Abstract: A network system is configured to facilitate a safe service coordination environment. The network system detects abnormal user states (e.g., sleepiness, inebriation, etc.) and provides corrective recommendations to those users. To do so, client devices executing an application send information associated with the service to the network system. The network system determines an aggregate set of service characteristics based on the aggregate telematics data. The network system also determines a provider profile for a provider providing service in the environment describing the deviation of the user's driving characteristics from the aggregate service characteristics. Based on the difference between the aggregate characteristics and the user profile, the network system determines the provider state using a state verification process. Based on the determined provider state, the network system determines a set of corrective recommendations and sends the corrective recommendations to the provider device.

Abstract: A network system is configured to facilitate a safe service coordination environment. The network system detects abnormal user states (e.g., sleepiness, inebriation, etc.) and provides corrective recommendations to those users. To do so, client devices executing an application send information associated with the service to the network system. The network system determines an aggregate set of service characteristics based on the aggregate telematics data. The network system also determines a provider profile for a provider providing service in the environment describing the deviation of the user's driving characteristics from the aggregate service characteristics. Based on the difference between the aggregate characteristics and the user profile, the network system determines the provider state using a state verification process. Based on the determined provider state, the network system determines a set of corrective recommendations and sends the corrective recommendations to the provider device.

Abstract: A network computer system verifies users for a network service using verification input provided by existing users. The network computer system may determine a set of existing users of the network service based on information obtained from an information resource of the user's computing device. The network computer system may cause a mobile device of each existing user in the set to output content that includes an identifier of the user requesting verification. The network computer system may detect a response action generated in response to the provided content from at least one existing user of the set. The network computer system may determine an account value based on each detected response action.

Abstract: Disclosed are topical oral compositions comprising a safe and effective amount of an antimicrobial agent in admixture with a pharmaceutically acceptable carrier, the compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and in inhibiting the spread into the bloodstream of pathogenic oral bacteria, associated bacterial toxins and endotoxins, and resultant inflammatory cytokines and mediators. Also disclosed are methods of use of these topical antimicrobial oral compositions to reduce the risk of developing an oral bacteria-induced systemic disease and to promote whole body health in humans and other animals.

Abstract: The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

Abstract: The present invention relates to topical oral care compositions comprising in a pharmaceutically acceptable carrier a safe and effective amount of a host-response modulating agent including one or more of an anti-oxidant and modifier of cell redox status, anti-inflammatory agent, metalloproteinase inhibitor, vitamins and nutrients key to maintenance of a host response balance and inhibitor of activation of NF-kB in combination with one or a mixture of additional oral therapeutic actives selected from antimicrobial/antiplaque agents, biofilm inhibiting agents, antibiotics; analgesics and local anesthetic agents; dentinal desensitizing agents and odor masking agents. The present compositions are effective in treating and preventing bacteria-mediated diseases present in the oral cavity and in mediating host reaction to the presence of pathogenic bacteria in the oral cavity as well as the toxins and endotoxins, inflammatory cytokines and mediators released or prompted by these oral pathogens.

Abstract: The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of chlorite ion to promote and/or enhance whole body health in humans and other animals.

Abstract: The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising an antimicrobial agent, in particular stannous salts, such as stannous fluoride and stannous chloride in combination with a polymeric mineral surface active agent such as condensed polyphosphates or polyphosphonates. In addition to providing a spectrum of intraoral benefits, topical administration of the present compositions to the oral cavity surprisingly provides benefits to systemic health. In particular, the present invention relates to methods of using the present topical oral compositions to reduce the risk in development of cardiovascular disease, stroke, atherosclerosis, diabetes, severe respiratory infections, premature births and low birth weight, post-partum dysfunction in neurologic and developmental functions, and associated increased risk of mortality.

Abstract: The present invention relates to topical oral compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, lozenges (including breath mints), dental implements (such as dental floss and tape), and pet care products comprising at least a minimally effective amount of chlorite ion, wherein the pH of the final composition is greater than 7 and the composition is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing diseases and conditions of the oral cavity such as gingivitis, plaque, periodontal disease, herpetic lesions, and infections that may develop following dental procedures such as osseous surgery, tooth extraction, periodontal flap surgery, dental implantation, and scaling and root planing, in humans and other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.