTPA solution to a solid support; rotating the modified DTPA-loaded solid support to allow for association; and removing the methanol to obtain the modified-DTPA-associated media.

Abstract: A first input to a mobile device indicates a first navigation destination at a first level of specificity. The mobile device initiates navigation towards a first location corresponding to the first navigation destination. While navigation towards the first location corresponding to the first navigation destination is ongoing and before reaching the first location, in accordance with a determination that one or more first criteria are satisfied, the mobile device prompts for an input for determination a second location corresponding to a second navigation destination with a second level of specificity, the second level of specificity more specific than the first level of specificity. The mobile device receives a second input in response to the prompt. In accordance with a determination that the second input satisfies one or more second criteria, the mobile device initiates navigation towards the second location corresponding to the second navigation destination.

Abstract: The present disclosure provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: The present disclosure provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: A process for making modified diethylenetriaminepentaacetic acid (DTPA)-associated media for use in solid-liquid extraction of rare earth elements is disclosed. The process includes functionalizing DTPA with hydrophobic groups to form modified DTPA; dissolving the modified DTPA into a methanol solution; loading the modified DTPA solution to a solid support; rotating the modified DTPA-loaded solid support to allow for association; and removing the methanol to obtain the modified-DTPA-associated media.

Abstract: The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Abstract: A mobile ecosystem is disclosed that includes a vehicle with an autonomous control system configured to obtain vehicle information including a vehicle location of the vehicle and obtain user information including a user location of a user device. Based on a cost function that estimates a value of a confidence level above a confidence threshold using the user information, the autonomous control system can determine that a user of the user device is ready for a pickup by the vehicle, identify a pickup location for the vehicle based on the user information and the vehicle information, and determine a trajectory from the vehicle location to the pickup location. The vehicle includes a propulsion system configured to cause motion of the vehicle from the vehicle location toward the pickup location according to the trajectory.