Patents by Inventor Matthew James BOTTOMLEY

Matthew James BOTTOMLEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240383949
    Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
    Type: Application
    Filed: February 7, 2024
    Publication date: November 21, 2024
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Enrico MALITO, Matthew James BOTTOMLEY, Andrea CARFI, Sumana CHANDRAMOULI, Kate LUISI
  • Patent number: 11932669
    Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: March 19, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Enrico Malito, Matthew James Bottomley, Andrea Carfi, Sumana Chandramouli, Kate Luisi
  • Publication number: 20230303637
    Abstract: Polypeptides capable of self-assembling into a nanoparticle, and nanoparticles made up of such polypeptides.
    Type: Application
    Filed: June 11, 2021
    Publication date: September 28, 2023
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew James BOTTOMLEY, Newton Muchugu WAHOME
  • Publication number: 20230250142
    Abstract: Pairs of peptides capable of forming spontaneous covalent bonds, and their uses, such as in forming fusion proteins.
    Type: Application
    Filed: June 11, 2021
    Publication date: August 10, 2023
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew James BOTTOMLEY, Roberta COZZI, Newton Muchugu WAHOME
  • Publication number: 20210277067
    Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
    Type: Application
    Filed: April 6, 2021
    Publication date: September 9, 2021
    Inventors: Enrico MALITO, Matthew James BOTTOMLEY, Andrea CARFI, Sumana CHANDRAMOULI, Kate LUISI
  • Publication number: 20170350893
    Abstract: The invention relates to a method of determining an increased risk of cancer in an immunosuppressed patient, the method comprising: (a) determining the percentage of CD8+CD57+ T-cells in a population of CD8+ T-cells in a sample from the patient; wherein a percentage of 40% or greater of CD8+CD57+ T-cells is indicative of an increased risk of cancer; and/or (b) determining the percentage of CD4+CD57+ T-cells in a population of CD4+ T-cells in a sample from the patient; wherein a percentage of 10% or greater of CD4+CD57+ T-cells is indicative of an increased risk of cancer.
    Type: Application
    Filed: October 23, 2015
    Publication date: December 7, 2017
    Inventors: Paul Neil HARDEN, Kathyrn Jayne WOOD, Matthew James BOTTOMLEY