Patents by Inventor Matthew Lubin

Matthew Lubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20070048783
    Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: October 31, 2006
    Publication date: March 1, 2007
    Applicants: Cornell Research Foundation, Inc., Regents of the University of Minnesota, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20070042419
    Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: October 31, 2006
    Publication date: February 22, 2007
    Applicants: Cornell Research Foundation, Inc., Regents of the University of Minnesota, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Patent number: 7166434
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: January 23, 2007
    Assignees: Cornell Research Foundation, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Regents of the University of Minnesota
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Patent number: 7097980
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: August 29, 2006
    Assignees: Cornell Research Foundation, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Regents of the University of Minnesota
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer, Phillip Belgrader
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20060024731
    Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: September 16, 2005
    Publication date: February 2, 2006
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20040214224
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20040203061
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: May 12, 2004
    Publication date: October 14, 2004
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Patent number: 6797470
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: September 28, 2004
    Assignees: Cornell Research Foundation, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Regents of the University of Minnesota
    Inventors: Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Publication number: 20030032016
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Application
    Filed: July 30, 2001
    Publication date: February 13, 2003
    Inventors: Francis Barany, Matthew Lubin, Phillip Belgrader
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Patent number: 6268148
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: July 31, 2001
    Inventors: Francis Barany, Matthew Lubin, Phillip Belgrader
  • Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
    Patent number: 6027889
    Abstract: The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: February 22, 2000
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, Matthew Lubin