Abstract: Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae and in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

Abstract: Implementations described herein relate to training and refining robotic control policies using imitation learning techniques. A robotic control policy can be initially trained based on human demonstrations of various robotic tasks. Further, the robotic control policy can be refined based on human interventions while a robot is performing a robotic task. In some implementations, the robotic control policy may determine whether the robot will fail in performance of the robotic task, and prompt a human to intervene in performance of the robotic task. In additional or alternative implementations, a representation of the sequence of actions can be visually rendered for presentation to the human can proactively intervene in performance of the robotic task.

Abstract: A system and method for controlling a vehicle platform, the system comprising on onboard controller and an off-board controller that work together to provide autonomous navigation in fields or similar areas where the vehicle is deployed, perception for obstacle detection and avoidance, and a user interface for user/vehicle interaction and control.

Abstract: A method for determining an identity of an individual is provided. The method can include receiving a first unique identifier from a first device associated with a first individual. The method can also include receiving biometric data associated with the first individual. The method can further include determining an identity of the first individual by filtering a database to generate a set of candidate identities. The database can include associations of a registered identity, a registered unique identifier, and registered biometric data for each of a plurality of individuals. Determining the identity of the first individual can also include comparing the received biometric data to registered biometric data in the database of at least one candidate identity, and selecting the identity from the set of candidate identities. The method can also include providing the identity. Related systems, apparatuses, and computer-readable mediums are also provided.

Abstract: A system and method for controlling a vehicle platform, the system comprising on onboard controller and an off-board controller that work together to provide autonomous navigation in fields or similar areas where the vehicle is deployed, perception for obstacle detection and avoidance, and a user interface for user/vehicle interaction and control.

Abstract: Described herein is a system a method and composition for manufacturing shelf-stabilized chlorophyll in beverage form. The chlorophyll beverage may be produced on a commercial or larger scale. The chlorophyll beverage may be formed of chlorophyllin and water, as well as a shelf-stabilization agent, with no refrigeration required.

Abstract: Methods and apparatus for inking a surgical instrument are provided herein. In some embodiments, and apparatus for inking a surgical instrument includes: an inking capsule, comprising a base and a vertical wall extending from the base to define a cavity, the inking capsule having a first opening opposite the base; an ink reservoir disposed within the cavity, the ink reservoir having ink disposed therein and comprising a second opening proximate a top portion of the ink reservoir, and a penetrable seal covering the second opening to seal the ink in the ink reservoir when the seal is in an unbroken state.

Abstract: An apparatus for inking a surgical instrument includes an inking capsule, which comprises a base and a vertical wall extending from the base to define a cavity. The inking capsule has a first opening opposite the base, an ink reservoir disposed within the cavity, where the ink reservoir has ink disposed therein. The ink reservoir comprises a second opening proximate a top portion of the ink reservoir, and a penetrable seal covering the second opening to seal the ink in the ink reservoir when the seal is in an unbroken state.

Abstract: A system for generating and providing an inline resharing interface and sharing content includes a processor and a memory storing instructions that, when executed, cause the system to provide items of content for presentation; receive input identifying a selected item from the items of content; generate an inline sharing interface corresponding to the selected item, the inline sharing interface including a portion of original content from the selected item, an comment area, and an addressee area; and provide the inline sharing interface for presentation in place of the selected item.

Abstract: Methods and apparatus for inking a surgical instrument are provided herein. In some embodiments, and apparatus for inking a surgical instrument includes: an inking capsule, comprising a base and a vertical wall extending from the base to define a cavity, the inking capsule having a first opening opposite the base; an ink reservoir disposed within the cavity, the ink reservoir having ink disposed therein and comprising a second opening proximate a top portion of the ink reservoir; and a penetrable seal covering the second opening to seal the ink in the ink reservoir when the seal is in an unbroken state.

Abstract: A method for Internet delivery in a delivery network established at network locations, the delivery network comprising a plurality of content servers for serving resources. The servers include a plurality of subsets, each subset being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of data centers to be used to service the requests. For the IP address block, the method selects at least one of the data centers from the candidate list. The selected Internet data center for the IP address block is written into a network map. In response to a DNS query, the map is used to identify one of the Internet data centers from the candidate list to be used to service a request for a content resource.

Abstract: A system and/or process for scheduling patients in a medical practice may be adapted to achieve a set of predetermined scheduling goals of the practice. Such a system may involve collecting a set of scoring parameters for scoring a patient and assigning a numerical quantity to each scoring parameter according to a set of predetermined scoring rules. A patient score may be calculated as an average of the scoring parameters. A set of patient score ranges may be defined to categorize patients into a set of classes (i.e. patient buckets) based on their score. Time ranges may be defined relative to the present time (i.e. time of scheduling) wherein each range is associated with a set of scheduling rules governing the allowed ratio of patients from each patient bucket. A patient may be assigned to a given appointment time slot provided that no scheduling rules are violated thereby.

Abstract: The invention relates to an apparatus for responding to data requests made by a client. The apparatus includes an input receiving a first data request that includes a sequence of nodes corresponding to a sequence of servers. The apparatus also includes decision logic determining whether the data specified in the data request is available on a selected server, and if the data is not available determining a next node from the sequence of nodes. The apparatus also includes a mapper mapping a server to the next node, and an output requesting the data by transmitting a second data request to the server mapped to the next node.

Abstract: A method for Internet content delivery in a content delivery network established at network locations, the content delivery network comprising a plurality of content servers for serving content resources. The plurality of content servers includes a plurality of subsets of content servers, each subject being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of Internet data centers to be used to service the requests for content resources. For the IP address block, the method selects at least one of the Internet data centers from the candidate list to be used to service the requests for content resources. The selected Internet data center for the IP address block is written into a network map.

Abstract: The invention relates to an apparatus for responding to data requests made by a client. The apparatus includes an input receiving a first data request that includes a sequence of nodes corresponding to a sequence of servers. The apparatus also includes decision logic determining whether the data specified in the data request is available on a selected server, and if the data is not available determining a next node from the sequence of nodes. The apparatus also includes a mapper mapping a server to the next node, and an output requesting the data by transmitting a second data request to the server mapped to the next node.

Abstract: The invention relates to a method and apparatus for distributing a request to one of a plurality of resources. A request is mapped to a location in circular mapping space using a hash function. Each of the plurality of resources is mapped to a respective location or locations in the circular mapping space. The request is allocated to one of the resources based on the given request location and the resource location in the circular mapping space.

Abstract: An intelligent traffic redirection system that performs global load balancing can be used in any situation where an end-user requires access to a replicated resource. The method directs end-users to the appropriate replica so that the route to the replica is good from a network standpoint and the replica is not overloaded. The technique preferably uses a Domain Name Service (DNS) to provide IP addresses for the appropriate replica. The most common use is to direct traffic to a mirrored web site.