Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Disclosed herein are improved cross-linked resilin compositions and methods of making these improved compositions. These include new methods of cross-linking resilin compositions, use of polar nonaqueous solvents for adjusting material properties of cross-linked resilin solid compositions, and resilin foam compositions and methods of making the same.

Abstract: Systems and methods are provided for performing operations including: receiving, by a messaging application, input that selects an option to generate a message using an avatar with a caption; presenting, by the messaging application, the avatar and a caption entry region proximate to the avatar; populating, by the messaging application, the caption entry region with a text string comprising one or more words; determining, by the messaging application, context based on the one or more words in the text string; and modifying, by the messaging application, an expression of the avatar based on the determined context.

Abstract: The present invention generally relates to a modular high power bi-directional half bridge buck/boost converter assembly and, in particular, to a system for converting power from one form of current (either AC or DC) to a differing level of voltage, either lower (buck) or higher (boost), to output a wave signal based on pulse wave modulation (PWM) switching control by means of an external digital controller and methods of operation. In particular, an inverter-converter system includes at least one half bridge module including a plurality of circuit components, at least one inductor which is connected to the at least one half bridge module and a power supply, and a controller which is configured to receive and send instructions to the at least one half bridge module for converting an input voltage to an output voltage and dynamically tune switching frequencies based on a load of the inverter-converter system.

Abstract: An example fluid collection assembly includes a fluid impermeable barrier defining at least one opening, a chamber, and at least one fluid outlet. The fluid collection assembly also includes at least one porous material disposed in the chamber. The fluid collection assembly further includes at least one inflation device. The inflation device includes bladder having one or more walls defining an interior region. The inflation device also includes at least one valve configured to selectively permit fluid flow into and out of the interior region to switch the bladder between a first state and a second state. The inflation device may at least one of controllably change the length of the fluid collection assembly or controllably change a width of at least a portion of the fluid collection assembly to more comfortably fit the fluid collection assembly within the labia folds of an individual using the fluid collection assembly.

Abstract: Metal films, such as molybdenum films are deposited on a semiconductor substrate having one or more recessed features in a deposition process modulated by addition of a halogen-containing compound (e.g., an alkyl halide). In some implementations, a pre-treatment of a substrate with a halogen-containing compound is performed prior to contacting the substrate with a metal-containing precursor and a reducing agent. In some embodiments, the pre-treatment is performed such that the halogen-containing compound modifies the surface of the substrate to a greater degree in a field region of the substrate and near the opening of the recessed feature, as compared to the bottom portion of the recessed feature, where the modification of the substrate inhibits deposition of the metal. As a result, deposition of metals with improved step coverage can be achieved. In some implementations, modulation of deposition by halogen-containing compounds is used to achieve bottom-up metal growth in recessed features.

Abstract: Embodiments described herein relate generally to systems and methods for continuously and/or semi-continuously manufacturing electrochemical cells with semi-solid electrodes. In some embodiments, a method can include mixing an active material, a conductive material, and an electrolyte to form a semi-solid electrode material. The method further includes drawing a vacuum on the semi-solid electrode material, compressing the semi-solid electrode material to form an electrode brick, and dispensing a portion of the electrode brick onto a current collector via a dispensation device to form an electrode. In some embodiments, the current collector is disposed on a pouch material. In some embodiments, the dispensation device includes a top blade for top edge control and two side plates for side edge control. In some embodiments, the method can further include conveying the electrode through the top blade and the two side plates to shape the electrode.

Abstract: In some aspects, a computing system can generate and optimize a machine learning model to estimate an unobservable capacity of a target system or entity. The computing system can access training vectors which include training predictor variables, training performance indicators, and task quantities. A training performance indicator indicating performance outcome corresponding to the predictor variables and a task quantity associated with a task assigned to the target entity that leads to the training performance indicator. The machine learning model can be trained by performing adjustments of parameters of the machine learning model to minimize a loss function defined based on the training vectors. The trained machine learning model can be used to estimate the capacity of the target system or entity for handling tasks and be used in assigning tasks to the target entity according to the determined capacity.

Abstract: Method of generating animation overlays starts with a processor causing a communication interface for a communication session to be displayed at client devices. The processor receives from a first client device an animation sending request and causes an animation sending interface to be displayed in the communication interface of the first client device. The animation sending interface comprises animation overlay icons. Each of the animation overlay icons comprise a first avatar associated with the first user. The processor receives from the first client device a selection of a first animation overlay icon and causes the first animation overlay corresponding to the first animation overlay icon to be displayed as an overlay on the communication interface of each of the plurality of client devices. The first animation overlay is an animation that includes the first avatar. Other embodiments are disclosed.

Abstract: Toilet tissue having a dynamic surface comprising a surface material that overlays a textured web material such that the toilet tissue exhibits one or more novel properties and method for making same are provided.

Abstract: A method of fabricating a transmission target for an X-ray system is provided. The method includes forming a substrate and etching at least one via in the substrate. The method includes depositing a layer of seed metal on the surface of the substrate. The method includes filling the vias with a target metal to form target metal blocks.

Abstract: A system and method for determining event discrepancies between disparate systems is described. The system can receive sets of events from multiple systems. The system can normalize the sets of events to convert them into normalized events. From a normalized set of events, the system can concurrently generate a plurality of event arrays. The system can apply one or more rules to the event arrays to generate at least one event array parameter.

Abstract: The present invention generally relates to a modular high power bi-directional half bridge buck/boost converter assembly and, in particular, to a system for converting power from one form of current (either AC or DC) to a differing level of voltage, either lower (buck) or higher (boost), to output a wave signal based on pulse wave modulation (PWM) switching control by means of an external digital controller and methods of operation. In particular, an inverter-converter system includes at least one half bridge module including a plurality of circuit components, at least one inductor which is connected to the at least one half bridge module and a power supply, and a controller which is configured to receive and send instructions to the at least one half bridge module for converting an input voltage to an output voltage and dynamically tune switching frequencies based on a load of the inverter-converter system.

Abstract: Hierarchical virtualization creates a child guest partition that shares a hypervisor with a parent guest partition. A hypervisor receives a request, from a first guest partition that operates at the hypervisor, to create a second guest partition as a child of the first guest partition. The hypervisor identifies a configuration specification for the second guest partition, which includes (1) an identification of a memory portion, which is allocated to the first guest partition, that is to be mapped into the second guest partition; and (2) a configuration of a virtual processor that is to be utilized by the second guest partition. The hypervisor creates the second guest partition based on the configuration specification.

Abstract: Methods for forming a blade for a gas turbine engine include altering the crystallographic texture of the blade in a discrete region relative to the surrounding locations of the blade to minimize flutter and/or mistune the blade by changing the natural frequency response of at least one mode of the blade.

Abstract: Systems and methods for cultivating or accumulating climate-focused marine target products are described herein. The target product may be microalgae, macroalgae, plankton, marine bacteria or archaea, filter feeders (such as oysters or clams), or crustaceans either for the purpose of bioremediation, eventual cultivation or for sequestering carbon dioxide; or the target product may be direct chemical or biological accumulation of carbon or carbon containing organisms. The system is primarily a floating apparatus designed to hold the target product in a region of the water column and in a spatial region of the water where it will best accumulate target product mass. In some embodiments the system is designed to achieve eventual passive sinking (transformation from a floating to sinking apparatus) into the deep ocean. In some embodiments, the system is equipped with purpose-chosen sensors to instrument and quantify the various biological and mechanical processes occurring onboard.

Abstract: The present invention generally relates to a modular high power bi-directional half bridge buck/boost converter assembly and, in particular, to a system for converting power from one form of current (either AC or DC) to a differing level of voltage, either lower (buck) or higher (boost), to output a wave signal based on pulse wave modulation (PWM) switching control by means of an external digital controller and methods of operation. In particular, an inverter-converter system includes at least one half bridge module including a plurality of circuit components, at least one inductor which is connected to the at least one half bridge module and a power supply, and a controller which is configured to receive and send instructions to the at least one half bridge module for converting an input voltage to an output voltage and dynamically tune switching frequencies based on a load of the inverter-converter system.

Abstract: The present invention generally relates to a modular high power bi-directional half bridge buck/boost converter assembly and, in particular, to a system for converting power from one form of current (either AC or DC) to a differing level of voltage, either lower (buck) or higher (boost), to output a wave signal based on pulse wave modulation (PWM) switching control by means of an external digital controller and methods of operation. In particular, an inverter-converter system includes at least one half bridge module including a plurality of circuit components, at least one inductor which is connected to the at least one half bridge module and a power supply, and a controller which is configured to receive and send instructions to the at least one half bridge module for converting an input voltage to an output voltage and dynamically tune switching frequencies based on a load of the inverter-converter system.

Abstract: An aquaculture system includes a pen configured to be disposed in a body of water and configured to at least temporarily store aquatic animals during development. A control system is configured to receive electric power from a power source and is configured to provide electric power to a pumping mechanism coupled to the pen such that the pumping mechanism provides a flow of water through the pen. A set of buoyancy tanks are coupled to the pen. A portion of the control system is in fluid communication with the set of buoyancy tanks and is configured to adjust a volume of fluid in at least one buoyancy tank to move the pen from a first position in which the pen is partially submerged in the body of water to a second position in which the pen is fully submerged in the body of water.