Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: A powered load-moving tractor unit for moving a wheeled load comprises a tractor body with two powered ground-engaging tractor wheels steerable by a tiller and a draw bar for connecting the tractor body to the load through a releasable load hitch. To steer the load, the tractor body can be moved pivotally about a vertical axis relative to the draw bar. That vertical axis is defined by the two halves of a turntable mounted on the tractor body directly over the axis of rotation of the steerable ground-engaging wheels. The draw bar is rigidly connected over the top half of the turntable and extends down the front of the tractor body to the load hitch. The load hitch comprises telescopically inter-engageable elements on the draw bar and the load, and a latch mechanism that is remotely releasable from the end of the draw bar remote from the load hitch.

Abstract: A powered load-moving tractor unit for moving a wheeled load comprises a tractor body with two powered ground-engaging tractor wheels steerable by a tiller and a draw bar for connecting the tractor body to the load through a releasable load hitch. To steer the load, the tractor body can be moved pivotally about a vertical axis relative to the draw bar. That vertical axis is defined by the two halves of a turntable mounted on the tractor body directly over the axis of rotation of the steerable ground-engaging wheels. The draw bar is rigidly connected over the top half of the turntable and extends down the front of the tractor body to the load hitch. The load hitch comprises telescopically inter-engageable elements on the draw bar and the load, and a latch mechanism that is remotely releasable from the end of the draw bar remote from the load hitch.

Abstract: A steering and handling device (1) for moving a roll cage (100) which has a generally U-shaped base frame (102) with castor wheels (106) at its forward end and fixed wheels at its rearward end (110). The device (1) includes a body (2) defining a steering axis and having channel means (36) extending in cantilever rearwardly of the steering axis. The channel means (36) is for releasably engaging the base frame (102) of the roll cage (100) between the front castor wheels (106). A steering tiller (4) is pivotally mounted on the body (2) and extends forwardly and upwardly from the body (2) and terminates in a handle portion (10). An axle (6) is fast to the steering tiller (4) beneath the body (2) on which wheels (8) are mounted.