Abstract: A full face respirator comprising a mask (10) having a transparent viewing portion (12) and a port portion (16), and exhalation port (22) disposed in said port portion (16), a face seal configured (14) to seal the mask (10) over a wearer's eyes, nose and mouth, in use, and an orinasal assembly (2) including a flexible, cup-shaped orinasal (2) having an orifice (2a) and being configured to fit over a wearer's nose and mouth, in use; wherein the orinasal assembly (2) further includes generally tubular connecting portion (24), integrally formed with and extending outwardly from the periphery of the orifice (2a), the connection portion (24) being shaped and configured to extend through the exhalation port (22) from the inner region to the outer region of the mask (10) and including an exhalation valve mount (28) for receiving a one-way exhalation valve (4).

Abstract: A fold flat personal respiratory device comprising: a generally planar central panel (10) including a layer of filter media and having opposing first and second side edges (12a, 12b) and first and second end edges (11); a first side panel joined to said central panel (10) along said first side edge (12a); a second side panel joined to said central panel (10) along said second side edge (12b); the device being manually configurable from a folded configuration in which said side panels (12a, 12b) are substantially parallel to a planar surface of said central panel (10) and an operational configuration in which said central (10) and first and second side panels (12a, 12b) form a cup-shaped respiratory chamber; the device further comprising a rigid or semi-rigid endoskeleton member (36) mounted along a planar surface of said central panel (10) and extending between said first and second side edges (12a, 12b) and/or said first and second end edges (11).

Abstract: This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome.

Abstract: A full face respirator comprising a mask (10) having a transparent viewing portion (12) and a port portion (16), and exhalation port (22) disposed in said port portion (16), a face seal configured (14) to seal the mask (10) over a wearer's eyes, nose and mouth, in use, and an orinasal assembly (2) comprising a flexible, cup-shaped orinasal (2) having an orifice (2a) and being configured to fit over a wearer's nose and mouth, in use; wherein the orinasal assembly (2) further comprises a generally tubular connecting portion (24), integrally formed with and extending outwardly from the periphery of said orifice (2a), said connection portion (24) being shaped and configured to extend through said exhalation port (22) from the inner region to the outer region of the mask (10) and including an exhalation valve mount (28) for receiving a one-way exhalation valve (4).

Abstract: A fold flat personal respiratory device comprising: a generally planar central panel (10) including a layer of filter media and having opposing first and second side edges (12a, 12b) and first and second end edges (11); a first side panel joined to said central panel (10) along said first side edge (12a); a second side panel joined to said central panel (10) along said second side edge (12b); the device being manually configurable from a folded configuration in which said side panels (12a, 12b) are substantially parallel to a planar surface of said central panel (10) and an operational configuration in which said central (10) and first and second side panels (12a, 12b) form a cup-shaped respiratory chamber; the device further comprising a rigid or semi-rigid endoskeleton member (36) mounted along a planar surface of said central panel (10) and extending between said first and second side edges (12a, 12b) and/or said first and second end edges (11).