Patents by Inventor Matthew J. Lesho

Matthew J. Lesho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7935499
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: May 3, 2011
    Assignee: Animas Corporation
    Inventors: Timothy C Dunn, Yalia Jayalakshmi, Ronald T Kurnik, Matthew J Lesho, Jonathan James Oliver, Russell O Potts, Janet A Tamada, Steven Richard Waterhouse, Charles W Wei
  • Patent number: 7711493
    Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: May 4, 2010
    Assignee: Animas Corporation
    Inventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
  • Patent number: 7699775
    Abstract: The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: April 20, 2010
    Assignee: Animas Technologies, LLC
    Inventors: Shashi P. Desai, Timothy C. Dunn, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Charles W. Wei
  • Publication number: 20100075863
    Abstract: An apparatus for multiplexing detection of one or more of a plurality of target molecules in a liquid sample includes a sample chamber adapted to receive a liquid sample containing one or more target molecules and a rotary array disposed in the sample chamber. The rotary array includes a plurality of spots, with each spot including at least one probe molecule selected to bind to a particular region of a target molecule. The apparatus also includes an optical detector capable of determining if a target molecule has bound to one of the probe molecules as the array rotates within the sample chamber.
    Type: Application
    Filed: September 25, 2008
    Publication date: March 25, 2010
    Applicant: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventors: Matthew J. LESHO, Christopher G. COONEY
  • Patent number: 7523004
    Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: April 21, 2009
    Assignee: Animas Technologies, LLC
    Inventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
  • Patent number: 7519478
    Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: April 14, 2009
    Assignee: Animas Technologies, LLC
    Inventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
  • Publication number: 20080270039
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Application
    Filed: June 30, 2008
    Publication date: October 30, 2008
    Applicant: Animas Technologies, LLC.
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Publication number: 20080262746
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Application
    Filed: June 30, 2008
    Publication date: October 23, 2008
    Applicant: Animas Technologies, LLC.
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Publication number: 20080262334
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Application
    Filed: June 30, 2008
    Publication date: October 23, 2008
    Applicant: Animas Technologies, LLC.
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Patent number: 7405055
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: July 29, 2008
    Assignee: Animas Technologies LLC
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Publication number: 20080124716
    Abstract: Rapid detection of biomolecules in samples involving biochemical amplification of the target biomolecule is achieved by collecting or separating aliquots of the amplification reaction mixture prior to completion of amplification and assaying these samples as they are collected.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 29, 2008
    Applicant: Northrop Grumman Systems Corporation
    Inventors: Christopher G. Cooney, Matthew J. Lesho
  • Patent number: 7295867
    Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: November 13, 2007
    Assignee: Animas Corporation
    Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
  • Patent number: 7024236
    Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: April 4, 2006
    Assignee: Animas Technologies LLC
    Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
  • Patent number: 7011630
    Abstract: The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: March 14, 2006
    Assignee: Animas Technologies, LLC
    Inventors: Shashi P. Desai, Timothy C. Dunn, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Charles W. Wei
  • Patent number: 6941163
    Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: September 6, 2005
    Assignee: Cygnus, Inc.
    Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
  • Publication number: 20040018486
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Application
    Filed: July 24, 2003
    Publication date: January 29, 2004
    Applicant: Cygnus, Inc.
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Publication number: 20030235817
    Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.
    Type: Application
    Filed: March 21, 2003
    Publication date: December 25, 2003
    Inventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
  • Publication number: 20030225319
    Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
    Type: Application
    Filed: June 12, 2003
    Publication date: December 4, 2003
    Applicant: Cygnus, Inc.
    Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
  • Patent number: 6653091
    Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: November 25, 2003
    Assignee: Cyngnus, Inc.
    Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
  • Patent number: 6633772
    Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: October 14, 2003
    Assignee: Cygnus, Inc.
    Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei