Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amount of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: A method and system are presented for selectively entering lottery entries into a state lottery drawing via an internet web site, the method includes the initial step of entering the home page of the web site. There is querying of users for their sign-in identification to establish whether they are pre-registered user members or non-members. Pre-registered user members are presented with a choice of member functions and content as to account information, and selection of a game to be played. Non-members are presented with a choice of different functions and content including the ability to establish an account. Both members and non-members may access functions and content including information relating to gambling addiction, and descriptions of the games that may be played.

Abstract: A method and system are presented for selectively entering lottery entries into a state lottery drawing via an internet web site, the method includes the initial step of entering the home page of the web site. There is querying of users for their sign-in identification to establish whether they are pre-registered user members or non-members. Pre-registered user members are presented with a choice of member functions and content as to account information, and selection of a game to be played. Non-members are presented with a choice of different functions and content including the ability to establish an account. Both members and non-members may access functions and content including information relating to gambling addiction, and descriptions of the games that may be played.