Abstract: A computer-implemented method for creating optimized synthetic backup images may include (1) transferring a backup image that represents a virtual machine at a specific point in time to a server that stores the backup image, (2) identifying a subsequent backup image that represents at least a portion of the virtual machine at a subsequent point in time, (3) creating a data stream that includes (i) at least one changed data block captured in the subsequent backup image and (ii) at least one reference that identifies where at least one unchanged data block is located within the backup image stored on the server, and then (4) transferring the data stream to the server to enable the server to create an optimized synthetic backup image of the virtual machine. Various other methods, systems, and computer-readable media are also disclosed.