Abstract: The disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing having a proximal end and an opposite distal end, a dose setting member rotatable relative to the housing during dose setting and during dose dispensing, and an axially compressible torsion spring which is rotationally and axially constrained with a first end to the housing. The device further comprises a spring collar, which is rotationally constrained to the dose setting member and axially displaceable thereto between a proximal dose setting position and a distal dose dispensing position. The torsion spring is rotationally constrained with a second, opposite end to the dose setting member via the spring collar, and the torsion spring biases the spring collar into its dose setting position.

Abstract: The present disclosure is generally directed to a trigger mechanism for initiating dispensing doses of a medicament from a drug delivery device. The trigger mechanism includes a trigger element movable in a first direction relative to a counter element. To provide a feedback to a user of the trigger mechanism, the trigger element includes a first interference member and the counter element includes a second interference member located with respect to the first interference member such that upon movement of the trigger element relative to the counter element the first interference member contacts and passes over the second interference member, thereby generating an audible and/or tactile feedback. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament comprising such a trigger mechanism.

Abstract: A method for assembling a drug delivery device that includes mounting a cartridge with a bung, the mechanism, the plunger and the spring within a housing such that a spring biases a plunger in a dispensing direction and that a drum and/or the release member is attached to the plunger attaching a tool with torque measurement capability to the drum or a release member of a dose mechanism in a state where at least one housing part is detached from further housing part; setting a dose by rotating the dose setting member in a first direction, activating a trigger and monitoring the torque applied to the drum or the release member; releasing the trigger upon detection of a predetermined change in the torque measured by the tool; and releasing the tool and closing the housing.

Abstract: The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a drug delivery device. The mechanism comprises a housing having a longitudinal axis defined by a compartment for receiving a cartridge, a plunger suitable for acting on a bung of a cartridge retained in the housing, a strained pressure spring arranged between the housing and the plunger, a retaining member coupled to the plunger, and a release member operable between a first state, in which the release member constrains the retaining member to the housing, and a second state, in which the release member is movable relative to the housing.

Abstract: The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.

Abstract: The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The drive mechanism includes a base element, a toothed piston rod, which is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod. The toothed piston rod includes multiple rigid rod pieces which are connected by hinges. The rigid rod pieces comprise a flat plate provided with a straight toothed rack.

Abstract: The present invention relates to a drug delivery device comprising a dose setting member (70) for setting user variable doses of a medicament and a display for indicating the dose set by the dose setting member (70). The display comprises a number wheel (100), which is rotationally coupled to the dose setting member (70) and is provided with a series of markings on its outer circumference, and at least one prism (90) deviating the image of the markings of the number wheel (100), e.g. by 90°.

Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having an opening, a dose selector operable to set a dose by rotation relative to the housing, a release member controlling movement of a piston in a dispensing direction, and a display comprising a units number wheel and a tens number wheel which are coupled to each other such that a continuous rotation of the units number wheel is translated into an intermittent rotary motion of the tens number wheel. The release member rotates, during dose dispensing, an angle corresponding to the dose set by the dose selector, thereby allowing a piston to move in a dispensing direction.

Abstract: The disclosure is directed to a drive mechanism for use in a drug delivery device having a cartridge, the mechanism comprising a base element, a toothed piston rod movable from a first retracted position corresponding to a full cartridge to a second extended position corresponding to an empty cartridge, wherein the piston rod is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod, wherein the toothed piston rod comprises multiple rigid rod pieces which are connected by hinges, and a drive spring, which is fixed to the base element with one end and fixed to the drive gear with another end and which exerts a force or torque to the drive gear for rotating the drive gear relative to the base element, which rotation results in a movement of the toothed piston rod.

Abstract: The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve.

Abstract: The present disclosure is generally directed to a clicker arrangement for use in a drug delivery device, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The clicker arrangement comprises a first element rotatable at least in a first direction and a second, non-rotatable element. The first element is axially displaceable relative to the second element between a first position and a second position. One of the elements comprises a clicker arm and the other comprises a protrusion wherein upon rotation of the first element in the first direction relative to the second element the clicker arm is elastically deflectable in a radial direction by the protrusion and relaxable in the opposite radial direction upon disengagement with the protrusion thereby generating an audible and/or tactile feedback signal.

Abstract: A dose setting mechanism comprising a first element and a second element; the first element being moveable with respect to the second element; the first element and the second element being coupled by a ratchet mechanism allowing motion of the first element with respect to the second element from a first position to a second position only in a first direction while preventing motion in a second direction that is opposite to the first direction; once passing the second position, the first element being moveable with respect to the second element in the first direction and in the second direction.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a non-numerical display for such a device. The display comprises a housing with at least one window, a dosing element movable relative to the housing during dose setting and/or dose dispensing, and a movable indicator element visible through the at least one window The indicator element is coupled to the dosing element and/or to the housing such that it moves not proportional to the dosing element.

Abstract: The present invention is generally directed to a dose setting mechanism and a drug delivery device herewith, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The dose setting mechanism comprises a dose setting member (50) rotatable relative to a housing (10, 20) in a first direction for dose setting and in an opposite second direction for dose correcting, a cam ring (150) and a coupling member (70) coupled to a drive member (110). A ramped interface (52, 152) is provided between the dose setting member (50) and the cam ring (150) such that rotation of the dose setting member (50) relative to the cam ring (150) in the second direction causes axial displacement of the cam ring (150).

Abstract: The present disclosure concerns a mechanism for setting a dose of a medicament for a variable dose drug delivery device, comprising: a housing, a sleeve component configured to rotate relative to the housing during a dose setting operation, and a stop member which is configured to limit a total amount of possible rotation of the sleeve component to a maximum and, thereby, to limit a maximum settable dose, wherein the stop member is configured to allow varying the maximum which determines the total amount of possible rotation of the sleeve component.

Abstract: A dose setting mechanism for a drug delivery device includes a primary drug delivery assembly and a secondary drug delivery assembly. The dose setting mechanism includes a primary dose dial component for setting a dose in the primary drug delivery assembly and a secondary dose dial component for setting a dose in the secondary drug delivery assembly. The primary dose dial component and the secondary dose dial component are configured to rotate during dose setting. A gear mechanism is configured such that in a first phase of the dose setting, rotation of the primary dose dial component is transferred to the secondary dose dial component and such that in a second phase of the dose setting, the secondary dose dial component is decoupled from the primary dose dial component such that rotation of the primary dose dial component is prevented from being transferred to the secondary dose dial component.

Abstract: The invention is directed to drug delivery device comprising a primary drug delivery assembly (3) with a primary dose dial sleeve (17) and a secondary drug delivery assembly (4) with a secondary drive sleeve (24). For user selection, a selection switch (48) is movable between a first, a second and a third position and a clutch (49) is connected to the selection switch (48) such that movement of the selection switch (48) causes rotation of the clutch (49). A secondary drive sleeve (24) is configured to rotate and to engage the clutch (49), wherein the clutch (49) is configured to transfer rotation to the secondary drive sleeve (24) when the selection switch (48) is moved from the first position into the second position and to disengage from the secondary drive sleeve (24) when the selection switch (48) is moved from the first into the third position.

Abstract: The invention is directed to a differential gear mechanism (26) for a drug delivery device with a primary drug delivery assembly (3) and a secondary drug delivery assembly (4), wherein the primary drug delivery assembly (3) comprises a primary dose dial sleeve (17) and wherein the secondary drug delivery assembly (4) comprises a secondary drive sleeve (24). The invention is also directed to a respective drug delivery device.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.

Abstract: The invention is directed to a drug delivery device (1) comprising a primary drug delivery assembly (3) for the delivery of a primary medicament with a primary dose setting mechanism (8) and a secondary drug delivery assembly (4) for the delivery of a secondary medicament. A selection element (13) is movable in a first and a second direction and configured such that movement of the selection element (13) in the first direction and in the second direction causes the setting of an increasing dose in the primary dose setting mechanism (8).