Abstract: A registration framework is presented that registers volumetric breast images captured before surgery with intraoperative surface images. The framework may be implemented using either image-based or model-based registration techniques. The method contains the steps of: identifying an air/tissue boundary from a volumetric image created at a first time; processing the volumetric image with an image filter to emphasize the air/tissue boundary; and registering a surface optically scanned image, with the filtered volumetric image, where the surface optically scanned image is created at a second time.