Patents by Inventor Matthew Lebar

Matthew Lebar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10864266
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: December 15, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Publication number: 20200121786
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Application
    Filed: November 21, 2019
    Publication date: April 23, 2020
    Applicants: The Trustees of Princeton University, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Patent number: 10525126
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: January 7, 2020
    Assignees: THE TRUSTEES OF PRINCETON UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Patent number: 10358405
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: July 23, 2019
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Publication number: 20190218165
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 18, 2019
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Patent number: 10287227
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: May 14, 2019
    Assignees: UNIVERSITY OF SOUTH FLORIDA, The Department of Veterans Affairs
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Publication number: 20180265442
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau.
    Type: Application
    Filed: May 30, 2018
    Publication date: September 20, 2018
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Publication number: 20180037529
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Application
    Filed: January 24, 2017
    Publication date: February 8, 2018
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Publication number: 20170239350
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 24, 2017
    Applicant: The Trustees of Princeton University
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Patent number: 9677052
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: June 13, 2017
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Patent number: 9598338
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 21, 2017
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker, Matthew Lebar
  • Patent number: 9206103
    Abstract: The subject invention provides a myricanol compound that is in predominant form of (+)-?R,11S-myricanol as compared to (?)-?S,11R-myricanol. In one embodiment, the (+)-?R,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (?)-?S,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks of Myrica species. Also provided are methods for preparing extracts of the subject invention from Myrica species.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: December 8, 2015
    Assignee: University of South Florida
    Inventors: Chad Dickey, Matthew Lebar, Bill J. Baker, Jeffrey Jones
  • Publication number: 20150072029
    Abstract: The subject invention provides a myricanol compound that is in predominant form of (+)-?R,11S-myricanol as compared to (?)-?S,11R-myricanol. In one embodiment, the (+)-?R,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (?)-?S,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks of Myrica species. Also provided are methods for preparing extracts of the subject invention from Myrica species.
    Type: Application
    Filed: September 15, 2014
    Publication date: March 12, 2015
    Inventors: Chad DICKEY, Matthew LEBAR, Bill J. BAKER, Jeffrey JONES
  • Patent number: 8940945
    Abstract: The subject invention provides a myricanol compound that is in predominant form of (+)-?R,11S-myricanol as compared to (?)-?S,11R-myricanol. In one embodiment, the (+)-?R,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (?)-?S,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks of Myrica species. Also provided are methods for preparing extracts of the subject invention from Myrica species.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: January 27, 2015
    Assignee: University of South Florida
    Inventors: Chad Dickey, Matthew Lebar, Bill J. Baker, Jeffrey Jones
  • Publication number: 20130184353
    Abstract: The subject invention provides a myricanol compound that is in predominant form of (+)-?R,11S-myricanol as compared to (?)-?S,11R-myricanol. In one embodiment, the (+)-?R,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (?)-?S,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks of Myrica species. Also provided are methods for preparing extracts of the subject invention from Myrica species.
    Type: Application
    Filed: July 25, 2011
    Publication date: July 18, 2013
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Chad Dickey, Matthew Lebar, Bill J. Baker, Jeffrey Jones
  • Patent number: 5106048
    Abstract: A support stand including three upright, cylindrical lower support legs, each leg having a foot extending perpendicularly of the lower end of the leg. The stand further includes two vertically spaced connecting blocks having aligned linearly arranged apertures for receiving the legs, with the upper block mounted over the upper ends of the legs. The two outer legs are rotatably mounted in the blocks to permit the outer legs to be rotated to move the respective feet between a storage position, with the feet substantially aligned and extending perpendicularly of the blocks, and the support position with the feet splayed apart. An upright, cylindrical upper support leg is provided for mounting a support for a book, or piece of equipment such as a microphone and is telescopicaly received within the center leg.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: April 21, 1992
    Inventors: Matthew Lebar, Martin Lebar