Abstract: An LED lamp and method are provided for autonomously changing the output brightness and color temperature of a plurality of LED strings to follow a first dimcurve in temporal synchronization with at least one other LED lamp. Synchronization is achieved based on a time of day determined using a clock signal. The output brightness and color temperature can transition from the first dimcurve to a second dimcurve over a predetermined number of scenes. The number of scenes is a function of a difference between the first dimcurve and the second dimcurve in at least one of the output brightness and the color temperature.

Abstract: There is provided an electronically controlled, motor-driven, breath actuated metered dose inhaler for delivering aerosolized medicament or other matter to a user. The inhaler may comprise a base housing including a motor-driven actuator and other system components and a removable aerosol cartridge insertably receivable in the base housing. The inhaler may be paired with a smart phone or other client computing device to provide additional functionality, such as to provide instructional information and feedback regarding usage of the inhaler, to generate and display dosage tracking information, and to provide alerts and reminders to a user of the inhaler or others.

Abstract: The disclosure relates generally to analytical measurement and, more specifically, to the use of ion spectrometry, including mass analysis, for the quantitation and chemical characterization (e.g., identification) of biological or synthetic materials using two different ion spectrometric measurement cycles. The methods may be employed fruitfully in particular with analyte molecules of low molecular weight, such as metabolites.

Abstract: The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).

Abstract: A contact element of a MEMS relay. The contact element includes a defined number greater than one of electrically conductive contact bodies, wherein the contact bodies are arranged at least partially within a layer that is plastically deformable in a defined manner, wherein a hardness of the plastically deformable layer is less than a hardness of the contact bodies, wherein, by exerting a compressive force on the contact bodies, the contact bodies can be pressed into the plastically deformable layer and brought to a substantially uniform height level, and wherein the plastically deformable layer is arranged at least partially within an insulation layer.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A connector assembly includes a base and a detachable cover. Ports on separate sidewalls receive an extension cable and a lead. A blade assembly maintains electrical contact between the cable and the lead, while providing a surface to strip insulation and/or sever the lead. Further, the blade is resilient so as to maintain sufficient contact with the lead when the cover is attached and/or locked to the base.

Abstract: A vehicle battery jump starter with air pump device includes a vehicle battery jump starter and an air pump disposed within a cover. An internal battery is also disposed within the cover and connected to the vehicle battery jump starter and the air pump. A port is provided so as to provide connection to the device from an external vehicle battery. The air pump is configured such that it is powered by the external battery in a first mode of operation.

Abstract: The present disclosure provides therapeutic agents e.g., hygromycin A for use in the treatment, prevention, or management of diseases. The diseases can be caused by microbes of Fusobacterium or Treponema spp. The therapeutic agents of the disclosure can be used to inhibit the growth of the microbes described herein.

Abstract: A dispenser for dispensing a selected volume of water at a specified temperature. The dispenser includes a source of water at an elevated temperature and a source of water at a lower temperature. An electronic controller determines the volume of water needed from each source in order to arrive at the selected volume and temperature. The dispenser uses a recirculation valve to circulate at least the elevated temperature water in the tank and in the outlet in order to ensure the temperature of the water is as expected throughout the system to achieve the specified temperature.

Abstract: A personal watercraft is disclosed including a flotation portion, a strut extending from the flotation portion, and a motor pod is disposed along the strut with an electric motor operably coupled to a driveshaft. A hydrojet unit is removably attached to the motor pod and includes an inlet portion removably attached to the motor pod and a substantially cylindrical housing. The inlet portion includes a substantially conical motor interface with a shaft through-hole for receiving the driveshaft therein, one or more fins extending outwardly from the conical motor interface, and at least one ring encircling the conical motor interface and connecting to each of the one or more fins for inhibiting objects from passing through the inlet region. The housing defines a fluid flow path to an outlet portion. The hydrojet unit includes an impeller coupled to the driveshaft and a stator disposed within the housing.

Abstract: A portable, self-contained beverage apparatus includes a container assembly having a known storage capacity for storing a consumable liquid, and a dispensing assembly disposed within the container assembly that dispenses variable, non-zero quantities of additives into the consumable liquid. The dispensing assembly includes multiple apertures structured and arranged to retain vessels containing the additives to be dispensed into the consumable liquid. The beverage apparatus also includes a level sensor disposed within the container assembly that determines a consumable liquid level of the consumable liquid stored in the container assembly. In certain embodiments, one or more positive displacement pumping mechanisms are configured to pump additive liquid from additive containers into a beverage chamber.

Abstract: Systems and methods are provided for providing energy consumption feedback for powering a transport climate control system using external data. This can include determining whether an energy level of an energy storage source is greater than an expected energy consumption of a transport climate control system during a route, based on route parameters and route conditions. The route conditions may be obtained from a source such as a remote server, and include data such as weather data, traffic data, or the like. The systems and methods may further compare current energy levels to an updated predictions of energy consumption during transit to determine if the energy level is sufficient to complete the route and alert the user when the energy level is insufficient to complete the route.

Abstract: Described herein is a method for managing media item playback. A method includes presenting a media player playing a media item in a first portion of a user interface (UI) provided by a first application on a screen of a user device, responsive to a first user input, reducing a size of the media player playing the media item to allow a user to open a second mobile application, causing playback of the media item to be continued in the media player of the reduced size while content associated with the second application is being presented to the user on the screen of the user device, and responsive to a second user input, restoring the size of the media player while the media player continues to play the media item.

Abstract: A method at a computing device for providing vehicle data to a client, the method including receiving a data object at an ingestor block at the computing device, the ingestor block comprising a plurality of ingestor instances capable of interacting with different entities; converting the data object to a frame; providing the frame to a translation stack at the computing device to convert the frame into a normalized message; and providing the normalized message to the client.

Abstract: A cloud-based system and method for securely storing data formed into cloud technology-specific data objects (hereinafter, “buckets”) by an S3 gateway, comprising obtaining a source data bucket from the S3 gateway; splitting the data bucket into at least three fragments; encrypting the fragments using an encryption key associated with the fragments and distributing the encrypted fragments among at least three cloud storage providers, and creating a pointer file containing information for retrieving the encrypted fragments. When a system user requests access to the data, the system ensures the request is legitimate, then uses the information stored in the pointer file to retrieve the stored encrypted bucket fragments from the plurality of clouds, decrypts the fragments and reconstructs the data buckets, and provides data access to the S3 gateway.

Abstract: Systems and methods are provided for providing predictive energy consumption feedback for powering a transport climate control system. This can include determining whether an energy level of an energy storage source is greater than an expected energy consumption of a transport climate control system during a route, based on route parameters. The route parameters may be obtained via a human-machine interface. When the energy storage source is less than the expected energy consumption, a user is alerted. The systems and methods may further compare the energy level to an expected energy level during transit to determine if the energy level is greater or less than expected and alert the user when the energy level is less than expected.

Abstract: Methods and devices for handling a fluid and delivering the fluid to the eye. The device has a vibrating element with a plurality of openings through which a fluid is ejected when the vibrated. An enclosure defines a chamber which holds a single application of the fluid. The enclosure may be biased against the vibrating element with a spring load developed in whole or part by the resilient structure of the enclosure. The chamber may be substantially empty after the single application.

Abstract: A method for notifying and mitigating a suboptimal event occurring in a transport climate control system that provides climate control to a climate controlled space of a transport unit is provided. The method includes monitoring an amount of power available for powering the transport climate control system, monitoring a power demand from the transport climate control system, and accessing operational data of the transport climate control system and the transport unit. The method also includes a controller determining whether a suboptimal event is detected based on one or more of the monitored amount of power available, the monitored power demand and the accessed operational data. Also, the method includes the controller generating a notification when a suboptimal event is detected, and the controller instructing the generated notification to be displayed on a display.

Abstract: A vehicle battery jump starter with air pump device includes a vehicle battery jump starter and an air pump disposed within a cover. An internal battery is also disposed within the cover and connected to the vehicle battery jump starter and the air pump. A port is provided so as to provide connection to the device from an external vehicle battery. The air pump is configured such that it is powered by the external battery in a first mode of operation.