Abstract: The present disclosure provides nucleotide conjugates each configured to include a core attached to multiple nucleotide-arms, where the nucleotide-arms are modular and comprise (i) a core attachment moiety, (ii) a spacer, (iii) a linker, and (iv) a nucleotide unit. The nucleotide unit of each nucleotide-arm can bind a polymerase which is complexed with a nucleic acid template and nucleic acid primer. The nucleotide unit can bind the 3? end of the primer at a position that is opposite a complementary nucleotide in the template strand. Under suitable conditions, the nucleotide unit of the nucleotide conjugates binds the primer strand but does not undergo polymerase-catalyzed incorporation. The binding event can be detected, and the specific base of the nucleotide unit can be identified. The nucleotide conjugates described herein are useful for nucleic acid sequencing methods, particularly for massively parallel sequencing methods employed for next gen sequencing platforms.

Abstract: A module for initializing and calibrating a product during the manufacture of the product in a manufacturing environment, wherein the module is able to be arranged on the product and wherein the module has a first interface for wireless data transmission between the module and the manufacturing environment, a second interface for establishing a data connection between the module and the product, an electrical energy source and a data processing unit. The module is designed to supply the product at least temporarily with energy by way of the energy source, to establish a data connection with the product via the second interface, to perform test and/or calibration routines on the product via the second interface, wherein the data processing unit generates test and/or calibration data during the performance of the test and/or calibration routines, and to transmit the test and/or calibration data to the manufacturing environment via the first interface.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: The present invention relates to a preferably computer-implemented method of raising a group of monogastric animals Issues such as exposure of the animals to an initiator of a disease are recognized at an early stage by ex vivo analysis of blood samples. Said analysis is done where the animals are raised using point-of-care devices. Accuracy of separation between affected and non-affected animals is increased by measuring a set of pre-determined blood parameters. The landless monogastric animal production system of the invention facilitates implementation of the method of the invention.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: The present disclosure relates to systems and methods for an intelligent assistant (e.g., a chatbot) that can be used to enable a user to generate a machine learning system. Techniques can be used to automatically generate a machine learning system to assist a user. In some cases, the user may not be a software developer and may have little or no experience in either machine learning techniques or software programming. In some embodiments, a user can interact with an intelligent assistant. The interaction can be aural, textual, or through a graphical user interface. The chatbot can translate natural language inputs into a structural representation of a machine learning solution using an ontology. In this way, a user can work with artificial intelligence without being a data scientist to develop, train, refine, and compile machine learning models as stand-alone executable code.

Abstract: One or more antennas are electrically coupled to one or more switches of an implantable medical device (IMD) in which the one or more switches are additionally electrically coupled to one or more lead wires of an IMD lead. The one or more switches also are electrically coupled to one or more electrodes or electrical circuitry of the IMD's implantable pulse generator (IPG). In response to exposure of the IMD to an energetic electromagnetic field, a voltage signal is induced in the one or more antennas and provided, possibly via one more filters, as a control signal to the one or more switches. Receipt of the control signal by the one or more switches automatically configures the one or more switches into a non-conductive state, thereby electrically isolating the one or more lead wires from the one or more electrodes or the IPG electrical circuitry.

Abstract: One or more antennas are electrically coupled to one or more switches of an implantable medical device (IMD) in which the one or more switches are additionally electrically coupled to one or more lead wires of an IMD lead. The one or more switches also are electrically coupled to one or more electrodes or electrical circuitry of the IMD's implantable pulse generator (IPG). In response to exposure of the IMD to an energetic electromagnetic field, a voltage signal is induced in the one or more antennas and provided, possibly via one more filters, as a control signal to the one or more switches. Receipt of the control signal by the one or more switches automatically configures the one or more switches into a non-conductive state, thereby electrically isolating the one or more lead wires from the one or more electrodes or the IPG electrical circuitry.

Abstract: Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocation control element, and a second reporter code, wherein the ends of the reporter construct are attached to phosphoramidate-nucleoside. Related methods and products are also provided.

Abstract: Disclosed is a system for controlling a robot via a foot-operable controller. The foot-operable controller includes a grid of large pressure-sensitive tiles that are responsive to being stepped on. Signals from the pressure-sensitive tiles are provided to a controller interface that converts the signals to control messages compatible with existing robot control interfaces, such as a universal serial bus. The foot-operable controller may be used to control various robots, including for example a robot equipped with a claw arm or a robot equipped with a ring launcher.

Abstract: An optimization engine builds a set of test forms, called a pallet for use in a qualification test setting. The pallet is generated using a optimization engine programmed with constraints and goals for each test form in the pallet and for the pallet in general. A test information floor is set at the cut point of the test which causes test items to be focused at the area of the test where the pass/fail decision is made. Further constraints may be programmed to maximize the item diversity, that is, to spread the use of available test items as uniformly as possible.

Abstract: Technologies for enabling support providers to integrate into a support application and provide real-time support for requests based at least partly on authorizations associated with the support providers are described. The technologies described can access authentication data associated with support providers. The technologies described can receive a request associated with a product and/or a service and determine contextual data associated with the request. The technologies described can determine authorization data associated with support providers, determine support providers for supporting the request based partly on the contextual data, determine that the support providers are authorized to receive the request, and generate task data associated with the request.

Abstract: Technologies for enabling real-time support for requests (e.g., onboarding requests, support requests, managing requests, troubleshooting requests, etc.) based at least in part on contextual data are described. The technologies described can receive a request associated with a product and/or a service and determine contextual data associated with the request. The contextual data can define a status of an application associated with the product and/or the service. Additionally, the technologies described can include determining support providers for supporting the request based partly on the contextual data and generating task data associated with the request. The task data can include the contextual data.

Abstract: A test results screening tool allows capture of test item and test results data and provides a reviewer with a robust set of tools for entering screening criteria and display of test results by both test subject and test center. The tool includes parametrically sets flags for unwanted testing behaviors including test item harvesting, test subjects with pre-knowledge of the test subject matter, and proxy test takers for some a portion of a test.

Abstract: A golf club may include a control unit that detects a swing of the golf club and generates a signal based on at least one goal swing parameter during the swing of the golf club. The golf club may include a stimulation generation module, configured to generate a stimulation in response to the signal.

Abstract: A test results screening tool allows capture of test item and test results data and provides a reviewer with a robust set of tools for entering screening criteria and display of test results by both test subject and test center. The tool includes parametrically sets flags for unwanted testing behaviors including test item harvesting, test subjects with pre-knowledge of the test subject matter, and proxy test takers for some a portion of a test.

Abstract: A method of calibrating a printing apparatus comprising: providing a printing apparatus with a mobile printhead, the printhead being mobile along a scanning direction, the printhead comprising a plurality of nozzles; providing a media; printing a first pattern on the media while scanning the media with the printhead at a first scanning velocity; printing a second pattern on the media while scanning the media with the printhead at a second velocity, the absolute value of the second velocity differing from the absolute value of the first velocity; comparing the printed patterns to each other by optical means; setting the printhead scanning velocity for printing in relation to the velocity associated with the pattern having the best definition.

Abstract: A method of an embodiment of the invention is disclosed that determines calibration factors for a fluid-ejection mechanism that is capable of ejecting differently colored fluids onto media. The energy used to eject fluid for each of at least one of the fluid colors is adjusted based on the calibration factors, so that fluid drop ejections of the fluid colors yield fluid drop masses having a consistent ratio.