Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: Devices, systems and/or methods for fixating soft tissue to bone are provided. In one embodiment, a repair device for fixating soft tissue to bone with a bone anchor includes a soft tissue anchor and one or more flexible members. The soft tissue anchor includes a base with multiple legs extending from the base. The one or more flexible members are coupled to the base and configured to extend from the base to the bone anchor with a fixed length. With this arrangement, the fixed length of the one or more flexible members is configured to maintain a substantially fixed pre-determined distance between the soft tissue anchor and the bone anchor such that, as the bone anchor is seated into bone, the one or more flexible members pulls the soft tissue anchor down against the soft tissue to fixate the soft tissue to the bone.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Systems and methods for manipulating the temperature of a surface are described. Described embodiments include thermal adjustment devices that may include a heatsink and that are operated in two or more modes of operation to apply a desired temperature to a user. In one operating mode the thermal adjustment device may apply a first temperature to an underlying surface while generating heat at a rate faster than the heatsink's heat dissipation rate. The thermal adjustment device may then apply a second temperature to reduce the rate of heat generation to be less than the heatsink's heat dissipation rate. These modes of operation may be applied cyclically to permit continuous operation of the thermal adjustment device. In some embodiments, the temperature profile applied when changing between the modes of operation may be selected such that the user experiences either a reduced, or substantially, neutral thermal sensation.

Abstract: A data collection, display, and report generation platform has a first input interface configured to present a learning module comprising a series of questions and answers on a plurality of successive question/answer screens comprising a plurality of radio buttons, at least one of the radio buttons configured to accept both a first input action and a subsequent second input action, each providing a different visual indication. The first and second input action each indicate a different confidence level of a learner's answer. A display dashboard displays a plurality of data visualizations of metrics of misinformation and struggle of plurality of learners based on a plurality of answers collected through the first input interface, and comprises one or more bar graph displays, one or more heat map displays, and one or more sorting tools configured to alter the one or more bar graph displays or one or more heat map displays.

Abstract: A system for redundantly detecting a gas is provided. The system includes first and second series-connected gas sensors and a signaling module. If both gas sensors are functioning normally, the signaling module provides an alert when both gas sensors detect a predetermined gas concentration. If however any one of the gas sensors is experiencing a fault condition, the faulty gas sensor's alarm is shunted by operation of a fault relay, and the signaling module provides an alert when the non-faulty gas sensor detects a predetermined gas concentration. If both gas sensors are experiencing a fault condition, both gas sensors' alarms are shunted by fault relays, and an audible and/or visual alert is generated by the signaling module. Embodiments of the present invention are well suited for industrial facilities, manufacturing facilities, research and development laboratories, and other locations where unsafe gas concentrations may become present.

Abstract: A power tool comprising: a housing including a motor case and a handle portion extending along a longitudinal axis of the housing from the motor case; an electric motor having a drive shaft and mounted within the motor case; a partitioning wall extending radially between the motor case and the handle portion and forming a bearing pocket therein; a rear bearing mounted on the drive shaft and received into the bearing pocket to support the drive shaft relative to the housing; two elongate walls extending rearwardly from the partitioning wall along two sides of the handle portion; a power control module supported by the two elongate walls within the handle portion, the power control module including a circuit board having a motor drive circuit configured to drive the electric motor; and at least one cover secured to the two elongate walls to cover the circuit board.

Abstract: Described are support devices that are useful with substrate containers used to hold or transport substrates in a clean environment, as well as associated systems and methods of using the support devices and substrate containers.

Abstract: A propulsion system for an aircraft includes an engine having a central axis. A cowl surrounds the engine and includes a cowl lip. A compression ramp is spaced away from the cowl lip. An inlet is formed by the cowl lip and the compression ramp. The compression ramp is non-planar. The compression ramp is movable relative to the cowl lip to vary compression of an inlet airflow through the inlet.

Abstract: A steering shaft assembly includes a shaft having an end region to be coupled to another component with a mechanical fastener, the shaft comprising a protrusion extending radially outwardly from the shaft within the end region of the shaft. The steering shaft assembly also includes a ring flag coupleable to the end region of the shaft, the ring flag comprising a recess positioned to receive the protrusion of the shaft at a desired relative axial position of the ring flag and the shaft to rotationally align the ring flag and the shaft at a desired rotational position.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Systems and methods are presented that automatically construct a directed acyclic graph (DAG) workflow used to control and manage algorithms on multiple, disparate, cloud-based development and deployment platforms. DAG workflows are comprised of a set of simplified, fixed time-affecting linear pathways (STALPs). Algorithms are constructed using no-code/low-code methods that are then automatically decomposed into a set of markup or scripting language time-affecting linear pathways (M-S TALPs). Prediction polynomials that approximate advanced time and space complexity functions are created using M-S TALPs and are used for M-S TALP identification, optimization, efficiency, and performance enhancement on selected computing platforms.

Abstract: A single-use handle is configured to attach to a working shaft that can support a sounder for measuring the medullary canal of a proximal radius, and a planarizer that is configured to planarize a proximal edge of the proximal radius after the proximal radius has been resected. The handle can further include a plurality of sizing cavities that are configured to receive the resected bone so as to determine the size of the resected bone. The handle can further include an ejector that is configured to decouple the planarizer from the working shaft.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Implants, device, systems and methods for replacing an articulation surface in a joint, for example, shoulder prostheses with stemless humeral components or stemmed humeral components. Methods for using the shoulder prostheses with stemless humeral components or stemmed humeral components are also disclosed.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

Abstract: Implants, device, systems and methods for replacing an articulation surface in a joint, for example, shoulder prostheses with stemless humeral components or stemmed humeral components. Methods for using the shoulder prostheses with stemless humeral components or stemmed humeral components are also disclosed.

Abstract: An orthopedic implant apparatus, said apparatus comprising: a body, said body having a generally cylindrical shape and comprising a first material, a flat bottom surface, a concave upper surface disposed opposite said bottom surface, and a longitudinal axis disposed through the center of said body; a cylindrical bore, said bore disposed along said longitudinal axis through said top surface of said body; cylindrical plug, said plug comprising a second material and disposed within said bore of said body; and at least one stem, said at least one stem connected to said bottom surface of said body.