Patents by Inventor Matthew J. Cunningham

Matthew J. Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (SINA)
    Publication number: 20240287515
    Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
    Type: Application
    Filed: January 19, 2024
    Publication date: August 29, 2024
    Inventors: Mark Cancilla, James John Cunningham, William Michael Flanagan, Henry J. Haringsma, Denise M. Kenski, Matthew G. Stanton, Steven M. Stirdivant, Aarron T. Willingham
  • RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
    Publication number: 20240247271
    Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.
    Type: Application
    Filed: September 15, 2023
    Publication date: July 25, 2024
    Inventors: Duncan Brown, James J. Cunningham, Marian Gindy, Victoria Pickering, Matthew G. Stanton, Steven M. Stirdivant, Walter R. Strapps
  • Vibratory flowmeter and methods and diagnostics for meter verification
    Patent number: 12038317
    Abstract: A vibratory flowmeter (5) for meter verification is provided, including meter electronics (20) coupled to the first and second pickoff sensors (170L, 170R) and coupled to a driver (180), with the meter electronics (20) configured to: vibrate the flowmeter assembly (10) in a single mode using the driver (180), determine a single mode current (230) of the driver (180) and determine first and second response voltages (231) generated by the first and second pickoff sensors (170L, 170R), respectively, compute frequency response functions for the determined first and second response voltages (231) from the determined single mode current (230), fit the generated frequency response functions to a pole-residue model, and verify proper operation of the vibratory flowmeter (5) using the meter stiffness value (216), residual flexibility (218), and the meter mass (240) in embodiments.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: July 16, 2024
    Assignee: Micro Motion, Inc.
    Inventors: Timothy J. Cunningham, David J. Kapolnek, Matthew J. Rensing, Christopher George Larsen
  • Continuous volume detection for a reservoir in a fluid circuit of a medical system
    Patent number: 7611478
    Abstract: Continuous volume detection for a reservoir in a fluid circuit of a medical system is described. Volume detection is based on a pressure measurement that is manipulated via application of fluid mechanics. Next-generation medical system controllers may use this data to control the volume contained in the reservoir.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: November 3, 2009
    Assignee: Minnetronix Inc.
    Inventors: Lori E. Lucke, Matthew J. Cunningham, Richard A. Nazarian
  • CONTINUOUS VOLUME DETECTION FOR A RESERVOIR IN A FLUID CIRCUIT OF A MEDICAL SYSTEM
    Publication number: 20080195022
    Abstract: Continuous volume detection for a reservoir in a fluid circuit of a medical system is described. Volume detection is based on a pressure measurement that is manipulated via application of fluid mechanics. Next-generation medical system controllers may use this data to control the volume contained in the reservoir.
    Type: Application
    Filed: April 10, 2008
    Publication date: August 14, 2008
    Inventors: Lori E. Lucke, Matthew J. Cunningham, Richard A. Nazarian
  • Continuous volume detection for a flexible venous reservoir in a cardiopulmonary bypass circuit
    Patent number: 7364563
    Abstract: A continuous volume detection system for a flexible venous reservoir in a cardiopulmonary bypass circuit is described. The volume detection system is based on a pressure measurement that is manipulated via application of fluid mechanics. Next-generation cardiopulmonary bypass system controllers may use this data to control the volume contained in the flexible venous reservoir.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: April 29, 2008
    Assignee: Minnetronix, Inc.
    Inventors: Lori E. Lucke, Matthew J. Cunningham, Richard A. Nazarian