Abstract: A needle safety clip including means to cover the end of a needle, e.g., after use, and allowing for another medical instrument, e.g., a guidewire or a catheter to extend from the clip with the needle-sharp end secured in the clip. A distal end section of the safety clip includes a slot to receive the guidewire therethrough in a safety position while blocking the needle from moving distally past the distal end section.

Abstract: A catheter inserter (100) including an actuator assembly (125) to move a catheter assembly outside a housing (101) by engaging the catheter assembly multiple times, in an example. The inserter includes a needle assembly (140) in a housing that has a first position with a needle extending from the housing and a second position with the needle retracted into the housing. A catheter assembly (180) is removably positioned in the housing and includes a catheter (181) and a hub (182) connected to the catheter. An actuator assembly (125) is further mounted to the housing and operates to selectively engage a guidewire assembly to move the guidewire past the needle and to selectively engage the catheter assembly to move the catheter and the hub outside the housing.

Abstract: A catheter inserter including an actuator assembly to move a catheter assembly outside a housing by engaging the catheter assembly multiple times, in an example. The inserter includes a needle assembly in a housing that has a first position with a needle extending from the housing and a second position with the needle retracted into the housing. A catheter assembly is removably positioned in the housing and includes a catheter and a hub connected to the catheter. An actuator assembly is further mounted to the housing and operates to selectively engage a guidewire assembly to move the guidewire past the needle and to selectively engage the catheter assembly to move the catheter and the hub outside the housing.

Abstract: Method and apparatus for managing data buffers in a data storage device. In some embodiments, a write manager circuit stores user data blocks in a write cache pending transfer to a non-volatile memory (NVM). The write manager circuit sets a write cache bit value in a forward map describing the NVM to a first value upon storage of the user data blocks in the write cache, and subsequently sets the write cache bit value to a second value upon transfer of the user data blocks to the NVM. A read manager circuit accesses the write cache bit value in response to a read command for the user data blocks. The read manager circuit searches the write cache for the user data blocks responsive to the first value, and retrieves the requested user data blocks from the NVM without searching the write cache responsive to the second value.

Abstract: A data storage system may have a number of data storage devices that each have a non-volatile memory connected to a memory buffer. The memory buffer can consist of a map unit having a predetermined size. In receipt of a data sector into the map unit of the memory buffer, the data sector may be identified as a runt with a runt module connected to the memory buffer and the non-volatile memory. The runt module can generate and subsequently execute a runt handling plan to fill the size of the map unit before storing the filled map unit in the non-volatile memory.

Abstract: A needle safety clip including means to cover the end of a needle, e.g., after use, and allowing for another medical instrument, e.g., a guidewire or a catheter to extend from the clip with the needle-sharp end secured in the clip. A distal end section of the safety clip includes a slot to receive the guidewire therethrough in a safety position while blocking the needle from moving distally past the distal end section.

Abstract: Method and apparatus for managing data buffers in a data storage device. In some embodiments, a write manager circuit stores user data blocks in a write cache pending transfer to a non-volatile memory (NVM). The write manager circuit sets a write cache bit value in a forward map describing the NVM to a first value upon storage of the user data blocks in the write cache, and subsequently sets the write cache bit value to a second value upon transfer of the user data blocks to the NVM. A read manager circuit accesses the write cache bit value in response to a read command for the user data blocks. The read manager circuit searches the write cache for the user data blocks responsive to the first value, and retrieves the requested user data blocks from the NVM without searching the write cache responsive to the second value.

Abstract: A data storage system may have a number of data storage devices that each have a non-volatile memory connected to a memory buffer. The memory buffer can consist of a map unit having a predetermined size. In receipt of a data sector into the map unit of the memory buffer, the data sector may be identified as a runt with a runt module connected to the memory buffer and the non-volatile memory. The runt module can generate and subsequently execute a runt handling plan to fill the size of the map unit before storing the filled map unit in the non-volatile memory.

Abstract: A catheter inserter including an actuator assembly to move a catheter assembly outside a housing by engaging the catheter assembly multiple times, in an example. The inserter includes a needle assembly in a housing that has a first position with a needle extending from the housing and a second position with the needle retracted into the housing. A catheter assembly is removably positioned in the housing and includes a catheter and a hub connected to the catheter. An actuator assembly is further mounted to the housing and operates to selectively engage a guidewire assembly to move the guidewire past the needle and to selectively engage the catheter assembly to move the catheter and the hub outside the housing.

Abstract: The potassium, sodium, ammonium, lysine, diethylamine, tromethamine (TRIS), piperazine, ethylenediamine and ethanolamine salt of a compound of general formula (I): wherein R1 is halo or cyano; R2 is C1-C4 alkyl; and R3 is quinolyl or phenyl substituted with methane sulfonyl; can be synthesised by a novel method and are substantially more soluble than the parent free acids in a range of solvents.

Abstract: The invention relates to a microcrystalline form of a compound which is an inhibitor of PGD2 at the CRTH2 receptor. The microcrystalline form is obtained from a simple chemical reaction without the need for a milling process.

Abstract: Method and apparatus for allowing a direct memory access unit to have access to a virtual address space is accomplished by receiving a request for memory access from the direct memory access device; determining a device identifier according to the received request for memory access; determining a memory protection schema according to the determined device identifier; and granting the direct memory access unit access to memory in accordance with the determined memory protection schema.

Abstract: A method for allocating buffer capacity includes determining at least one characteristic of a first input/output (I/O) device that is coupled to a memory device interface, the memory device interface being configured to enable data transfers between the I/O device and a memory device, and buffering data corresponding to the first I/O device in a first portion of a buffer of the memory device interface, a size of the first portion being responsive to the at least one characteristic of the first I/O device.

Abstract: Disclosed is a process for preparing novel trans-3-alkyloxy-4-hydroxytetrahydrofurans including racemic and substantially enantiomerically pure (3S,4S)-trans-3-alk(en)yloxy-4-hydroxytetrahydrofurans and (3R,4R)-trans-3-alk(en)yloxy-4-acyloxytetrahydrofurans. The disclosed process comprises the steps of reacting 3,4-epoxytetrahydrofuran with an alcohol under Lewis acid catalysis to obtain a racemic trans-3-alk(en)yloxy-4-hydroxytetrahydrofuran; contacting the trans-3-alk(en)yloxy-4-hydroxytetrahydrofuran with an acyl donor in the presence of a hydrolase enzyme to produce a mixture of a substantially enantiomerically pure (3S,4S)-trans-3-alk(en)yloxy-4-hydroxytetrahydrofuran and a substantially enantiomerically pure (3R,4R)-trans-3-alk(en)yloxy-4-acyloxytetrahydrofuran; and separating the components of the mixture by partitioning between water and a solvent immiscible with water.

Abstract: Disclosed is a process for the production of cyclopropylmethyl halides (CPMX) such as cyclopropylmethyl chloride (CPMCI) and cyclopropylmethyl bromide (CPMBr) wherein cyclopropanemethanol (CPMO) is contacted with a complex comprising a dialkyl sulfide and an N-halosuccinimide in the presence of an organic solvent.