Abstract: A faucet-mounted filter system includes a body forming a fluid chamber having a water inlet, a quick connect device positioned adjacent the water inlet for mounting the filter system to a water faucet, a filtered water flow path disposed within the body and in fluid communication with the water inlet, an unfiltered water flow path disposed within the body and in fluid communication with the water inlet, a diverter valve disposed within the fluid chamber and operable to open and close the filtered and unfiltered water flow paths, a seal, an actuator engaging the diverter valve to open and close the filtered and unfiltered water flow paths, a flow meter connected to the body and in fluid communication with the filter flow path, a filter housing connected to the body and having a reservoir, and a filter cartridge disposed within the reservoir.

Abstract: An oral-care implement comprises a mounting surface having a longitudinal axis and a transverse axis perpendicular to the longitudinal axis and a plurality of filaments outwardly extending from the mounting surface in at least one direction not parallel to either one of the longitudinal axis and the transverse axis, each filament having a free end terminating with a tip. At least some of the filaments possess at least one functional characteristic selected from the group consisting of filament's structure, composition, cross-sectional shape, tip geometry, and any combination thereof. A plurality of filament tips comprises a working surface that includes at least a first color and a second color different from the first color.

Abstract: A tooth-whitening process includes providing an array of LEDs disposed in a first plane and forming an inner arc having an inner focal point and an outer arc having an outer focal different from the inner focal point; applying a whitening composition to at least the anterior surfaces of at least six mandibular or maxillary anterior teeth and maintaining the whitening composition on the at least six teeth for a first time period; after the first time period, directing a light radiation comprising blue visible light or near-visible UV light of at least a threshold intensity from the least a first array of LEDs for a second time period to the anterior surfaces of the at least six teeth, the first time period having a duration greater than 50% of a total duration of the first time period and the second time period; and removing the whitening composition from the at least six teeth.

Abstract: A portable self-contained tooth-whitening device includes a compact housing structured and configured to be held in a fixed position adjacent to a human jaw during use; at least a first array of LEDs disposed in a first plane at a front side of the housing and arranged to deliver blue visible light or near-visible UV light of at least a threshold intensity to substantially all anterior surfaces of anterior maxillary teeth or anterior mandibular teeth of the human jaw, wherein the first array of LEDs forms at least two intersecting arcs, each of which is disposed in the first plane and has its own focal point located outside the device; and at least one battery cell powering the array of LEDs.

Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: A class of polycyclic compounds of general formula (II), of general formula (II?), or of general formula (II?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: A portable self-contained tooth-whitening device includes a compact housing structured and configured to be held in a fixed position adjacent to a human jaw during use; at least a first array of LEDs disposed in a first plane at a front side of the housing and arranged to deliver blue visible light or near-visible UV light of at least a threshold intensity to substantially all anterior surfaces of anterior maxillary teeth or anterior mandibular teeth of the human jaw, wherein the first array of LEDs forms at least two intersecting arcs, each of which is disposed in the first plane and has its own focal point located outside the device; and at least one battery cell powering the array of LEDs.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: A joining machine to join work-pieces together comprises a body, at least one scanner disposed on the body and configured to collect data on the work-pieces and convert the data to a scanned image, a guide device and a positioning device. The positioning device is configured to determine a join position according to the scanned image and instruct the guide device to indicate the join position on the work-pieces to an operator of the machine.

Abstract: A thermal barrier panel, the panel having a top face overlying a monolithic core, the core comprising a mixture of expanded glass granules, ceramic microspheres and a calcium aluminate cement binder, the expanded glass granules are selected from the group consisting of small granules having a size of about 0.5 mm to 1.0 mm, intermediate granules having a size of about 1.10 mm to 2.00 mm, and large granules having a size of about 2.10 mm to 4.00 mm wherein the volume of intermediate size granules comprises more than 50% of the mixture of expanded glass granules and the balance comprises small and large granules in a ratio of 1:2. The invention is also directed to a shipping container fitted with the fire containment panels of the present invention.

Abstract: An apparatus for setting up a specialized personal electronic assistant on an electronic device includes a processor, a display, a language module, a tracking module, a knowledge module, and a rendering module. The language module interprets a communication from a user into a data request. The tracking module stores the data request as one of a plurality of stored data requests. The knowledge module determines a response to the data request. The rendering module displays the response in a tiled area on an image display of the electronic device.

Abstract: A feed system for an injection molding machine. The feed system includes a first part with a first channel, and a second part with a second channel. The first channel and the second channel together form a molten plastic feed conduit when they are engaged. The first part and the second part are unbonded to one another.

Abstract: A method may include storing, in a memory associated with a computer device, cached content associated with a document and receiving a request to access the document. The method may further include sending a request to revalidate the cached content to a server device associated with the document, performing speculative rendering of the document, using the cached content, the speculative rendering being performed as a plurality of work items, receiving revalidated content associated with the document, determining invalid ones of the plurality of work items based on the revalidated content, and discarding the invalid ones of the plurality of work items.

Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is —C(R1)= or —N?; and X is selected from the group consisting of: (II-i), (II-ii), (I) (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

Abstract: Methods for producing toothbrush handles having an inner cavity are provided.

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: A portable self-contained tooth-whitening device includes a compact housing structured and configured to be held in a fixed position adjacent to a human jaw during use; at least a first array of LEDs disposed in a first plane at a front side of the housing and arranged to deliver blue visible light or near-visible UV light of at least a threshold intensity to substantially all anterior surfaces of anterior maxillary teeth or anterior mandibular teeth of the human jaw, wherein the first array of LEDs forms at least two intersecting arcs, each of which is disposed in the first plane and has its own focal point located outside the device; and at least one battery cell powering the array of LEDs.

Abstract: A tooth-whitening process includes providing an array of LEDs disposed in a first plane and forming an inner arc having an inner focal point and an outer arc having an outer focal different from the inner focal point; applying a whitening composition to at least the anterior surfaces of at least six mandibular or maxillary anterior teeth and maintaining the whitening composition on the at least six teeth for a first time period; after the first time period, directing a light radiation comprising blue visible light or near-visible UV light of at least a threshold intensity from the least a first array of LEDs for a second time period to the anterior surfaces of the at least six teeth, the first time period having a duration greater than 50% of a total duration of the first time period and the second time period; and removing the whitening composition from the at least six teeth.