Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: An example computing platform comprising is configured to (i) receive, via one or more cameras positioned on a construction site, a plurality of images, (ii) detect, within the plurality of images, a plurality of objects being worn by respective workers on the construction site, (iii) select, from the plurality of images, a set of images depicting a particular worker, and (iv) based on the selected set of images depicting the particular worker, determine a plurality of trade probabilities for the particular worker, each trade probability in the plurality of trade probabilities indicating a likelihood that the particular worker belongs to a particular trade from among a plurality of trades.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: A computer-implemented method for monitoring productivity, health and safety risks posed by activities and objects, and other signals present at industrial sites comprises: receiving data inputs from input devices at an industrial site; selecting a data model that is programmed to detect activities or objects associated with workers or equipment present at the industrial sites; applying the data inputs to the data model to receive output data specifying whether the activities or objects associated with workers or equipment are present at the industrial site; and if they are present: based the output data, determining characteristics of the activities or objects; based on the characteristics, determining whether that the activities or objects cause any productivity, health or safety risks at the industrial site; and if so, generating notifications indicating the health or safety risks at the industrial site.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: An example computing platform comprising is configured to (i) receive, via one or more cameras positioned on a construction site, a plurality of images, (ii) detect, within the plurality of images, a plurality of objects being worn by respective workers on the construction site, (iii) select, from the plurality of images, a set of images depicting a particular worker, and (iv) based on the selected set of images depicting the particular worker, determine a plurality of trade probabilities for the particular worker, each trade probability in the plurality of trade probabilities indicating a likelihood that the particular worker belongs to a particular trade from among a plurality of trades.

Abstract: A valve apparatus comprises a valve body defining a flow path therethrough, a valve member mounted within the valve body, and an actuator assembly mounted internally within the valve body. The actuator assembly comprises a piston bore and piston member defining a piston chamber therebetween, wherein at least one of the piston bore and piston member is engaged or associated with the valve member such that the valve member is moveable in accordance with fluid pressure within the piston chamber to selectively occlude the flow path.

Abstract: A computer-implemented method for monitoring productivity, health and safety risks posed by activities and objects, and other signals present at industrial sites comprises: receiving data inputs from input devices at an industrial site; selecting a data model that is programmed to detect activities or objects associated with workers or equipment present at the industrial sites; applying the data inputs to the data model to receive output data specifying whether the activities or objects associated with workers or equipment are present at the industrial site; and if they are present: based the output data, determining characteristics of the activities or objects; based on the characteristics, determining whether that the activities or objects cause any productivity, health or safety risks at the industrial site; and if so, generating notifications indicating the health or safety risks at the industrial site.

Abstract: An example computing platform comprising is configured to (i) receive, via one or more cameras positioned on a construction site, a plurality of images, (ii) detect, within the plurality of images, a plurality of objects being worn by respective workers on the construction site, (iii) select, from the plurality of images, a set of images depicting a particular worker, and (iv) based on the selected set of images depicting the particular worker, determine a plurality of trade probabilities for the particular worker, each trade probability in the plurality of trade probabilities indicating a likelihood that the particular worker belongs to a particular trade from among a plurality of trades.

Abstract: A downhole valve, such as a safety valve or sub-sea safety valve (SSSV). The downhole valve comprising: a housing; a flow path between a valve inlet and a valve outlet; a valve mechanism; and a piston member; wherein the valve mechanism is operable by actuation of the piston member to selectively open and close the flow path between the valve inlet and valve outlet; and the piston member is actuatable by a pressure differential between an annulus pressure at the valve and a pressure at the valve outlet and/or in a portion of the flow path closest to the valve outlet. The valve can comprise an opening for receiving the annular pressure that is isolated from the valve inlet and valve outlet. The downhole valve can be configured such that it prevents operation of the valve mechanism to open and/or close the flow path by a pressure differential between the valve inlet and valve outlet.

Abstract: A screen assembly, such as a downhole/sand screen assembly, comprising first and second screen portions or screens longitudinally coupled together, wherein there is provided a fluid flow path between the first and second screen portions or screen. Optionally, the first and second sleeves are coupled or connected by a centraliser or further sleeve or screen, and/or optionally by or via first and second support ring.

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis imperfecta.

Abstract: An example computing platform comprising is configured to (i) receive, via one or more cameras positioned on a construction site, a plurality of images, (ii) detect, within the plurality of images, a plurality of objects being worn by respective workers on the construction site, (iii) select, from the plurality of images, a set of images depicting a particular worker, and (iv) based on the selected set of images depicting the particular worker, determine a plurality of trade probabilities for the particular worker, each trade probability in the plurality of trade probabilities indicating a likelihood that the particular worker belongs to a particular trade from among a plurality of trades.

Abstract: A computer-implemented method and system for neural network-based recognition of trade workers present on industrial sites is presented.

Abstract: A downhole valve, such as a safety valve or sub-sea safety valve (SSSV). The downhole valve comprising: a housing; a flow path between a valve inlet and a valve outlet; a valve mechanism; and a piston member; wherein the valve mechanism is operable by actuation of the piston member to selectively open and close the flow path between the valve inlet and valve outlet; and the piston member is actuatable by a pressure differential between an annulus pressure at the valve and a pressure at the valve outlet and/or in a portion of the flow path closest to the valve outlet. The valve can comprise an opening for receiving the annular pressure that is isolated from the valve inlet and valve outlet. The downhole valve can be configured such that it prevents operation of the valve mechanism to open and/or close the flow path by a pressure differential between the valve inlet and valve outlet.