Abstract: A test system is provided for a component of an engine. This test system includes a combustor test section and an air system. The combustor test section includes a fuel injector, an ignitor and a combustion chamber. The fuel injector is configured to direct fuel into the combustion chamber for mixing with cooled air. The ignitor is configured to ignite a mixture of the fuel and the cooled air within the combustion chamber. The air system is configured to deliver the cooled air to the combustor test section. The air system includes a compressed air source, a cryogenic cooling system and an air circuit. The cryogenic cooling system includes a cryogenic heat exchanger. The air circuit extends through the cryogenic heat exchanger and fluidly couples the compressed air source to the combustor test section.

Abstract: A dispenser assembly having a base member and a receptacle. The base member has a bowl. The receptacle has a dispensing opening defined at the first end thereof. The receptacle is configured to fit on to the base member such that the dispensing opening is positioned to dispense contents of the receptacle into the bowl of the base member in an in-use orientation. The receptacle is dimensioned and shaped to at least partially fit into the bowl in a stowed orientation such that in the stowed orientation the receptacle and base member occupy a volume that is less than a volume corresponding to the in-use orientation.

Abstract: The disclosure is based on the finding that microwave energy may be used to modulate, for example up- or down-regulate the expression of certain genes. For example, where a disease or condition is associated with the aberrant expression of a particular gene or genes, microwave energy may be used to modulate the expression of those genes, thereby resolving and/or improving one or more of the symptoms of the disease or condition. Disclosed is a microwave system or microwave-generating apparatus, for use in a method of modulating the expression of one or more genes. Also disclosed are uses of microwave energy for modulating the expression of one or more genes in tissues, tissue samples and biopsies.

Abstract: A microwave system comprises: a microwave generator; a controller configured to control the microwave generator to generate microwave energy having a selected operational frequency or range of frequencies; a microwave cable configured to deliver the microwave energy to a microwave antenna extending from or coupled to a distal end of the microwave cable; and the microwave antenna, the microwave antenna comprising a plurality of slots distributed along a portion of the microwave antenna, wherein a width of the slots varies with distance along the portion of the microwave antenna.

Abstract: The present disclosure provides compositions, medicaments and methods for treating or preventing disorders, conditions and/or diseases affecting keratinised structures or tissues such as, for example, nails.

Abstract: A microwave system, comprises: a microwave generator; a microwave applicator for delivering microwave radiation generated by the microwave generator to a surface, wherein the microwave applicator is moveable relative to the surface; one or more sensors for sensing at least one of a position, an orientation, an acceleration, a speed and/or a velocity of the microwave applicator, and a controller configured to monitor sensor output from the one or more sensors and further configured to control one or more operational parameters of the microwave system based at least on the monitored sensor output.

Abstract: A microwave antenna apparatus comprises a radiating element configured to perform a treatment, the treatment comprising heating a volume of tissue using microwave radiation emitted from the radiating element; a cooling structure arranged for flowing a coolant through at least one lumen of the cooling structure during the treatment; and a controller configured to control the flow of coolant such as to provide a first flow rate of coolant through the at least one lumen during a first period of the treatment and to provide a second, different flow rate of coolant through the at least one lumen during a second, later period of the treatment.

Abstract: The present disclosure provides microwave-based methods for the modulation of certain genes and immunomodulatory factors. The various methods described herein may be used to modulate the expression of one or more genes thought to be beneficial in and/or associated with, the treatment and/or prevention of a disease and/or condition of the skin.

Abstract: A microwave system comprises: a microwave generator; and a microwave cable apparatus comprising a coaxial cable, wherein an exposed distal portion of an inner conductor of the coaxial cable is longer than an outer conductor of the coaxial cable, and wherein at least part of the exposed distal portion of the inner conductor is bent with respect to a longitudinal axis of the coaxial cable, thereby to provide a directional radiating element; wherein the microwave generator is configured to provide microwave energy to the cable apparatus at a frequency that provides directional radiation of microwave energy having a desired directionality from the radiating element.

Abstract: Described herein are methods and apparatus for treating or preventing epidermal dysplasias, including, for example, dysplastic epidermal lesions and dermatological pre-cancerous disease.

Abstract: Described herein are methods and apparatus for the treatment of melanoma skin cancer.