Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A sole structure for an article of footwear, the sole structure including a forefoot region and a heel region. The sole structure further includes a chassis plate, an outsole plate extending from the forefoot region to the heel region, the outsole plate including a recess disposed in a top surface, wherein the outsole plate is disposed below the chassis plate, and a cushioning element disposed within the recess.

Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.

Abstract: A system is provided. The system includes a substrate container having at least two purge modules. Each purge module of the at least two purge modules includes a flow control device. The flow control device of each purge module is configured to be actuated for egress of a purge fluid. A method of actuating flow control devices of purge modules of a substrate container is provided. The method includes starting a purge process of the substrate container; streaming a purge fluid into an interior of the substrate container, the substrate container having at least two purge modules, each purge module of the at least two purge modules including a flow control device, the flow control device of each purge module being configured to be actuated for egress of the purge fluid; and actuating the flow control device for egress of the purge fluid.

Abstract: A face engaging device such as a nozzle, facemask, etc., may include a housing including a fluid channel extending through the housing to an opening configured to be placed in fluid communication with the mouth of a user. The housing may include a first surface configured to be placed in contact with the skin of the user and a second surface exposed to the fluid channel. The face engaging device may also include a thermal actuator supported by the housing and including a first heat transfer surface position on the first surface, where the first heat transfer surface is configured to apply a thermal profile to the skin of the user when the opening is placed in fluid communication with the mouth of the user.

Abstract: A power tool is provided including a housing defining a cavity therein, where the housing includes a motor case and a handle portion extending along a longitudinal axis of the housing from the motor case; an electric motor having a drive shaft and mounted within the motor case; a partitioning wall extending radially and separating the motor case portion from the non-motor case portion of the housing; and a bearing pocket with an open end facing the motor case portion formed in the partitioning wall and a main body extending away from the electric motor for receiving a rotor bearing. The handle portion includes two elongate walls extending from the partitioning wall, a circuit board supported by the two elongate walls and including a motor drive circuit, and two covers secured to the two elongate walls to cover the circuit board.

Abstract: A work cell and method for automatically separating objects disposed in 3D clusters includes dispensing the objects onto a horizontal conveying surface to form a 2D array, reforming the 2D array into a 1D stream in which the objects move in single-file in a predefined moving direction, utilizing a vision-based or other stationary sensing system to identify a selected target object in the 1D stream as the target object passes through an image capture (sensing) region, calculating trajectory data defining the target object's time-based position in the 1D stream, and then utilizing the trajectory data to control a robot arm or other object removal mechanism such that only the selected object is forcibly removed (e.g., swiped or picked-up) from the horizontal conveying surface. A continuous-loop-type conveying mechanism includes two parallel conveyor-belt-type conveying structures and associated belt-switching structures. An AI-powered vision system identifies new object shapes during preliminary learning phases.

Abstract: A sleep assessment system includes a housing, processing circuitry, and a sensor assembly with a plurality of sensors configured to capture measurements that include indications of both brain and eye activity through the forehead of a subject. The processing circuitry is configured to receive sensor signals based on the measurements made by the plurality of sensors, process the sensor signals to generate sleep data, apply a sleep state convolutional neural network to the sleep data to determine a current sleep state of a subject, identify, based on the sleep data and the current sleep state, a sleep state-based data feature, and output a stimulus to the subject based on sleep state-based data feature. The housing is configured to be secured to the forehead of the subject, and the sensor assembly and processing circuitry are disposed on or within the housing.

Abstract: The present disclosure is directed offset adapters, trial implant systems, shoulder implant systems, and methods for total shoulder replacement, wherein the eccentricity of a humeral head relative to a humeral anchor and resected proximal portion of a humerus is selectable by a surgeon. A humeral head implant system includes a humeral head, an adapter, and humeral anchor. An offset adapter is operable to connect the humeral head to a humeral anchor. The offset adapter includes a first tapered cylindrical portion having a first axis, a second tapered cylindrical portion having a second axis, and the first axis being eccentrically disposed relative to the second axis of the adapter. A trial humeral head system includes a trial humeral head, a pin guide, and a trial adapter.

Abstract: A glenoid implant system for use in a reverse total shoulder replacement of a patient that includes a movable glenosphere, a baseplate, and a connector for movably connecting the glenosphere to the baseplate. The glenosphere and the baseplate are configured so that a central axis of the glenosphere is movable non-axially relative to a central axis of the baseplate. Further disclosed is a method having the steps of exposing and resecting a bone, securing a baseplate into the bone with the baseplate having a central axis, securing a glenosphere to the baseplate and non-axially moving the glenosphere relative to the central axis of the baseplate. Also disclosed is a method that includes the steps of rotating an arm in a medial direction, moving a glenosphere anteriorly relative to a baseplate attached to a glenoid, rotating the arm in a lateral direction, and moving the glenosphere posteriorly relative to the baseplate.

Abstract: An implant system includes a base plate having at least one thru-hole. A central screw is operable to extend from a lower surface of the base plate and anchor the base plate to a bone. At least one augmentation device is operable to extend through the at least one thru-hole. The augmentation device includes a post having a first end, a second end and a length sized to enable the augmentation device to traverse a defect in the bone when the base plate is anchored to the bone. A fastener portion is positioned at the first end of the post. The fastener portion is operable to fasten to the base plate. A footing portion is positioned at the second end of the post. The footing portion is operable to abut against a surface of the bone within the defect when the fastener portion is fastened to the base plate.

Abstract: A single-use handle is configured to attach to a working shaft that can support a sounder for measuring the medullary canal of a proximal radius, and a planarizer that is configured to planarize a proximal edge of the proximal radius after the proximal radius has been resected. The handle can further include a plurality of sizing cavities that are configured to receive the resected bone so as to determine the size of the resected bone. The handle can further include an ejector that is configured to decouple the planarizer from the working shaft.

Abstract: Embodiments related to a haptic actuator for transmitting heat and/or mechanical vibrations to an adjacent surface are disclosed. The haptic actuator may include a heating membrane, one or more supports, and a body. The one or more supports may extend between the body and the heating membrane to physically separate the heating membrane from the body.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: A single-use handle is configured to attach to a working shaft that can support a sounder for measuring the medullary canal of a proximal radius, and a planarizer that is configured to planarize a proximal edge of the proximal radius after the proximal radius has been resected. The handle can further include a plurality of sizing cavities that are configured to receive the resected bone so as to determine the size of the resected bone. The handle can further include an ejector that is configured to decouple the planarizer from the working shaft.

Abstract: A trial orthopedic implant having a plurality of bearing component augments of differing heights, where each augment releasably, slidably connected to the trial implant.

Abstract: A device for manipulating the temperature of a surface may include a heat transfer surface including active portions and a passive portion. The passive portion may include an inner passive portion disposed between each of the active portions and/or may include an outer passive portion that may surround each of the active portions. The active portions may form 40-90% of a total surface area of the heat transfer surface, where total surface area includes active portions and an inner passive portion. The passive portion(s) may have a thermal conductivity less than the active portion. A processor may be in electrical communication with thermoelectric modules defining or forming the active portions to generate a heat flux through the heat transfer surface. The heat flux through the active portions may be between 500 and 15,000 W/m2 during nominal operation of the device.

Abstract: A single-use handle is disclosed for releasably engaging an orthopedic device. The handle includes an elongate body that has a first portion that, in turn, defines a connection end adapted for connection to an upper end portion of a broach. The handle includes a second end portion adapted to be griped by a user. The handle further includes a cylindrical bore at the connection end. The bore is configured to receive a corresponding male portion of a surgical instrument. The handle further includes a button that is adapted to releasably connect the instrument in the bore. The handle further includes a plurality of sizing cavities that have a predetermined size and shape that corresponds to the size and shape of an orthopedic implant. The handle is of a biocompatible, disposable material.

Abstract: Systems and methods for manipulating the temperature of a surface are described. Described embodiments include thermal adjustment devices that may include a heatsink and that are operated in two or more modes of operation to apply a desired temperature to a user. In one operating mode the thermal adjustment device may apply a first temperature to an underlying surface while generating heat at a rate faster than the heatsink's heat dissipation rate. The thermal adjustment device may then apply a second temperature to reduce the rate of heat generation to be less than the heatsink's heat dissipation rate. These modes of operation may be applied cyclically to permit continuous operation of the thermal adjustment device. In some embodiments, the temperature profile applied when changing between the modes of operation may be selected such that the user experiences either a reduced, or substantially, neutral thermal sensation.