Abstract: Described herein, among other things, is a fusion protein for degrading a target protein in trans. The fusion protein may comprise a lysine-free alpha-helical heterodimerization domain and a C-terminal degron. Degrons are believed to act as a degradation signal that recruits the proteosome to the target protein, thereby degrading the protein. A nucleic acid encoding the same and a cell containing the nucleic acid and a target protein are also described.

Abstract: Described herein is a cell comprising a feedback circuit. In some embodiment, the circuit may comprise: (a) a first polypeptide that is activated by an external stimulus and, downstream from the first polypeptide: (b) a target protein and (c) a fusion protein comprising: (i) a domain that binds to the target protein of (b) and (ii) a degron or E3 ligase-recruiting domain. In these embodiments, the first polypeptide of (a), in its activated form, independently activates the expression of (b) and (c); and the fusion protein of (c) binds to the first polypeptide of (a), thereby causing degradation of the first polypeptide in trans. Methods using the cell are also provided.

Abstract: A storage system including a plurality of HDDs, a cooling system, and a system controller is provided. Each of the plurality of HDDs includes a disk, a write head configured to write data to the disk, a microphone, an HDD controller configured to process a signal from the microphone determine noise detected by the microphone, and a housing that houses the disk, the write head, the microphone, and the HDD controller. The cooling system is configured to cool the plurality of the HDDs. The system controller is configured to receive data corresponding to the determined noise detected by the microphones of each of the plurality of HDD, and control a cooling level of the cooling system based on the received data and acoustic noise information associated with each of the plurality of HDDs. A method for operating the storage system is also provided.

Abstract: Provided herein is cleavable fusion protein comprising: an extracellular binding domain comprising a first protein binding domain that specifically binds to a cell surface protein, a transmembrane domain, one or more force-dependent cleavage sites and an intracellular domain comprising: i. a second protein binding domain that specifically binds to a target protein; and ii. a degradation domain. When the fusion protein is expressed in a mammalian cell, binding of the first binding domain to the cell surface protein induces proteolytic cleavage of the one or more force-dependent cleavage site to release the intracellular domain. Protein circuits, cells and methods that make use of the fusion protein are also provided.

Abstract: Provided herein is a fusion protein comprising: (a) an extracellular domain comprising a first binding moiety that is capable of specifically binding to a first cell surface marker: (b) a transmembrane domain: and (c) an intracellular domain comprising: i. a first dimerization domain that specifically binds to a corresponding target dimerization domain in a target protein: and ii. a degradation domain, wherein the degradation domain is a degron or E3 ligase-recruiting domain. Protein circuits. cells and methods that make use of the fusion protein are also provided.

Abstract: Examples described herein include systems and methods for prioritizing workloads, such as virtual machines, to enforce quality of service (“QoS”) requirements. An administrator can assign profiles to workloads, the profiles representing different QoS categories. The profiles can extend scheduling primitives that can determine how a distributed resource scheduler (“DRS”) acts on workloads during various workflows. The scheduling primitives can be used to prioritize workload placement, determine whether to migrate a workload during load balancing, and determine an action to take during host maintenance. The DRS can also use the profile to determine which resources at the host to allocate to the workload, distributing higher portions to workloads with higher QoS profiles. Further, the DRS can factor in the profiles in determining total workload demand, leading to more efficient scaling of the cluster.

Abstract: Provided herein is a fusion protein comprising: (a) an extracellular domain comprising a first binding moiety that is capable of specifically binding to a first cell surface marker: (b) a transmembrane domain: and (c) an intracellular domain comprising: i. a first dimerization domain that specifically binds to a corresponding target dimerization domain in a target protein: and ii. a degradation domain, wherein the degradation domain is a degron or E3 ligase-recruiting domain. Protein circuits. cells and methods that make use of the fusion protein are also provided.

Abstract: A board game assembly includes a game board that has game board indicia printed thereon comprising imagery of a floor plan of a house. A plurality of identity boards is provided and each of the identity boards is assigned to a respective player. A pair of dice is provided for rolling during the course of game play. A plurality of playing cards is provided which includes a set of hint cards, a set of character cards, a set of ability cards, a set of quest cards and a set of memory cards. A selected number of the playing cards is dealt to each of the respective players and is positioned on a respective card location on the identity board that is assigned to the respective player. A plurality of game pieces is each assigned to a respective player and each of the game pieces is positionable on the game board to indicate a location of a character assigned to the respective player.

Abstract: Described herein is a therapeutic cell that expresses a fusion protein comprising: (a) a target-binding domain; and (b) a degradation domain, e.g., a degron or E3 ligase-recruiting domain, that is heterologous to the target-binding domain. In the therapeutic cell, binding of the fusion protein to a target protein via the target-binding domain induces degradation of the target protein. The therapeutic cell can be an immunostimulatory cell, an immunoinhibitory cell or a stem cell, for example. Methods of treatment using the cell are also provided.

Abstract: Aspects of workload reallocation within a software-defined data center (SDDC) undergoing an upgrade are described. As upgrades become available for services and other types of applications installed on a cluster of host devices within a data center, an upgrade of the installed services may be required for each of the host devices. During a cluster upgrade, the order in which hosts in the cluster are upgraded is determined as a function of evacuation costs and evacuation policies associated with each host device in the computing cluster. In addition, a maintenance cost associated with a workload needing to be evacuated from a host undergoing an upgrade is determined based on the upgrade sequence. The maintenance cost can then be used as a factor for selecting an optimal candidate host for migrating the workload to when the host the workload is currently running on is being upgraded.

Abstract: Examples described herein include systems and methods for prioritizing workloads, such as virtual machines, to enforce quality of service (“QoS”) requirements. An administrator can assign profiles to workloads, the profiles representing different QoS categories. The profiles can extend scheduling primitives that can determine how a distributed resource scheduler (“DRS”) acts on workloads during various workflows. The scheduling primitives can be used to prioritize workload placement, determine whether to migrate a workload during load balancing, and determine an action to take during host maintenance. The DRS can also use the profile to determine which resources at the host to allocate to the workload, distributing higher portions to workloads with higher QoS profiles. Further, the DRS can factor in the profiles in determining total workload demand, leading to more efficient scaling of the cluster.

Abstract: Examples described herein include systems and methods for prioritizing workloads, such as virtual machines, to enforce quality of service (“QoS”) requirements. An administrator can assign profiles to workloads, the profiles representing different QoS categories. The profiles can extend scheduling primitives that can determine how a distributed resource scheduler (“DRS”) acts on workloads during various workflows. The scheduling primitives can be used to prioritize workload placement, determine whether to migrate a workload during load balancing, and determine an action to take during host maintenance. The DRS can also use the profile to determine which resources at the host to allocate to the workload, distributing higher portions to workloads with higher QoS profiles. Further, the DRS can factor in the profiles in determining total workload demand, leading to more efficient scaling of the cluster.

Abstract: An example method for an infrastructure management server to manage virtual infrastructure objects in a cluster is disclosed. The example method includes configuring the infrastructure management server to perform a function on the virtual infrastructure objects in the cluster, identifying a set of virtual infrastructure objects out of the virtual infrastructure objects that are tagged, identifying a customized policy associated with the first set of virtual infrastructure objects, and modifying the function based on the customized policy.

Abstract: Examples described herein include systems and methods for prioritizing workloads, such as virtual machines, to enforce quality of service (“QoS”) requirements. An administrator can assign profiles to workloads, the profiles representing different QoS categories. The profiles can extend scheduling primitives that can determine how a distributed resource scheduler (“DRS”) acts on workloads during various workflows. The scheduling primitives can be used to prioritize workload placement, determine whether to migrate a workload during load balancing, and determine an action to take during host maintenance. The DRS can also use the profile to determine which resources at the host to allocate to the workload, distributing higher portions to workloads with higher QoS profiles. Further, the DRS can factor in the profiles in determining total workload demand, leading to more efficient scaling of the cluster.

Abstract: A thermal transfer system for reducing temperature cycling of an electronic device. The thermal system includes a thermally conductive device to which the electronic device is mounted, a heat sink and a thermal rail mounted to the heat sink. The thermal system further includes a plurality of shape memory alloy (SMA) elements extending through aligned openings in the rail and the thermally conductive device, where the SMA elements are shaped in a deformed wire-like configuration and attempt to return to an undeformed spring-like configuration when the plurality of SMA elements are heated above a transition temperature so as to increase a heat transfer contact pressure between the thermally conductive device and the rail.

Abstract: A display device is disclosed. The display device includes a hinge module comprising a pair of hinge shafts arranged side by side, a pair of hinge brackets having one ends coupled to the hinge shafts, respectively, and the other ends in which slide slots are formed, a pair of slide brackets coupled to the slide slots, the slide brackets which are horizontally movable along the slide slots, and a pair of bodies coupled to the slide brackets, respectively, such that the display device may be foldable 0˜180 degrees to be folded and unfolded like a book.

Abstract: A display device is disclosed. The display device includes a hinge module comprising a pair of hinge shafts arranged side by side, a pair of hinge brackets having one ends coupled to the hinge shafts, respectively, and the other ends in which slide slots are formed, a pair of slide brackets coupled to the slide slots, the slide brackets which are horizontally movable along the slide slots, and a pair of bodies coupled to the slide brackets, respectively, such that the display device may be foldable 0˜180 degrees to be folded and unfolded like a book.

Abstract: A manufacturing method for producing a plurality of polymeric drawtape bags, the method including: a) dispensing a film of polymeric pliable material; b) producing a web of folded and sealed polymeric panels from the film, the web including a plurality of polymeric bags having a pair of drawtapes added into a pair of hems proximate a bag opening with a series of notches produced near lateral edges of each of the hems exposing the drawtapes with a series of lateral seals applied to the exposed drawtapes within the notches; c) measuring a relative placement of the series of notches with respect to the seals; and d) providing feedback to a notch production system to improve placement of the series of lateral seals of the exposed drawtapes within the notches by accurately locating the series of notches produced along the web.

Abstract: A multipurpose of multifunction container device is provided that has a body defining at least one storage compartment to contain one or more items therein and a housing section that is designed to contain one or both of: a cutter device useful to cut the tip of items contained in the storage compartment (or other items) and an implement, such as a lighter, flashlight, compass, etc.

Abstract: A McPherson strut system and double wishbone suspension system is adapted to provide adjustable camber of the suspended wheel responsive to steering of the vehicle. The upper member of a McPherson strut or the upper link of a double wishbone is provided with a slide permitting horizontally supported freedom of movement with respect to the chassis. By providing a link through the slide to the kingpin, camber adjustment responsive to steering motion is attained for McPherson and double wishbone suspensions. The camber adjusting apparatus for steered wheels of a vehicle has a wheel support for each steered wheel that rotatably mounts the wheel and is pivotable about a generally horizontal axis that is transverse to an axis of rotation of the wheel.