Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: A facility for optimizing machine learning models is described. The facility obtains a description of a machine learning model and a hardware target for the machine learning model. The facility obtains optimization result data from a repository of optimization result data. The facility optimizes the machine learning model for the hardware target based on the optimization result data.

Abstract: A robotic surgical instrument includes an articulation drivable by at least one driving element. Movement of an instrument interface element is transferred to the at least one driving element. A driving element securing member includes at least one tapered side wall and is configured to be coupled to the at least one driving element. A holding member includes an opening configured to receive a fixing member and at least one wall defining a recess having a shape complementary to the shape of the at least one tapered side wall. The fixing member is configured to be received in the opening and apply force to secure the driving element securing member within the recess of the holding member so that the at least one wall of the holding member is in frictional contact with the tapered side wall of the driving element securing member.

Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods.

Abstract: A system has data capture devices collecting data from different points in a network. The captured data is written to a data store and is directed to an output. The data from the different data capture devices can be delivered to a data analytics device. As long as the data analytics device is able to keep pace with the data that is directed to the output, that data is used by the analytics device. If the analytics device is not able to keep pace, the data written to the data store is retrieved and is used until the analytics device has caught up.

Abstract: A method for remotely signalling a downhole assembly comprising one or more downhole tools includes operating a choke arrangement configured to control production fluid flow from a wellbore to produce a first pressure signature in the fluid flow, the first pressure signature defining a trigger signal for the one or more downhole tools of the downhole assembly. The first pressure signature comprises at least a first pressure signal and a second pressure signal in the production fluid flow in the downhole assembly. Operating the choke arrangement to produce a second pressure signature in the production fluid flow in the downhole assembly at a predetermined time period following the first pressure signature, the second pressure signature defining a command signal for initiating operation of a predetermined one or more of the downhole tools of the downhole assembly.

Abstract: The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods.

Abstract: The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods.

Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis using a nucleoside triphosphate-3?-O-removable blocking group (NTP-3?-O-RBG), as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.

Abstract: A surgical robot system comprising: a surgical robot, the surgical robot comprising a base, and an arm extending from the base to an attachment for an instrument the arm comprising a plurality of joints whereby the configuration of the arm can be altered; an instrument attached to the arm of the surgical robot; and a control unit configured to receive one or more inputs from an operator of the surgical robot in relation to movement of the instrument and translate the one or more inputs into one or more control signals in accordance with a set of control parameters to control the movement of the instrument, the set of control parameters being one of one or more sets of control parameters associated with the operator.

Abstract: There is provided a flavour system for use in a tobacco industry product. The flavour system comprises lyophilised botanical material, an activator capable of releasing flavourant from the lyophilised botanical material through contact of the activator with the lyophilised botanical material, and a removable barrier preventing contact between the lyophilised botanical material and the activator. The barrier is removable to permit the activator to contact the lyophilised botanical material, thereby to cause release of the flavourant.

Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: A system or apparatus for use in downhole communication or detection comprises a downhole arrangement defining a throughbore and primary and secondary elements. One of the primary and secondary elements is provided on the downhole arrangement and the other of the primary and secondary elements is provided in the throughbore. The primary and secondary elements are configurable for coupling of an electromagnetic field therebetween. The primary or secondary element which is provided in the throughbore may be provided on a tool such as a shifting tool which is deployable through the throughbore. The secondary element may be configured to provide the electromagnetic field coupled between the first and second elements with one or more characteristic features. The system may be configured for use, in particular though not exclusively, for communicating information to and/or from a downhole tool in an oil or gas well.

Abstract: There is provided a flavour system for use in a tobacco industry product. The flavour system comprises lyophilised botanical material, an activator capable of releasing flavourant from the lyophilised botanical material through contact of the activator with the lyophilised botanical material, and a removable barrier preventing contact between the lyophilised botanical material and the activator. The barrier is removable to permit the activator to contact the lyophilised botanical material, thereby to cause release of the flavourant.

Abstract: A filter for a smoking article has a first filter section comprising a filter material and a smoke modifying additive disposed in an axial region thereof and a second filter section connected to the first filter section and having at least one channel located in an axial region thereof for directing smoke, in use, through the axial region of the first filter section. The smoke modifying additive can comprise a flavourant such as menthol and the second filter section can comprise a tubular section of fibrous filter material. An adsorbent filter section can also be provided.

Abstract: A first RFID tag arrangement for actuating a downhole tool includes a non-metallic housing enclosing a passive RFID tag, power source, pulsed oscillator circuit, and energizer coil. The pulsed oscillator circuit drives the energizer coil to stimulate and activate the tag such that it can be read by an external reader. A second RFID tag arrangement includes a non-metallic housing enclosing a power source, a transmission circuit, and a transmitter coil. The transmission circuit can drive the transmitter coil to transmit a payload stored in the transmission circuit such that the payload is delivered to an external reader. A method of actuating a downhole tool includes placing the tool's RFID tag reader in listen only mode, introducing into the wellbore an active RFID tag that transmits its payload to the reader, and optionally configuring the reader to reprogram the tag when it receives the payload therefrom.

Abstract: A filter for a smoking article has a first filter section comprising a filter material and a smoke modifying additive disposed in an axial region thereof and a second filter section connected to the first filter section and having at least one channel located in an axial region thereof for directing smoke, in use, through the axial region of the first filter section. The smoke modifying additive can comprise a flavourant such as menthol and the second filter section can comprise a tubular section of fibrous filter material. An adsorbent filter section can also be provided.

Abstract: The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods.

Abstract: A server receives a request for a business account with the messaging system that includes a business name and a contact point. The server determines whether users of the messaging system associate the business name with the contact point. The server also determines whether the business name and/or the contact point has characteristics consistent with the request originating from a genuine business. The business account is validated if users of the messaging system associate the business name with the contact point and at least one of the business name or the contact point have characteristics consistent with the request originating from a genuine business. The business account profile is updated to indicate it is verified. Client devices are adapted to display messages from the business account in conjunction with a visual indicator that the business account is verified.