Patents by Inventor Matthew Joseph Davis

Matthew Joseph Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240136000
    Abstract: A digital thermometer includes a first oscillator to generate a first clock signal, wherein a period of the first clock signal remains constant in view of changes in a temperature of the apparatus and a first counter coupled to the first oscillator, the first counter to count a fixed number of cycles of the first clock signal associated with a measurement period. The digital thermometer further includes a second oscillator to generate a second clock signal, wherein a period of the second clock signal varies with changes in the temperature and a second counter coupled to the second oscillator, the second counter to generate an output representing a count of a number of cycles of the second clock signal that occur during the measurement period. In addition, the digital thermometer includes calibration circuitry coupled to the second counter, the calibration circuitry to calibrate the output of the second counter to generate a value representing the temperature of the apparatus.
    Type: Application
    Filed: October 17, 2023
    Publication date: April 25, 2024
    Inventors: Chiara Cerafogli, Kenneth William Marr, Marco Domenico Tiburzi, Matthew Joseph Iriondo, Warren Lee Boyer, Brian James Soderling, James Eric Davis, Fulvio Rori
  • Publication number: 20240093235
    Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 21, 2024
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Amy Rachel Rappaport, Christine Denise Palmer
  • Publication number: 20240071593
    Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.
    Type: Application
    Filed: October 24, 2023
    Publication date: February 29, 2024
    Inventors: Anna Leigh DAVIS, Scott M. BELLIVEAU, Naresh C. BHAVARAJU, Leif N. BOWMAN, Rita M. CASTILLO, Alexandra Elena CONSTANTIN, Rian W. DRAEGER, Laura J. DUNN, Gary Brian GABLE, Arturo GARCIA, Thomas HALL, Hari HAMPAPURAM, Christopher Robert HANNEMANN, Anna Claire HARLEY-TROCHIMCZYK, Nathaniel David HEINTZMAN, Andrea Jean JACKSON, Lauren Hruby JEPSON, Apurv Ullas KAMATH, Katherine Yerre KOEHLER, Aditya Sagar MANDAPAKA, Samuel Jere MARSH, Gary A. MORRIS, Subrai Girish PAI, Andrew Attila PAL, Nicholas POLYTARIDIS, Philip Thomas PUPA, Eli REIHMAN, Ashley Anne RINDFLEISCH, Sofie Wells SCHUNK, Peter C. SIMPSON, Daniel S. SMITH, Stephen J. VANSLYKE, Matthew T. VOGEL, Tomas C. WALKER, Benjamin Elrod WEST, Atiim Joseph WILEY
  • Publication number: 20240050550
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: October 3, 2022
    Publication date: February 15, 2024
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer
  • Publication number: 20230104840
    Abstract: Methods and compositions for monitoring mutation burden, cancer status, vaccine efficacy using cell-free DNA sequencing are disclosed.
    Type: Application
    Filed: July 8, 2022
    Publication date: April 6, 2023
    Applicant: Gritstone bio, Inc.
    Inventors: James Xin Sun, Matthew Joseph Davis, Desiree Schenk, Daniel Navarro Gomez
  • Publication number: 20230041030
    Abstract: Provided herein are target HLA-PEPTIDE antigens, e.g., HLA-PEPTIDE neoantigens and shared tumor HLA-PEPTIDE antigens, and antigen binding proteins (ABPs) that bind the target HLA-PEPTIDE antigens. Also disclosed are methods for identifying target HLA-PEPTIDE antigens as well as identifying one or more antigen binding proteins that bind a given HLA-PEPTIDE target antigen.
    Type: Application
    Filed: May 13, 2022
    Publication date: February 9, 2023
    Inventors: Karin Jooss, Aleksandra Katarzyna Nowicka, Abubakar Jalloh, Roman Yelensky, James Xin Sun, Jennifer Busby, Matthew Joseph Davis
  • Publication number: 20230020089
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccincation strategy.
    Type: Application
    Filed: May 4, 2022
    Publication date: January 19, 2023
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Jennifer Busby, Brendan Bulik-Sullivan, Mojca Skoberne, Wade Blair
  • Publication number: 20220154281
    Abstract: A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented by class II MHC alleles on surfaces of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequences are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by the class II MHC alleles on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods. T-cells that are antigen-specific for at least one of the neoantigens in the subset are identified. These T-cells can be expanded for use in T-cell therapy. TCRs of these identified T-cells can also be sequenced and cloned into new T-cells for use in T-cell therapy.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 19, 2022
    Inventors: Thomas Francis Boucher, Brendan Bulik-Sullivan, Jennifer Busby, Minh Duc Cao, Matthew Joseph Davis, Lauren Elizabeth Young, Joshua Michael Francis, Christine Denise Palmer, Mojca Skoberne, Roman Yelensky
  • Publication number: 20220155321
    Abstract: Methods are provided to separately isolate antigen-binding T cells and antigen-activated T cells derived from a starting population of peripheral blood mononuclear cells, and to identify overlapping T cell receptor clonotypes. Antigens include personal and shared neoantigens as well as cancer-testis antigens. The T cell receptor clonotypes can be further used to develop cancer treatment therapies.
    Type: Application
    Filed: February 28, 2020
    Publication date: May 19, 2022
    Applicant: Gritstone bio, Inc
    Inventors: Matthew Joseph Davis, Joshua Michael Francis, Abubakar Jalloh, Karin Jooss, Christine Denise Palmer, Mojca Skoberne
  • Publication number: 20200363414
    Abstract: A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented on surfaces of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequences are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by an MHC allele on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods. T-cells that are antigen-specific for at least one of the neoantigens in the subset are identified. These T-cells can be expanded for use in T-cell therapy. TCRs of these identified T-cells can also be sequenced and cloned into new T-cells for use in T-cell therapy.
    Type: Application
    Filed: September 5, 2018
    Publication date: November 19, 2020
    Inventors: Roman Yelensky, Brendan Bulik-Sullivan, Jennifer Busby, Matthew Joseph Davis, Lauren Elizabeth Young, Joshua Michael Francis, Christine Palmer, Mojca Skoberne
  • Patent number: D1022845
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: April 16, 2024
    Assignee: Textron Aviation Inc.
    Inventors: Frank Joseph Rowe, Matthew R. Harrell, David Wayne Davis, Sergio R. Martinez, Brent Todd Coppock