Abstract: An electrochemical cell frame for an electrolysis application utilizing an electrochemical cell is provided. The electrochemical cell frame can include a frame body, an internal sealing member, and an external sealing member. The frame body can be formed from a polymer material. The frame can define an active area, a flow passage, and a port. The active area can be configured to accommodate the electrochemical cell. The flow passage can be configured to direct fluid flow into or out of the active area. The port can be fluidly connected to the flow passage. The internal sealing member can be integrally formed with the frame body and positioned to separate fluid streams within the electrochemical cell. The external sealing member can be integrally formed with the frame body and positioned to militate against fluid leakage from the electrochemical cell.