Abstract: The present disclosure provides extracorporeal membrane oxygenation (ECMO) apparatuses treated to comprise lubricating liquid surfaces, hydrophobic or omniphobic surfaces, and/or fluid and solid repellant slippery surfaces that do not stimulate clotting and thrombus formation to the same degree as do the untreated surfaces. The apparatuses permit ECMO procedures to be conducted using less anticoagulant and/or antiplatelet medications than is possible with untreated apparatuses. Also described are methods of using the treated apparatuses to accomplish ECMO procedures on subjects (e.g., human patients) and upon perfused organs.