Patents by Inventor Matthew J. Wyvratt, Jr.

Matthew J. Wyvratt, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic lactams as antihypertensives
    Patent number: 4661479
    Abstract: This invention relates to bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: April 28, 1987
    Assignee: Merck and Co., Inc.
    Inventors: Matthew J. Wyvratt, Jr., Eugene D. Thorsett, Edward W. Tristram, Arthur A. Patchett, Elbert E. Harris
  • O-sulfate derivatives of avermectins and milbemycins having improved water solubility
    Patent number: 4622313
    Abstract: There are disclosed novel O-sulfate derivatives of avermectin and milbemycin. The avermectin and milbemycin O-sulfate derivatives have improved water solubility compared to the parent avermectin and milbemycin compounds and have utility as anti-parasitic agents and as potent insecticides against agricultural pests.
    Type: Grant
    Filed: August 1, 1985
    Date of Patent: November 11, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Matthew J. Wyvratt, Jr.
  • Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
    Patent number: 4617301
    Abstract: Sulfoxide and sulfone derivatives of bicyclic lactams are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: October 14, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Matthew J. Wyvratt, Jr.
  • Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use
    Patent number: 4581345
    Abstract: There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presence of an activated form of zinc. The avermectin 8,9-cyclopropyl compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: April 8, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Matthew J. Wyvratt, Jr.
  • Bicyclic lactams
    Patent number: 4415496
    Abstract: The invention relates to bicyclic lactams and related compounds which are useful as antihypertensives.
    Type: Grant
    Filed: February 19, 1982
    Date of Patent: November 15, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Edward W. Tristram, Eugene D. Thorsett, Matthew J. Wyvratt, Jr.