Abstract: The present invention provides compounds and methods of use thereof for assessing target engagement for DNA polymerase theta. In particular, provided herein are tracer compounds comprising a small molecule that binds DNA polymerase theta tethered to a fluorophore, and methods of use thereof in target engagement assays.

Abstract: The present disclosure is directed to devices and methods for synchronizing capturing of spectral images, capturing of thermal images, and capturing of panchromatic images. A thermal imaging device of an aerial vehicle captures a sequence of thermal images. Capturing of spectral images by a spectral imaging device of the aerial vehicle is synchronized with the capturing of the thermal images. Capturing of panchromatic images is synchronized with the capturing of thermal images. Irradiance data indicative of a background temperature is sensed. A digital surface model of an area of interest is generated based on the sequence of spectral images. An emissivity of a target is estimated and a temperature of a pixel of the digital surface model of the target is estimated based on the sequence of thermal images, the irradiance data indicative of the background temperature and the estimated emissivity of the target.

Abstract: The present disclosure is directed to irradiance sensing devices and methods. One such device includes a housing and an optical diffuser coupled to the housing. The housing has an opening that extends into the housing from an outer surface, and the opening has a circular shape at the outer surface of the housing. The optical diffuser has a first region that extends at least partially beyond the outer surface of the housing and a second region housed within the housing. The first region of the optical diffuser has a curved surface, and the optical diffuser includes a cavity extending at least partially into the second region.

Abstract: Implementations described herein relate to systems and methods to provide platform agnostic query acceleration. In some implementations, a method includes receiving, at a processor associated with a query acceleration service, a request from an client/application, wherein the request conforms to a particular wire protocol of a plurality of supported wire protocols, and wherein the request includes header data and body content data, analyzing the request to identify at least one of a query and a command in the body content data, determining an optimal matched model of the one or more query acceleration models, rewriting the query based on the optimal matched model, transmitting the rewritten query to the query processing platform, receiving a response to the rewritten query or the query from the query processing platform, and transmitting the received response to the application, wherein the transmission is configured based on the particular wire protocol.

Abstract: A pizza cheese composition may include a dairy cheese and analogue cheese. The dairy cheese can provide at least 10 weight percent of the pizza cheese composition. The analogue cheese may include one or more fats, casein protein, guar gum, and one or more hydrocolloid other than guar gum. The fat can range from 15 to 35 weight of the analogue cheese and be obtained from a non-dairy source. The casein protein can be present in an amount less than 3 weight percent of the analogue cheese. The hydrocolloid other than guar gum may range from 10 to 25 weight percent of the analogue cheese. An example specifies that a ratio of a weight of guar gum divided by a weight of casein protein is at least 1.0. This can provide enhanced freeze/thaw stability notwithstanding the reduced levels of casein protein used in the composition.

Abstract: The present disclosure is directed to irradiance sensing devices and methods. One such device includes a housing and an optical diffuser coupled to the housing. The housing has an opening that extends into the housing from an outer surface, and the opening has a circular shape at the outer surface of the housing. The optical diffuser has a first region that extends at least partially beyond the outer surface of the housing and a second region housed within the housing. The first region of the optical diffuser has a curved surface, and the optical diffuser includes a cavity extending at least partially into the second region.

Abstract: An optical system in which an aggressively compact reflective front end is combined with beam splitting elements and refractive relay optics to allow several imaging systems working in widely different wavelength bands to share a common aperture. The aggressively compact design results in significant field curvature at the uncorrected intermediate or virtual focus, which is corrected in the refractive relay optics for each band's imaging path.

Abstract: An optical system in which an aggressively compact reflective front end is combined with beam splitting elements and refractive relay optics to allow several imaging systems working in widely different wavelength bands to share a common aperture. The aggressively compact design results in significant field curvature at the uncorrected intermediate or virtual focus, which is corrected in the refractive relay optics for each band's imaging path.

Abstract: A method, apparatus, and article of manufacture provide the ability to store user defined scenarios in a three-dimensional system. A 3D view of a real world scene is displayed, using a three-dimensional (3D) graphics application. Plug-ins are installed into the 3D graphics application. A user selects a subset of the plug-ins, defines settings for the subset of plug-ins, and defines a visualization trait for each plug-in in the subset. The user associates an identification of the selected subset, the settings, and the visualization trait with a scenario bookmark that is saved. The bookmark can be selected by a user to display a visualization of a scenario based on the selected subset, settings, and visualization trait.

Abstract: A method, apparatus, and article of manufacture provide the ability to store user defined scenarios in a three-dimensional system. A 3D view of a real world scene is displayed, using a three-dimensional (3D) graphics application. Plug-ins are installed into the 3D graphics application. A user selects a subset of the plug-ins, defines settings for the subset of plug-ins, and defines a visualization trait for each plug-in in the subset. The user associates an identification of the selected subset, the settings, and the visualization trait with a scenario bookmark that is saved. The bookmark can be selected by a user to display a visualization of a scenario based on the selected subset, settings, and visualization trait.