Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A beverage dispenser for dispensing a beverage into a vessel, the beverage dispenser including a vessel-receiving region in which the vessel is locatable for receiving beverage; and a sensor arrangement for providing signals based on which a distance between one or more wall portions of the vessel, when located in the vessel-receiving region, and the sensor arrangement can be determined, wherein a volume of beverage to be dispensed into the vessel can be determined based on the determined distance between one or more wall portions of the vessel and the sensor arrangement.

Abstract: The present invention relates generally to a beverage dispensing device for dispensing a beverage such as beer, and in particular, to a beverage dispensing device configured to be able to dispense a beverage and infuse the beverage with a flavor as part of the dispensing process.