Abstract: Examples described herein relate to management of concurrent audio streams from different sources. Portable playback devices, such as wearable wireless headphones and earbuds, as well as portable battery-powered speakers, may include multiple network interfaces for connection to different types of networks, such as an 802.11-compatible network interface for connection to wireless local area networks (e.g., Wi-Fi® networks) and an 802.15-compatible network interface for connection to a mobile device via a personal area network (Bluetooth®). Via such connections, the playback devices may receive two or more concurrent streams. By managing these streams according to playback policies, the portable playback devices may play the user's intended audio without necessarily requiring user input to explicitly select among the concurrent streams.

Abstract: Transparently providing a virtualization feature to an unenlightened guest operating system (OS). A guest partition, corresponding to a virtual machine, is divided into a first guest privilege context and a second guest privilege context. A compatibility component executes within the first guest privilege context, while a guest OS executes within the second guest privilege context. The compatibility component is configured to intercept input/output (I/O) operations associated with the guest operating OS. Based on the compatibility component intercepting an I/O operation associated with the guest OS, the compatibility component processes the I/O operation using a virtualization feature that is unsupported by the guest OS. Examples of the virtualization feature include accelerated access to a hardware device and virtual machine guest confidentiality.

Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: Aspects of the present disclosure include a method for sorting cells of a sample based on an image of a cell in a flow stream. Methods according to certain embodiments include detecting light from a sample having cells in a flow stream, generating an image mask of a cell from the sample and sorting the cell based on the generated image mask. Systems having a processor with memory operably coupled to the processor having instructions stored thereon, which when executed by the processor, cause the processor to generate an image mask of a cell in a sample in a flow stream and to sort the cell based on the generated image mask are also described. Integrated circuit devices (e.g., field programmable gate arrays) having programming for generating an image mask and for determining one or more features of the cell are also provided.

Abstract: The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1 or Compound No. 2: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: Data-at-rest protection for virtual machines includes operating a data protection component within a first privilege context of a guest partition, and operating a guest operating system (OS) within a second privilege context of the guest partition. The data protection component participates in data input/output operations of the guest OS. Based on a data output operation of the guest OS, the data protection component applies a first data protection operation to first data associated with the data output operation; and initiates storage of a first result of the first data protection operation to a data storage device. Based a data input operation of the guest OS, the data protection component applies a second data protection operation to second data associated with the data input operation; and, based on applying the second data protection operation to the second data, communicates an outcome of the data input operation to the guest OS.

Abstract: In one embodiment, an articulable endoscopic instrument including an articulable retractor configured to pass through a working channel of an endoscope, the articulable retractor including an end effector mounted to a distal end of the articulable retractor, and a handle to which the articulable retractor is mounted, the handle comprising controls that enable a user of the instrument to both articulate the retractor and actuate the end effector, wherein the retractor can be articulated using the controls to form two independent bends lying within one plane, the bends together forming a complex curve.

Abstract: A latch assembly 1 and a latch set 1, 2, 3, 4 for use with a sliding door frame 6. The latch assembly 1 includes a housing 48, 49, and a bolt 17 pivotable relative to the housing 48, 49 on rotation of either one of a pair of actuator hubs 51, 52. The latch assembly 1 also includes a pair of locking hubs, 53, 54 which are also rotatable to adjust the lock mechanism between an active condition and an inactive condition.

Abstract: In one embodiment, an articulable endoscopic instrument including an articulable retractor configured to pass through a working channel of an endoscope, the articulable retractor including an end effector mounted to a distal end of the articulable retractor, and a handle to which the articulable retractor is mounted, the handle comprising controls that enable a user of the instrument to both articulate the retractor and actuate the end effector, wherein the retractor can be articulated using the controls to form two independent bends lying within one plane, the bends together forming a complex curve.

Abstract: This invention relates to a latch assembly 1, and a latch set 1, 2, 3, 4 for use with a sliding door frame 6. The latch assembly 1 includes a housing 48, 49, and a bolt 17 pivotable relative to the housing 48, 49 on rotation of either one of a pair of actuator hubs 51, 52. The latch assembly 1 also includes a pair of locking hubs, 55, 54 which are also rotatable to adjust the lock mechanism between an active condition and an inactive condition.