Patents by Inventor Matthew John Siegel

Matthew John Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10434150
    Abstract: Oral administration of ALV003 can protect celiac disease patients and patients otherwise suffering from gluten-intolerance from the harmful effects of ingesting food containing gluten.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: October 8, 2019
    Assignee: Immunogenics LLC
    Inventors: Bret Berner, Matthew John Siegel
  • Publication number: 20150352195
    Abstract: Oral administration of ALV003 can protect celiac disease patients and patients otherwise suffering from gluten-intolerance from the harmful effects of ingesting food containing gluten.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 10, 2015
    Inventors: Bret Berner, Matthew John Siegel
  • Publication number: 20150197738
    Abstract: Gluten-degrading proteases can be used to degrade gluten and for making gluten-containing food safer for patients suffering from gluten intolerance. The present invention provides recombinant expression vectors encoding the proteases of the invention and methods for using such vectors to produce the encoded proteases. In another aspect, the present invention provides pharmaceutical formulations and unit dose forms suitable for oral administration.
    Type: Application
    Filed: July 9, 2013
    Publication date: July 16, 2015
    Inventor: Matthew John Siegel
  • Patent number: 8980254
    Abstract: Pharmaceutical formulations of orally administered proteins can be stabilized from oxidative degradation and inactivation in the stomach and GI tract by the addition of an antioxidant.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: March 17, 2015
    Assignee: Alvine Pharmaceuticals, Inc.
    Inventors: Matthew John Siegel, Bret Berner
  • Patent number: 8871718
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 28, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Kihang Choi
  • Publication number: 20140205587
    Abstract: Gluten-degrading proteases can be used to degrade gluten and for making gluten-containing food safer for patients suffering from gluten intolerance.
    Type: Application
    Filed: June 13, 2012
    Publication date: July 24, 2014
    Applicant: ALVINE PHARMACEUTICALS, INC.
    Inventor: Matthew John Siegel
  • Patent number: 8778338
    Abstract: A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be administered as lyophilized powders or simple capsules/tablets. A ratio of the two enzymes is used to maximize their synergy.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: July 15, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jonathan David Gass, Chaitan Khosla, Michael Bethune, Matthew John Siegel
  • Patent number: 8470782
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 25, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Publication number: 20110171201
    Abstract: Pharmaceutical formulations of orally administered proteins can be stabilized from oxidative degradation and inactivation in the stomach and GI tract by the addition of an antioxidant.
    Type: Application
    Filed: August 21, 2009
    Publication date: July 14, 2011
    Inventors: Matthew John Siegel, Bret Berner
  • Publication number: 20100092451
    Abstract: A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be administered as lyophilized powders or simple capsules/tablets. A ratio of the two enzymes is used to maximize their synergy.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 15, 2010
    Inventors: Jonathan David Gass, Chaitan Khosla, Michael Bethune, Matthew John Siegel
  • Publication number: 20090312272
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: December 17, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Patent number: 7579313
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 25, 2009
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Washington University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Publication number: 20090156490
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Application
    Filed: September 25, 2008
    Publication date: June 18, 2009
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel
  • Publication number: 20090042806
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 12, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Patent number: 7462688
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: December 9, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel
  • Publication number: 20080299108
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
    Type: Application
    Filed: August 3, 2006
    Publication date: December 4, 2008
    Inventors: Chaitan Khosla, Jiang Xia, Matthew John Siegel