Abstract: Methods of purification for the large scale synthesis of CB[7]-PEG may include at least one of diafiltration or tangential flow filtration, column chromatography, affinity “pull-down” techniques, or selective precipitation methods. In one embodiment, the method includes providing a reaction mixture containing synthesized CB[7]-PEG, providing a membrane selected to be below the nominal molecular weight of CB[7]-PEG, and removing small molecular weight contaminant species from the reaction mixture using the membrane. In embodiments, regardless of which purification method is used, a copper catalyst component of the “click” chemistry reaction mixture may be removed using a commercially available metal-chelating resin.

Abstract: Described herein are glucose-stabilized materials for glucose-responsive delivery of glucagon or a glucagon analogue to combat hypoglycemia and related disorders. Exemplary glucose-stabilized materials of the present invention include hydrogels comprising glucagon or a glucagon analogue and a peptide. Enzymatic control of molecular self-assembly and hydrogelation described herein enables encapsulation and glucose-responsive delivery of a therapeutic to address low glucose.

Abstract: Described herein are compositions and methods for a novel drug delivery platform using affinity homing. Also disclosed herein are a drug delivery system, methods for using the novel drug delivery platform and a kit.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: A highly permeable sorbent platform based on polysulfone and polystyrene-b-poly(acrylic acid) composite membranes. The membranes possess a fully interconnected network of poly(acrylic acid)-lined pores, which enables the surface chemistry to be tailored through sequential attachment of polyethyleneimine moieties and metal-binding terpyridine ligands. The polyethyleneimine moieties increase the saturation capacity, while the addition of terpyridine enables high-affinity binding to a diversity of transition metal ions. This membrane platform removes such metal contaminants from solution. The metal capture performance of the functionalized membranes persists even in high concentrations of competitive ions. Also, fluorescence quenching of the terpyridine moiety upon metal ion complexation offers an in-situ probe to monitor the extent of sorbent saturation.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: Described herein are compositions and methods for a novel drug delivery platform using affinity homing. Also disclosed herein are a drug delivery system, methods for using the novel drug delivery platform and a kit.

Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Abstract: Aspects of the invention include intercepting a rendering of a picture at a website, the picture uploaded to a server of the website by a content provider. Access criteria associated with a user at a user device is determined. The access criteria includes a relationship between the user and one or both of the content provider and content of the picture. A resolution of a modified rendering of the picture is determined based at least in part on the access criteria. The modified rendering of the picture is generated based at least in part on the resolution. The modified rendering of the picture is displayed at the user device.

Abstract: Aspects of the invention include intercepting a rendering of a picture at a website, the picture uploaded to a server of the website by a content provider. Access criteria associated with a user at a user device is determined. The access criteria includes a relationship between the user and one or both of the content provider and content of the picture. A resolution of a modified rendering of the picture is determined based at least in part on the access criteria. The modified rendering of the picture is generated based at least in part on the resolution. The modified rendering of the picture is displayed at the user device.

Abstract: Aspects of the invention include intercepting a rendering of a picture at a website, the picture uploaded to a server of the website by a content provider. Access criteria associated with a user at a user device is determined. The access criteria includes a relationship between the user and one or both of the content provider and content of the picture. A resolution of a modified rendering of the picture is determined based at least in part on the access criteria. The modified rendering of the picture is generated based at least in part on the resolution. The modified rendering of the picture is displayed at the user device.

Abstract: Aspects of the invention include intercepting a rendering of a picture at a website, the picture uploaded to a server of the website by a content provider. Access criteria associated with a user at a user device is determined. The access criteria includes a relationship between the user and one or both of the content provider and content of the picture. A resolution of a modified rendering of the picture is determined based at least in part on the access criteria. The modified rendering of the picture is generated based at least in part on the resolution. The modified rendering of the picture is displayed at the user device.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

Abstract: Disclosed herein is a completely synthetic cell-free therapy based on peptide amphiphile nanostructures designed to mimic the activity of vascular endothelial growth factor (VEGF), one of the most potent angiogenic signaling proteins. The VEGF-mimetic filaments disclosed herein were found to induce phosphorylation of VEGF receptors and induce pro-angiogenic behavior in endothelial cells, indicated by an enhancement in proliferation, survival and migration in vitro.