Abstract: Described are systems and methods for directly monitoring the conductivity of the coolant used to regulate the temperature of a fuel cell. The system includes a coolant loop that acts as a conduit for the coolant, an ion exchanger configured to deionize the coolant, and a conductivity sensor configured to output an electrical signal indicating a conductivity of the coolant. The system also includes a processor in communication with the conductivity sensor and a memory having instructions that, when executed by the processor, cause the processor to determine the conductivity of the coolant based on the electrical signal from the conductivity sensor and determine when the ion exchanger requires servicing based on the conductivity of the coolant.

Abstract: Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.

Abstract: Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Abstract: A processing system includes a plurality of compute units, with each compute unit having an associated first cache of a plurality of first caches, and a second cache shared by the plurality of compute units. The second cache operates to manage transfers of caches between the first caches of the plurality of first caches such that when multiple candidate first caches contain a valid copy of a requested cacheline, the second cache selects the candidate first cache having the shortest total path from the second cache to the candidate first cache and from the candidate first cache to the compute unit issuing a request for the requested cacheline.

Abstract: Technology for generating and displaying a graphical user interface for operating an unmanned aerial vehicle (UAV) is disclosed herein that generates and updates a representation of a spline flight path. In various implementations, a graphical user interface detects user interactions with a remote control device directing the flight control subsystem of the UAV to record keyframes and to compute a spline based on the keyframes during flight. The graphical user interface displays a real-time perspective of the UAV with a representation of the spline and the keyframes overlaying the view. The graphical user interface continually updates the representation as the UAV flies and when the spline is updated as the keyframes are updated.

Abstract: Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.

Abstract: Methods and systems for providing processed cocoa nibs are provided. The methods involve coarse grinding cocoa nibs to form a slurry and subjecting less than all of the cocoa slurry to refining. The refined and unrefined volumes or portions of cocoa slurry are then recombined to provide a recombined cocoa product. The cocoa nibs produced by the method may be further processed to provide cocoa liquor or chocolate.

Abstract: An embodiment of a heat exchanger assembly includes a first manifold adapted for receiving a first medium, a core adapted for receiving and placing a plurality of mediums, including the first medium, in at least one heat exchange relationship, and a core meeting the first manifold at a first core/manifold interface; The mounting structure supports a heat exchanger, and is metallurgically joined to at least one heat exchanger assembly component at a first joint integrally formed with the mounting structure.

Abstract: Disclosed herein are systems and methods for multiplex primer design and selection. In one example, a system includes non-transitory memory configured to store executable instructions; and a hardware processor programmed by the executable instructions to receive a plurality of target gene sequences and determine a set of primers for each target gene sequence based on a penalty score associated with the set of primers, wherein the penalty score is based on a non-linear combination of a primer-level penalty score and a set-level penalty score.

Abstract: An embodiment of a heat exchanger assembly includes a first manifold adapted for receiving a first medium, a core adapted for receiving and placing a plurality of mediums, including the first medium, in at least one heat exchange relationship, and a core meeting the first manifold at a first core/manifold interface; The mounting structure supports a heat exchanger, and is metallurgically joined to at least one heat exchanger assembly component at a first joint integrally formed with the mounting structure.

Abstract: Computer methods and systems for quantifying a nucleic acid sample comprising nucleic acid of one or more contributors to: receive nucleic acid sequence reads obtained from the nucleic acid sample and mapped to alleles at polymorphism loci; determine, using the nucleic acid sequence reads, allele counts for each of the alleles at the polymorphism loci; use a probabilistic mixture model that applies a probabilistic mixture model to the allele counts, and that uses probability distributions to model the allele counts at the polymorphism loci; quantify, using the probabilistic mixture model, one or more fractions of nucleic acid of the one or more contributors in the nucleic acid sample; determine a probability that a specific contributor among the one or more contributors has a specific genotype; and call, based on the posterior probability, that the nucleic acid sample includes nucleic acid from the specific contributor.

Abstract: An embodiment of a heat exchanger assembly includes a first manifold adapted for receiving a first medium, a core adapted for receiving and placing a plurality of mediums, including the first medium, in at least one heat exchange relationship, and a core meeting the first manifold at a first core/manifold interface; The mounting structure supports a heat exchanger, and is metallurgically joined to at least one heat exchanger assembly component at a first joint integrally formed with the mounting structure.

Abstract: Methods and systems for providing processed cocoa nibs are provided. The methods involve coarse grinding cocoa nibs to form a slurry and subjecting less than all of the cocoa slurry to refining. The refined and unrefined volumes or portions of cocoa slurry are then recombined to provide a recombined cocoa product. The cocoa nibs produced by the method may be further processed to provide cocoa liquor or chocolate.

Abstract: A counter-flow heat exchanger core includes a first wall defining a longitudinal axis. The first flow path is defined within the first wall. The first flow path includes a primary flow inlet and a primary flow outlet downstream from the primary flow inlet. The heat exchanger core includes at least two hollow vanes circumferentially spaced apart and extending in a radially inward direction from the first wall. Each of the at least two hollow vanes includes a first vane wall and a second vane wall. The heat exchanger core includes a second flow path defined within the at least two hollow vanes between the first vane wall and second vane wall of each of the at least two hollow vanes. The heat exchanger core includes at least one fin extending between two of the at least two circumferentially spaced apart vanes.

Abstract: A seat pan adjustment system for an ejection seat may comprise a guide bracket defining a channel and a seat pan mount configured to translate relative to the guide bracket. A support bracket may extend from a surface of the seat pan mount. A rod may be located through a rod opening defined by the support bracket. The rod may be located in the channel. A biasing member may be coupled to the rod and configured to force the rod away from the surface of the seat pan mount.

Abstract: Methods and systems for providing processed cocoa nibs are provided. The methods involve coarse grinding cocoa nibs to form a slurry and subjecting less than all of the cocoa slurry to refining. The refined and unrefined volumes or portions of cocoa slurry are then recombined to provide a recombined cocoa product. The cocoa nibs produced by the method may be further processed to provide cocoa liquor or chocolate.

Abstract: Respirator masks may include a respirator mask body and a respirator mask gasket. The respirator mask body may include a plurality of openings for the exchange of gas and an air filtration media configured to filter particles from air passing into and out of the respirator mask body. The respirator mask gasket may be coupled to the respirator mask body and may be sized and shaped responsively to a three-dimensional scan of a portion of user's face including the user's nose and mouth and being configured to closely abut the user's face when worn. A combination of respirator mask body and respirator mask gasket may be positioned within a donning mechanism that facilitates positioning of the combined respirator mask body and respirator mask gasket over the user's face and retention thereon.

Abstract: A seat pan adjustment system for an ejection seat may comprise a guide bracket defining a channel and a seat pan mount configured to translate relative to the guide bracket. A support bracket may extend from a surface of the seat pan mount. A rod may be located through a rod opening defined by the support bracket. The rod may be located in the channel. A biasing member may be coupled to the rod and configured to force the rod away from the surface of the seat pan mount.

Abstract: Methods and systems are provided for quantifying and deconvolving nucleic acid mixture samples including nucleic acid of one or more contributors having known or unknown genomes. The methods and systems provided herein implement processes that use Bayesian probabilistic modeling techniques to determine the abundances and confidence intervals of genetically distinct contributors in a chimerism sample, thereby improving specificity, accuracy and sensitivity, and greatly expanded the application scope over conventional methods.

Abstract: Disclosed herein are systems and methods for multiplex primer design and selection. In one example, a system includes non-transitory memory configured to store executable instructions; and a hardware processor programmed by the executable instructions to receive a plurality of target gene sequences and determine a set of primers for each target gene sequence based on a penalty score associated with the set of primers, wherein the penalty score is based on a non-linear combination of a primer-level penalty score and a set-level penalty score.