Patents by Inventor Matthew J. Lesho
Matthew J. Lesho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7935499Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: GrantFiled: June 30, 2008Date of Patent: May 3, 2011Assignee: Animas CorporationInventors: Timothy C Dunn, Yalia Jayalakshmi, Ronald T Kurnik, Matthew J Lesho, Jonathan James Oliver, Russell O Potts, Janet A Tamada, Steven Richard Waterhouse, Charles W Wei
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Patent number: 7711493Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.Type: GrantFiled: November 9, 2005Date of Patent: May 4, 2010Assignee: Animas CorporationInventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
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Patent number: 7699775Abstract: The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds.Type: GrantFiled: October 13, 2004Date of Patent: April 20, 2010Assignee: Animas Technologies, LLCInventors: Shashi P. Desai, Timothy C. Dunn, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Charles W. Wei
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Publication number: 20100075863Abstract: An apparatus for multiplexing detection of one or more of a plurality of target molecules in a liquid sample includes a sample chamber adapted to receive a liquid sample containing one or more target molecules and a rotary array disposed in the sample chamber. The rotary array includes a plurality of spots, with each spot including at least one probe molecule selected to bind to a particular region of a target molecule. The apparatus also includes an optical detector capable of determining if a target molecule has bound to one of the probe molecules as the array rotates within the sample chamber.Type: ApplicationFiled: September 25, 2008Publication date: March 25, 2010Applicant: NORTHROP GRUMMAN SYSTEMS CORPORATIONInventors: Matthew J. LESHO, Christopher G. COONEY
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Patent number: 7523004Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.Type: GrantFiled: November 9, 2005Date of Patent: April 21, 2009Assignee: Animas Technologies, LLCInventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
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Patent number: 7519478Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.Type: GrantFiled: November 9, 2005Date of Patent: April 14, 2009Assignee: Animas Technologies, LLCInventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
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Publication number: 20080270039Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: ApplicationFiled: June 30, 2008Publication date: October 30, 2008Applicant: Animas Technologies, LLC.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Publication number: 20080262334Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: ApplicationFiled: June 30, 2008Publication date: October 23, 2008Applicant: Animas Technologies, LLC.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Publication number: 20080262746Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: ApplicationFiled: June 30, 2008Publication date: October 23, 2008Applicant: Animas Technologies, LLC.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Patent number: 7405055Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: GrantFiled: July 24, 2003Date of Patent: July 29, 2008Assignee: Animas Technologies LLCInventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Publication number: 20080124716Abstract: Rapid detection of biomolecules in samples involving biochemical amplification of the target biomolecule is achieved by collecting or separating aliquots of the amplification reaction mixture prior to completion of amplification and assaying these samples as they are collected.Type: ApplicationFiled: November 29, 2006Publication date: May 29, 2008Applicant: Northrop Grumman Systems CorporationInventors: Christopher G. Cooney, Matthew J. Lesho
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Patent number: 7295867Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.Type: GrantFiled: February 12, 2003Date of Patent: November 13, 2007Assignee: Animas CorporationInventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Patent number: 7024236Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.Type: GrantFiled: April 8, 2004Date of Patent: April 4, 2006Assignee: Animas Technologies LLCInventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
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Patent number: 7011630Abstract: The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds.Type: GrantFiled: June 21, 2002Date of Patent: March 14, 2006Assignee: Animas Technologies, LLCInventors: Shashi P. Desai, Timothy C. Dunn, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Charles W. Wei
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Patent number: 6941163Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.Type: GrantFiled: June 12, 2003Date of Patent: September 6, 2005Assignee: Cygnus, Inc.Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
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Publication number: 20040018486Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: ApplicationFiled: July 24, 2003Publication date: January 29, 2004Applicant: Cygnus, Inc.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Publication number: 20030235817Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.Type: ApplicationFiled: March 21, 2003Publication date: December 25, 2003Inventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
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Publication number: 20030225319Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.Type: ApplicationFiled: June 12, 2003Publication date: December 4, 2003Applicant: Cygnus, Inc.Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
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Patent number: 6653091Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: GrantFiled: July 23, 2001Date of Patent: November 25, 2003Assignee: Cyngnus, Inc.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
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Patent number: 6633772Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.Type: GrantFiled: August 10, 2001Date of Patent: October 14, 2003Assignee: Cygnus, Inc.Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei