Patents by Inventor Matthew Leung
Matthew Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12256761Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.Type: GrantFiled: February 12, 2024Date of Patent: March 25, 2025Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Michelle Warner, Ryan Edward Vanderpol, Thomas Pei-Ja Hsiu, Kathleen Carswell
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Patent number: 12252681Abstract: Disclosed herein are systems, devices, and methods for sterilization. In some variations, a method of sterilizing a bioreactor system may comprise circulating a sterilant in a bioreactor and an enclosed vessel in fluidic communication with the bioreactor. The enclosed vessel may comprise cell culture media. The sterilant may be circulated for a dwell time sufficient to sterilize at least one of the bioreactor, the vessel, and the cell culture media.Type: GrantFiled: August 18, 2020Date of Patent: March 18, 2025Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Patricia Rae Benton, Cameron Gentry Copeland, Stephen K. Hsu, Kalle Lukyan Johnson
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Publication number: 20240327767Abstract: This disclosure describes methods for growing cells in a controlled environment in a growing room, transporting the cells to a harvest room, and removing the cells from the controlled environment in the harvest room. The disclosed method can limit exposure of cells to contaminants by maintaining a controlled environment through cell growth and additional processing. For instance, the cells may be washed and cooled within the controlled environment. The cells are transferred to a harvest room where they are harvested and removed from the controlled environment.Type: ApplicationFiled: June 12, 2024Publication date: October 3, 2024Inventors: Matthew Leung, Konrad Müller-Auffermann
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Patent number: 12037569Abstract: This disclosure describes methods for growing cells in a controlled environment in a growing room, transporting the cells to a harvest room, and removing the cells from the controlled environment in the harvest room. The disclosed method can limit exposure of cells to contaminants by maintaining a controlled environment through cell growth and additional processing. For instance, the cells may be washed and cooled within the controlled environment. The cells are transferred to a harvest room where they are harvested and removed from the controlled environment.Type: GrantFiled: December 22, 2023Date of Patent: July 16, 2024Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Konrad Müller-Auffermann
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Publication number: 20240196944Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.Type: ApplicationFiled: February 12, 2024Publication date: June 20, 2024Inventors: Matthew Leung, Michelle Warner, Ryan Edward Vanderpol, Thomas Pei-Ja Hsiu, Kathleen Carswell
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Publication number: 20240124814Abstract: This disclosure describes methods for growing cells in a controlled environment in a growing room, transporting the cells to a harvest room, and removing the cells from the controlled environment in the harvest room. The disclosed method can limit exposure of cells to contaminants by maintaining a controlled environment through cell growth and additional processing. For instance, the cells may be washed and cooled within the controlled environment. The cells are transferred to a harvest room where they are harvested and removed from the controlled environment.Type: ApplicationFiled: December 22, 2023Publication date: April 18, 2024Inventors: Matthew Leung, Konrad Müller-Auffermann
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Patent number: 11898127Abstract: This disclosure describes methods for growing cells in a controlled environment in a growing room, transporting the cells to a harvest room, and removing the cells from the controlled environment in the harvest room. The disclosed method can limit exposure of cells to contaminants by maintaining a controlled environment through cell growth and additional processing. For instance, the cells may be washed and cooled within the controlled environment. The cells are transferred to a harvest room where they are harvested and removed from the controlled environment.Type: GrantFiled: September 26, 2022Date of Patent: February 13, 2024Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Konrad Müller-Auffermann
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Patent number: 11752509Abstract: An assembly for delivering a fluid includes a fluid dispenser connected to a fluid supply conduit. The fluid dispenser includes a fluid outlet positioned along a length of the fluid dispenser. The fluid outlet is configured to deliver the fluid from the fluid supply conduit at a flow rate that varies along the length of the fluid dispenser.Type: GrantFiled: June 17, 2021Date of Patent: September 12, 2023Assignee: Upside Foods, Inc.Inventors: Ryan Liu, Michelle Warner, Jaewon Samuel Kang, Matthew Leung, Eric Ordonez, Roshan Patel, Konrad Muller-Auffermann
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Patent number: 11752510Abstract: An assembly for delivering a fluid includes a fluid dispenser connected to a fluid supply conduit. The fluid dispenser includes a fluid outlet positioned along a length of the fluid dispenser. The fluid outlet is configured to deliver the fluid from the fluid supply conduit at a flow rate that varies along the length of the fluid dispenser.Type: GrantFiled: January 10, 2022Date of Patent: September 12, 2023Assignee: Upside Foods, Inc.Inventors: Ryan Liu, Michelle Warner, Jaewon Samuel Kang, Matthew Leung, Eric Ordonez, Roshan Patel, Konrad Muller-Auffermann
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Publication number: 20230203420Abstract: This disclosure relates to methods of growing cells within a hydrogel scaffold and pressurizing the hydrogel and cells to induce the cells to stretch and differentiation. The disclosed method can include coating a substrate of a bioreactor with a hydrogel and seeding cells onto the hydrogel and/or the substrate. The disclosed method can further include growing the seeded cells into a cell mass and pressurizing the cell mass and the hydrogel within the bioreactor. Pressurizing the cell mass and the hydrogel induces the cell mass and hydrogel to mechanically stretch, thereby inducing hypertrophy and cell alignment.Type: ApplicationFiled: October 27, 2022Publication date: June 29, 2023Inventors: Matthew Leung, Morgan Laurence Rease, David Kim, Jeanne Li, Emily Quan
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Publication number: 20230203446Abstract: This disclosure relates to methods of washing cells from a grown cell mass to remove cell culture media and enriching the cells with a finishing media. The disclosed method includes growing a cell mass in cell culture media and then collecting and washing the grown cell mass with a series of wash buffers or a gradient wash buffer that changes over time. While the cell culture media contains nutrients and components beneficial for cell growth, cells grown in cell culture media often have off flavors, off aromas, poor color, poor salt/minerality compositions, and other shortcomings. Accordingly, the disclosed method comprises removing cell culture media remnants from a grown cell mass using a single or a series of wash media. The grown cell mass is further washed with a finishing or enrichment buffer to further improve sensory aspects and nutritional composition of the grown cell mass.Type: ApplicationFiled: December 27, 2022Publication date: June 29, 2023Inventors: Konrad Müller-Auffermann, Stephen K. Hsu, Kalle Lukyan Johnson, Matthew Leung, Jayanthi Lakkyreddy, Morgan Laurence Rease, Jessica Joslin
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Patent number: 11627751Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.Type: GrantFiled: July 13, 2022Date of Patent: April 18, 2023Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Michelle Warner, Ryan Edward Vanderpol, Thomas Pei-Ja Hsiu, Kathleen Carswell
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Publication number: 20230091040Abstract: The substrates, systems, and methods described herein relate to textured substrates for preparing a comestible meat product. Substrates and methods are described herein for controlling one or more of growth, adhesion, retention, and/or release of cells (e.g., of a cell sheet) on or from the surface of the substrate. A method of preparing a comestible meat product may include applying a plurality of non-human cells to at least one patterned texture substrate, growing the cells on the patterned texture substrate to form the comestible meat product, and separating the comestible meat product from the patterned texture substrate. The patterned texture allows for improved growth, adhesion, retention, and/or release of cells as compared to another surface not comprising the patterned texture. In some embodiments, the cell culture substrate surfaces include a plurality of regions corresponding to a plurality of patterned textures.Type: ApplicationFiled: November 30, 2022Publication date: March 23, 2023Inventors: Matthew LEUNG, Asha GODBOLE, George C. ENGELMAYR, JR., Nicholas J. GENOVESE, Uma S. VALETI, Kathleen CARSWELL
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Patent number: 11576411Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.Type: GrantFiled: September 8, 2021Date of Patent: February 14, 2023Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Michelle Warner, Ryan Edward Vanderpol, Thomas Pei-Ja Hsiu, Kathleen Carswell
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Patent number: 11559072Abstract: The substrates, systems, and methods described herein relate to textured substrates for preparing a comestible meat product. Substrates and methods are described herein for controlling one or more of growth, adhesion, retention, and/or release of cells (e.g., of a cell sheet) on or from the surface of the substrate. A method of preparing a comestible meat product may include applying a plurality of non-human cells to at least one patterned texture substrate, growing the cells on the patterned texture substrate to form the comestible meat product, and separating the comestible meat product from the patterned texture substrate. The patterned texture allows for improved growth, adhesion, retention, and/or release of cells as compared to another surface not comprising the patterned texture. In some embodiments, the cell culture substrate surfaces include a plurality of regions corresponding to a plurality of patterned textures.Type: GrantFiled: April 21, 2022Date of Patent: January 24, 2023Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Asha Godbole, George C Engelmayr, Jr., Nicholas J Genovese, Uma S Valeti, Kathleen Carswell
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Patent number: 11559073Abstract: The substrates, systems, and methods described herein relate to textured substrates for preparing a comestible meat product. Substrates and methods are described herein for controlling one or more of growth, adhesion, retention, and/or release of cells (e.g., of a cell sheet) on or from the surface of the substrate. A method of preparing a comestible meat product may include applying a plurality of non-human cells to at least one patterned texture substrate, growing the cells on the patterned texture substrate to form the comestible meat product, and separating the comestible meat product from the patterned texture substrate. The patterned texture allows for improved growth, adhesion, retention, and/or release of cells as compared to another surface not comprising the patterned texture. In some embodiments, the cell culture substrate surfaces include a plurality of regions corresponding to a plurality of patterned textures.Type: GrantFiled: April 21, 2022Date of Patent: January 24, 2023Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Asha Godbole, George C Engelmayr, Jr., Nicholas J Genovese, Uma S Valeti, Kathleen Carswell
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Publication number: 20220401974Abstract: An assembly for delivering a fluid includes a fluid dispenser connected to a fluid supply conduit. The fluid dispenser includes a fluid outlet positioned along a length of the fluid dispenser. The fluid outlet is configured to deliver the fluid from the fluid supply conduit at a flow rate that varies along the length of the fluid dispenser.Type: ApplicationFiled: January 10, 2022Publication date: December 22, 2022Applicant: Upside Foods, Inc.Inventors: Ryan LIU, Michelle WARNER, Jaewon Samuel KANG, Matthew LEUNG, Eric ORDONEZ, Roshan PATEL, Konrad MULLER-AUFFERMANN
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Publication number: 20220401973Abstract: An assembly for delivering a fluid includes a fluid dispenser connected to a fluid supply conduit. The fluid dispenser includes a fluid outlet positioned along a length of the fluid dispenser. The fluid outlet is configured to deliver the fluid from the fluid supply conduit at a flow rate that varies along the length of the fluid dispenser.Type: ApplicationFiled: June 17, 2021Publication date: December 22, 2022Applicant: Upside Foods, Inc.Inventors: Ryan LIU, Michelle WARNER, Jaewon Samuel KANG, Matthew LEUNG, Eric ORDONEZ, Roshan PATEL, Konrad MULLER-AUFFERMANN
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Publication number: 20220361538Abstract: The apparatuses described herein relate to preparation of a meat product. Apparatuses, systems comprising the apparatuses, and methods of making and use the systems and apparatuses are described herein. These are useful for controlling one or more of growth on and separation of a meat product from an enclosed substrate. The apparatuses and systems are configured to receive fluid and grow the meat product and/or separate the meat product from the substrate in a scalable manner.Type: ApplicationFiled: July 13, 2022Publication date: November 17, 2022Inventors: Matthew LEUNG, Michelle WARNER, Ryan Edward VANDERPOL, Thomas Pei-Ja HSIU, Kathleen CARSWELL
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Publication number: 20220248727Abstract: The substrates, systems, and methods described herein relate to textured substrates for preparing a comestible meat product. Substrates and methods are described herein for controlling one or more of growth, adhesion, retention, and/or release of cells (e.g., of a cell sheet) on or from the surface of the substrate. A method of preparing a comestible meat product may include applying a plurality of non-human cells to at least one patterned texture substrate, growing the cells on the patterned texture substrate to form the comestible meat product, and separating the comestible meat product from the patterned texture substrate. The patterned texture allows for improved growth, adhesion, retention, and/or release of cells as compared to another surface not comprising the patterned texture. In some embodiments, the cell culture substrate surfaces include a plurality of regions corresponding to a plurality of patterned textures.Type: ApplicationFiled: April 21, 2022Publication date: August 11, 2022Inventors: Matthew LEUNG, Asha GODBOLE, George C ENGELMAYR, JR., Nicholas J GENOVESE, Uma S VALETI, Kathleen CARSWELL