Abstract: Gas canisters are provided that include an elongate body comprising a barrel region defining a first diameter, an enclosed first end, and a neck region extending from the barrel region to an open second end defining an end wall, the elongate body defining a central axis extending between the first end and the second end; a cap attached to the neck region to close the second end of the elongate body and enclose the cavity, the cap comprising an end wall including an opening therethrough communicating with the cavity, and a seat surrounding the opening on an interior of the end wall; and a sealing member within the neck region configured to engage the seat to seal the opening, the cavity filled with pressurized fluid.

Abstract: Canisters are provided that include a cylindrical body and a cap welded to the body to define a cavity filled with carbon dioxide or other fluid. The canisters may be loaded into a medical device, e.g., to provide an energy source for operating the device. Methods for making such canisters are also provided.

Abstract: Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Abstract: Devices and methods are provided for delivering fluid into a patient's body. In an exemplary embodiment, the device may include a syringe cartridge and a syringe driver that may be coupled to the cartridge. The cartridge may include a housing including a proximal end, a distal end, and defining an interior, the cartridge further including a piston slidably disposed within the interior for delivering fluid within the interior through a port in the distal end. The driver may include a plunger for advancing the piston within the interior of the housing, a source of pressurized fluid, a valve, and an actuator member coupled to the valve for selectively opening a flow path from the source to the plunger to control flow of the pressurized fluid to advance the plunger to deliver fluid from the interior of the housing at a desired rate.

Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Abstract: Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

Abstract: Canisters are provided that include a cylindrical body and a cap welded to the body to define a cavity filled with carbon dioxide or other fluid. The canisters may be loaded into a medical device, e.g., to provide an energy source for operating the device. Methods for making such canisters are also provided.

Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Abstract: An auto-injector includes a drive assembly within a housing carrying a syringe including a needle adjacent an activation cap within the housing's distal end. The drive assembly includes a first chamber carrying a gas canister, a plunger within a second chamber coupled to the syringe, and proximal and distal chambers. The activation cap is pressed against a subject's skin to direct the drive assembly proximally to open an outlet of the canister to release pressurized gas into the first chamber, whereupon the gas enters the proximal chamber to generate a distal force to advance the drive assembly to direct the needle into the subject and enters the second chamber to advance the plunger to deliver agents from the syringe into the subject. After the plunger advances, the gas enters the distal chamber to generate a proximal force to retract the drive assembly to direct the needle back into the housing.

Abstract: Improved entity identification is provided. Reference data sourced from various data sources may be used to more accurately identify an individual to improve the ability for multiple transaction processing systems to more effectively match identities for the transmission, receipt, and linking of data records. Accordingly, various enterprises are enabled to communicate about a particular entity without each enterprise having the same identifier or having the same, accurate entity demographic information.

Abstract: An injection device for delivering an agent into a patient’s body including a drive module and an injector module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber into the second chamber. The plunger includes a proximal end including a piston and a distal end and is configured such that gas entering the second chamber causes the plunger to move from an initial position to an extended position for delivering one or more agents from the injector module, the piston including one or more passages that allow gas from the canister to pass through the piston into the second chamber around the plunger.

Abstract: Syringe drivers and injector devices are provided. The driver includes a housing including a port communicating with a gas chamber therein and connectable to an external air source, and a cavity that receives a syringe containing an agent. A drive piston within the housing includes a first end disposed adjacent the gas chamber and a second end including a plunger connectable to the syringe. A damping mechanism is provided within that housing that is coupled to the drive piston that includes a damper piston within a damping fluid chamber such that, when the drive piston is advanced by gas delivered into the gas chamber from the external source to deliver the agent from the syringe, damping fluid within the damping fluid chamber flows through an orifice or valve from a first region to the second region, thereby limiting movement of the drive piston.

Abstract: Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Abstract: Improved entity identification is provided. Reference data sourced from various data sources may be used to more accurately identify an individual to improve the ability for multiple transaction processing systems to more effectively match identities for the transmission, receipt, and linking of data records. Accordingly, various enterprises are enabled to communicate about a particular entity without each enterprise having the same identifier or having the same, accurate entity demographic information.

Abstract: Gas-powered fluid injection systems and methods are disclosed, e.g., for delivering fluids into a patient's body. An injection device comprises a driver housing which forms and/or encloses a gas pressure source, an actuation piston driven by the gas pressure source and a hydraulic fluid pressurized by movement of the actuation piston. The hydraulic fluid flows through an adjustable valve into a plunger lumen which pushes a plunger of a fluid dispensing device, such as a syringe, to dispense an injection fluid, such as a medicament. The injection device has a movable plunger sleeve which receives the plunger of the fluid dispensing device. The plunger sleeve is moved during the activation and de-activation of the injection device such that it relieves residual pressure in the fluid dispensing device thereby preventing the fluid dispensing device from continuing to dispense injection fluid after the injection device has been de-actuated.

Abstract: Identifying and addressing an individual's socio-economic factors related to negative health outcomes for reducing the likelihood of negative health outcomes for the individual in the form of readmission rates, emergency department utilization, missed appointments/no-shows, etc., may be realized by employing aspects of the present disclosure. A social determinants of health (SDoH) system accesses and analyzes consumer marketing data associated with the individual, business data, and public transportation data held by various databases for identifying indicators of SDoH factors, determines an individual's propensity for SDoH factors, and determines an engagement strategy to address SDoH that impact the individual. The results may be included in a report or included in a user interface that is transmitted to the requestor. The results may be displayed in a way that enables the requestor to easily identify and act on the individual's SDoH using recommended engagement strategies.

Abstract: A request for a most reliable demographic fields data for a selected demographic field associated with an entity may be received at an entity matching system. A plurality of records associated with the entity may be received at the entity matching system. Each of the plurality of records may include at least one demographic field. A demographic field corresponding to the selected demographic field may be identified from the at least one demographic field for each of the plurality of records. A reliability score may be determined for the corresponding demographic field for each of the plurality of records. The corresponding demographic field with the highest reliability score may be determined as the most reliable demographic fields data.

Abstract: Devices and methods are provided for delivering fluid into a patient's body. In an exemplary embodiment, the device may include a syringe cartridge and a syringe driver that may be coupled to the cartridge. The cartridge may include a housing including a proximal end, a distal end, and defining an interior, the cartridge further including a piston slidably disposed within the interior for delivering fluid within the interior through a port in the distal end. The driver may include a plunger for advancing the piston within the interior of the housing, a source of pressurized fluid, a valve, and an actuator member coupled to the valve for selectively opening a flow path from the source to the plunger to control flow of the pressurized fluid to advance the plunger to deliver fluid from the interior of the housing at a desired rate.