Abstract: Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adapted to isolate and immobilize a single, physiologically active animal in a selected geometry. A multiplexed micro-chamber chip receives single animals and the microchamber chip includes individually addressable screening chambers for imaging, incubation and exposure of individual animals to selected chemical compounds. An imaging structure generates sub-cellular, high-resolution images of the physiologically active animals. A well-plate interface chip is used to deliver elements from a compound library to a single output of the chip.

Abstract: Described is a magnetic membrane mirror having a flexible membrane comprising a magnetic material and having a high reflectance. The flexible membrane is secured over a frame to enclose a volume between the frame and membrane. A transmembrane pressure is established to achieve a desired mirror shape or curvature. Curvature can be changed by modifying the transmembrane pressure by increasing or decreasing the pressure in the enclosed volume. An array of electromagnetic actuators generates individually-controlled magnetic fields to cause localized displacements of the mirror surface. The magnetic membrane mirror can be constructed with inexpensive components and can be used as a dynamic component in an adaptive optical system.

Abstract: Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adapted to isolate and immobilize a single, physiologically active animal in a selected geometry. A multiplexed micro-chamber chip receives single animals and the microchamber chip includes individually addressable screening chambers for imaging, incubation and exposure of individual animals to selected chemical compounds. An imaging structure generates sub-cellular, high-resolution images of the physiologically active animals. A well-plate interface chip is used to deliver elements from a compound library to a single output of the chip.

Abstract: Described is a magnetic membrane mirror having a flexible membrane comprising a magnetic material and having a high reflectance. The flexible membrane is secured over a frame to enclose a volume between the frame and membrane. A transmembrane pressure is established to achieve a desired mirror shape or curvature. Curvature can be changed by modifying the transmembrane pressure by increasing or decreasing the pressure in the enclosed volume. An array of electromagnetic actuators generates individually-controlled magnetic fields to cause localized displacements of the mirror surface. The magnetic membrane mirror can be constructed with inexpensive components and can be used as a dynamic component in an adaptive optical system.