Abstract: Disclosed herein are various embodiments of a multi-chamber syringe module for use in fine needle aspiration or other procedures. The multi-chamber syringe module includes a multi-chamber cartridge. The multi-chamber cartridge can include a plurality of fluid chambers. The multi-chamber syringe module also includes a needle manifold that is rotatably coupled to the multi-chamber cartridge. The multi-chamber syringe module further includes a luer fitting hub fixedly coupled to the needle manifold at a first end and selectively coupled to a biopsy needle at a second end.