Abstract: The present disclosure relates to systems and method for deploying a fiber optic network. Distribution devices are used to index fibers within the system to ensure that live fibers are provided at output locations throughout the system. In an example, fibers can be indexed in multiple directions within the system. In an example, spare ports can be providing in a forward direction and reverse direction ports can also be provided.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: One or more devices are provided that are configured to detachably engage within a modular system. The one or more devices are expandable to provide a surface to perform work.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Elastomeric polyolefin-based ionomers and methods for making same. The ionomers can include a copolymer comprising: C2-C60 ?-olefin monomer units; optional C2-C60 ?-olefin comonomer units different than the monomer units; optional diene units; and about 0.1 wt % to about 20 wt % metal alkenyl units, based on the weight of the copolymer, wherein the metal alkenyl units have the formula —R(A?)—, wherein R is an alkyl group containing 2 to 10 carbon atoms, and A? is an anionic group. The copolymer can further include one or more metal cations derived from the group consisting of alkali metals, alkaline earth metals, group 3-12 metals, group 13-16 metals, and combination(s) thereof. The ionomer has a glass transition temperature of ?60° C. to 5° C., and a weight average (Mw) of 50 to 5,000 kg/mol.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: Implants, device, systems and methods for replacing an articulation surface in a joint, for example, shoulder prostheses with stemless humeral components or stemmed humeral components. Methods for using the shoulder prostheses with stemless humeral components or stemmed humeral components are also disclosed.

Abstract: An orthopedic implant apparatus, said apparatus comprising: a body, said body having a generally cylindrical shape and comprising a first material, a flat bottom surface, a concave upper surface disposed opposite said bottom surface, and a longitudinal axis disposed through the center of said body; a cylindrical bore, said bore disposed along said longitudinal axis through said top surface of said body; cylindrical plug, said plug comprising a second material and disposed within said bore of said body; and at least one stem, said at least one stem connected to said bottom surface of said body.

Abstract: An orthopedic trial implant having a plurality of bearing component augments of differing heights, where each augment releasably, slidably connected to the trial implant.

Abstract: An orthopedic implant apparatus, said apparatus comprising: a body, said body having a generally cylindrical shape and comprising a first material, a flat bottom surface, a concave upper surface disposed opposite said bottom surface, and a longitudinal axis disposed through the center of said body; a cylindrical bore, said bore disposed along said longitudinal axis through said top surface of said body; a cylindrical plug, said plug comprising a second material and disposed within said bore of said body; and at least one stem, said at least one stem connected to said bottom surface of said body.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

Abstract: A trial orthopedic implant having a plurality of bearing component augments of differing heights, where each augment releasably, slidably connected to the trial implant.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: A face engaging device such as a nozzle, facemask, etc., may include a housing including a fluid channel extending through the housing to an opening configured to be placed in fluid communication with the mouth of a user. The housing may include a first surface configured to be placed in contact with the skin of the user and a second surface exposed to the fluid channel. The face engaging device may also include a thermal actuator supported by the housing and including a first heat transfer surface position on the first surface, where the first heat transfer surface is configured to apply a thermal profile to the skin of the user when the opening is placed in fluid communication with the mouth of the user.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

Abstract: The present disclosure is directed offset adapters, trial implant systems, shoulder implant systems, and methods for total shoulder replacement, wherein the eccentricity of a humeral head relative to a humeral anchor and resected proximal portion of a humerus is selectable by a surgeon. A humeral head implant system includes a humeral head, an adapter, and humeral anchor. An offset adapter is operable to connect the humeral head to a humeral anchor. The offset adapter includes a first tapered cylindrical portion having a first axis, a second tapered cylindrical portion having a second axis, and the first axis being eccentrically disposed relative to the second axis of the adapter. A trial humeral head system includes a trial humeral head, a pin guide, and a trial adapter.

Abstract: A glenoid implant system for use in a reverse total shoulder replacement of a patient that includes a movable glenosphere, a baseplate, and a connector for movably connecting the glenosphere to the baseplate. The glenosphere and the baseplate are configured so that a central axis of the glenosphere is movable non-axially relative to a central axis of the baseplate. Further disclosed is a method having the steps of exposing and resecting a bone, securing a baseplate into the bone with the baseplate having a central axis, securing a glenosphere to the baseplate and non-axially moving the glenosphere relative to the central axis of the baseplate. Also disclosed is a method that includes the steps of rotating an arm in a medial direction, moving a glenosphere anteriorly relative to a baseplate attached to a glenoid, rotating the arm in a lateral direction, and moving the glenosphere posteriorly relative to the baseplate.

Abstract: An implant system includes a base plate having at least one thru-hole. A central screw is operable to extend from a lower surface of the base plate and anchor the base plate to a bone. At least one augmentation device is operable to extend through the at least one thru-hole. The augmentation device includes a post having a first end, a second end and a length sized to enable the augmentation device to traverse a defect in the bone when the base plate is anchored to the bone. A fastener portion is positioned at the first end of the post. The fastener portion is operable to fasten to the base plate. A footing portion is positioned at the second end of the post. The footing portion is operable to abut against a surface of the bone within the defect when the fastener portion is fastened to the base plate.