Patents by Inventor Matthew J. Leith

Matthew J. Leith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Distribution of engineered-cysteine caps
    Patent number: 10828375
    Abstract: The present invention provides a method for removing cysteine caps from antibodies and re-capping the antibodies with cysteine molecules. The methods include, inter alia, culturing a host cell comprising a protein molecule having at least one capped engineered cysteine residue, and contacting the cell culture with cystine. Dissolved oxygen levels can be manipulated in the cell culture to further enhance the removal and re-capping process.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: November 10, 2020
    Assignee: Seattle Genetics, Inc.
    Inventors: Swapnil Bhargava, Cheng-Wei Aaron Chen, Matthew J. Leith
  • DISTRIBUTION OF ENGINEERED-CYSTEINE CAPS
    Publication number: 20190290777
    Abstract: The present invention provides a method for removing cysteine caps from antibodies and re-capping the antibodies with cysteine molecules. The methods include, inter alia, culturing a host cell comprising a protein molecule having at least one capped engineered cysteine residue, and contacting the cell culture with cystine. Dissolved oxygen levels can be manipulated in the cell culture to further enhance the removal and re-capping process.
    Type: Application
    Filed: November 6, 2017
    Publication date: September 26, 2019
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Swapnil Bhargava, Cheng-Wei Aaron Chen, Matthew J. Leith