Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for the treatment of diseases associated with IL-22 (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn's disease (CD)) and graft versus host disease (GVHD) (e.g., acute or chronic GVHD)).

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).

Abstract: The invention relates to IL-22 Fc fusion proteins, composition comprising the same, methods of making and/or purifying the same, methods of selecting batches of IL-22 Fc fusion proteins or compositions thereof, and methods of using the composition for the treatment of diseases (e.g., IBD).

Abstract: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Abstract: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Abstract: The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Abstract: A computer Input/Output system having a fabric, a control unit (CU) and a host computer including a channel, the channel having a channel port connected by a first link to a channel neighbor port of the fabric, and the control unit having a CU port connected by a second link to a CU neighbor port on the fabric. Then an error is detected in the link or protocol between the channel and the control unit, error data are reported to the channel by the channel, the channel port, the channel neighbor port, the control unit, the CU port and the CU neighbor port and sent to the channel. The error data are provided to the host computer for analysis.

Abstract: Provided are a method, system, and article of manufacture for providing an address format compatible with different addressing formats used for addressing different sized address spaces. An address format is used in an operating system to address storage space in a storage device comprising a first region and a second region of storage space. A first group of applications uses the address format to only address the storage space in the first region and is not coded to use the address format to access the second region and a second group of applications uses the address format to address the storage space in the first and second regions.

Abstract: Provided are techniques for spare device management. Candidate devices are sorted into spare coverage groups by type. One or more candidate devices having closest fitting characteristics of a desired type are identified from the spare coverage groups. The identified one or more candidate devices are assigned to be spare devices for the spare coverage group. It is determined whether a desired number of spare devices have been assigned to the spare coverage group. In response to determining that the desired number of spare devices have not been assigned, a spare device having the closest fitting characteristics for every predetermined number of candidate devices having the closest fitting characteristics is assigned, until the desired number of spare devices having the closest fitting characteristics are assigned.

Abstract: Provided are a method, system, and program for initiating and using information used for a host, control unit, and logical device connections receiving a request to create a host port to control unit port connection. In a volume group data structure, a volume group entry is defined having a plurality of pointers for the host port and control unit port pair. At least one device address is added to the volume group that is accessible to the host port and control unit port connection by initializing at least one pointer in the volume group entry to address at least one device data structure. For each of the at least one device addresses, indication is made in the at least one device data structure addressed by the at least one pointer in the volume group entry that the device address is accessible to the host port and control unit port connection.

Abstract: An apparatus, system, and method are disclosed for concurrently relocating a RAID array. The apparatus includes an identification module, a designation module, and an implementation module. The identification module identifies an availability of a physical device within a donor arrayed storage device to offload a source drive of a relocation enclosure. The designation module designates an available physical device as a target drive and thereby designate the target drive and the source drive as a linked pair;. The implementation module implements a mirroring relationship between the target drive and the source drive. The apparatus, system, and method provide a dynamic relocation of the raid array, minimizing system downtime and maximizing efficient utilization of system resources.

Abstract: An apparatus and method are disclosed to configure, format, and test, a data storage subsystem product. The method supplies a data storage subsystem product comprising one or more host computer ports, a processor, one or more data storage device ports, and one or more data storage devices interconnected to the one or more data storage device ports. The method further supplies a configuration appliance comprising a storage configuration. The method connects the configuration appliance to one of the one or more storage device ports, boots up the data storage subsystem product, discovers the configuration appliance by the data storage subsystem product, imports storage configuration data into the data storage subsystem product, formats the one or more data storage device, and tests the input and output data transfer rates for the data storage subsystem product, wherein the formatting and testing are initiated concurrently.

Abstract: Provided are a method, system, and article of manufacture for assigning alias addresses to base addresses. An assignment is provided of base addresses to the devices, wherein the base addresses are used to access the devices assigned to the base addresses. An assignment is provided of a plurality of alias addresses to an alias address pool. The alias addresses in the alias address pool are capable of being dynamically assigned to the devices to service I/O requests to the devices. An Input/Output (I/O) request to access one target device comprising one of the devices is processed. A determination is made as to whether the base address assigned to the target device is available. One alias address is assigned to the target device in response to determining that the base address is not available. The I/O request is issued to the assigned alias address to transmit the request to the target device.

Abstract: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

Abstract: Computer networks are provided with a resource efficient ability to generate link performance statistics. To calculate the average link utilization per I/O operation, a first counter accumulates the number of I/O operations processed by a link and a second counter accumulates the time required by the link to complete each I/O operation. The second value is then divided by the first value. The number of operations per second for a link may be computed by dividing the first number by a predetermined period of time and the average number of operations using the link may be computed by dividing the second number by the predetermined period of time. A third counter may be employed to accumulate the number of bytes transferred by a link during each I/O operation. Then, average size of an I/O operation may be computed by dividing the third number by the first number and the average bandwidth per link operation may be computed by dividing the third number by the predetermined period of time.

Abstract: A system for coordinating error tracking, level setting and reporting among the various layers/components of a distributed storage system. Each component of the distributed system includes a trigger generation and response (TGR) utility, which generates an error tracking trigger (ETT), comprising: (1) an action that the initiator wants the stack's error tracking mechanisms to take; (2) a message that the initiator wants the stack to immediately post in its logs; and (3) a route/direction that the trigger is to be transmitted through the stack. The ETT is transmitted one layer at a time through the stack, and each intervening layer of the stack is equipped with a utility to examine the ETT and take the appropriate action(s), designated by the trigger. An error log is maintained by each layer of the stack and used to record information about the error and enable user determination of the source, timing and cause of errors.

Abstract: An apparatus, system, and method are disclosed for accessing a preferred path through a storage controller. A request module receives a request from a host to identify a preferred path from the host to a control unit image. A response module reports the preferred path to the host. A connection module connects the host through the preferred path to the control unit image. In one embodiment, a detection module detects a failure of a first interconnection module comprising the preferred path. The connection module may re-connect the host to the control unit image through a non-preferred path comprising a second interconnection module in response to the failure of the first interconnection module.

Abstract: A communication-path management system includes a path-detection component for identifying all communications paths between a host computer, through a controller, to a data storage device. Once identified, the communication paths are incorporated into a logical-path mask. The path-detection component recognizes each path as either preferred or non-preferred based on latency, bandwidth, availability, or other user-defined criteria and divides the logical-path mask into a preferred path subset and a non-preferred path subset. If a valid path exists in the preferred path subset, all communications from the host computer to the data storage device transit paths belonging to this subset. Otherwise, active control is given to the non-preferred path subset. A channel subsystem manages actual communication based on resource allocation and contention using the currently active subset.

Abstract: A method, apparatus, and computer instructions for controlling data flow. A control message is formed for the data flow in response to an event while the data flow is occurring. The control message includes a data type, an action, and a duration. The control message is sent to a receiver data processing system, wherein the receiver data processing system modifies the data flow to the data processing system using the control message.