Abstract: A method of prioritizing cleaning of rooms of an environment for a mobile cleaning robot can include generating a cleanliness score for each room of the environment using a controller. Each of the cleanliness scores can be indicative of an amount of debris expected in each respective room by the mobile cleaning robot. The method can also include generating a room cleaning priority based at least partially on the cleanliness score of each of the rooms. The method can also include scheduling operations of the mobile cleaning robot for a planned mission based on the room cleaning priority of each of the rooms of the environment.

Abstract: Systems and methods for manipulating the temperature of a surface are described. Described embodiments include thermal adjustment devices that may include a heatsink and that are operated in two or more modes of operation to apply a desired temperature to a user. In one operating mode the thermal adjustment device may apply a first temperature to an underlying surface while generating heat at a rate faster than the heatsink's heat dissipation rate. The thermal adjustment device may then apply a second temperature to reduce the rate of heat generation to be less than the heatsink's heat dissipation rate. These modes of operation may be applied cyclically to permit continuous operation of the thermal adjustment device. In some embodiments, the temperature profile applied when changing between the modes of operation may be selected such that the user experiences either a reduced, or substantially, neutral thermal sensation.

Abstract: A method and apparatus for generating light includes a chamber having a high voltage region, a low voltage region, and a plasma generation region that defines a plasma confinement region. A magnetic core is positioned around the chamber and is configured to generate a plasma in the plasma confinement region. A switched power supply includes a DC power supply and a switched resonant charging circuit that together generate a plurality of voltage pulses at the output causing a plurality of current pulses to be applied to the power delivery section around the magnetic core so that at least one plasma loop is established around the magnetic core that confines plasma in the plasma confinement region, thereby forming a magnetically confined Z-pinch plasma. Light generated by the Z-pinch plasma propagates out of a port in the light source.

Abstract: The present disclosure relates to systems and method for deploying a fiber optic network. Distribution devices are used to index fibers within the system to ensure that live fibers are provided at output locations throughout the system. In an example, fibers can be indexed in multiple directions within the system. In an example, spare ports can be providing in a forward direction and reverse direction ports can also be provided.

Abstract: An elbow arthroplasty system having a ball and a socket. The ball is configured for coupling to at least one member of one of the following groups: (i) a humerus, and (ii) a radius, an ulna, or both of the radius and the ulna. The socket is configured for coupling to at least one member of the other of the following groups: (i) the humerus, and (ii) the radius, the ulna, or both of the radius and the ulna. The socket defines a cavity that is configured to receive at least a portion of the ball. The ball may be a spheroid, an ellipsoid, a sphere, or a portion of one of the foregoing with a convex surface. The socket may be configured with a concave surface that is spheroidal, ellipsoidal, or spherical and designed to mate with the ball. An elbow arthroplasty method using a ball and a socket.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: A glenoid implant of a shoulder prosthesis includes a baseplate having a shaft coupled to, and extending from a bottom surface, of its plate. The plate includes a peripheral ring extending downwardly away from, and circumferentially around, its bottom surface. The exterior surfaces of the peripheral ring have threads formed therein. A method of installing a glenoid implant during an orthopaedic surgical procedure is also disclosed.

Abstract: A glenoid implant includes a baseplate, a pair of bone screws, and an augmentation member. The baseplate includes a plurality of screw holes with the pair of bone screws being positioned in two of the screw holes and the augmentation member being positioned in a third screw hole. The augmentation member includes a non-threaded post configured to abut the bottom of a bone defect. A method of installing a glenoid implant during an orthopaedic surgical procedure is also disclosed.

Abstract: The system and methods of the present invention use sensor hardware, software, and connectivity, both between sensors and with occupants of the commercial, private, or public building, for building service utilization and capacity optimization and for personal and mass safety. One or more clusters of different sensor types are deployed in an indoor setting and can be used to nurture, protect, and assist occupants of that indoor setting. The human-centric concepts herein are also shown to be applicable to both medical triage and transportation settings.

Abstract: Systems and methods for manipulating the temperature of a surface are described. Described embodiments include thermal adjustment devices that may include a heatsink and that are operated in two or more modes of operation to apply a desired temperature to a user. In one operating mode the thermal adjustment device may apply a first temperature to an underlying surface while generating heat at a rate faster than the heatsink's heat dissipation rate. The thermal adjustment device may then apply a second temperature to reduce the rate of heat generation to be less than the heatsink's heat dissipation rate. These modes of operation may be applied cyclically to permit continuous operation of the thermal adjustment device. In some embodiments, the temperature profile applied when changing between the modes of operation may be selected such that the user experiences either a reduced, or substantially, neutral thermal sensation.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Systems and methods are presented that automatically construct a directed acyclic graph (DAG) workflow used to control and manage algorithms on multiple, disparate, cloud-based development and deployment platforms. DAG workflows are comprised of a set of simplified, fixed time-affecting linear pathways (STALPs). Algorithms are constructed using no-code/low-code methods that are then automatically decomposed into a set of markup or scripting language time-affecting linear pathways (M-S TALPs). Prediction polynomials that approximate advanced time and space complexity functions are created using M-S TALPs and are used for M-S TALP identification, optimization, efficiency, and performance enhancement on selected computing platforms.

Abstract: A single-use handle is configured to attach to a working shaft that can support a sounder for measuring the medullary canal of a proximal radius, and a planarizer that is configured to planarize a proximal edge of the proximal radius after the proximal radius has been resected. The handle can further include a plurality of sizing cavities that are configured to receive the resected bone so as to determine the size of the resected bone. The handle can further include an ejector that is configured to decouple the planarizer from the working shaft.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

Abstract: Implants, device, systems and methods for replacing an articulation surface in a joint, for example, shoulder prostheses with stemless humeral components or stemmed humeral components. Methods for using the shoulder prostheses with stemless humeral components or stemmed humeral components are also disclosed.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.