Abstract: An investment manager engine automatically manages an investment fund. During an accumulation phase, the investment manager receives messages that include contributions to the investment fund. For each contribution, the investment manager determines an allocation of the contribution among securities and guaranteed income assets. The investment manager allocates at least a portion of the contribution to guaranteed income assets, according to the determined allocation. The guaranteed income assets provide a guaranteed annual income stream upon a predetermined date.

Abstract: An investment manager engine automatically manages an investment fund. During an accumulation phase, the investment manager receives messages that include contributions to the investment fund. For each contribution, the investment manager determines an allocation of the contribution among securities and guaranteed income assets. The investment manager allocates at least a portion of the contribution to guaranteed income assets, according to the determined allocation. The guaranteed income assets provide a guaranteed annual income stream upon a predetermined date.

Abstract: The present disclosure provides antisense oligonucleotides, compositions, and methods that target ATP7B exon 6 or a flanking intron, thereby modulating splicing of ATP7B pre-mRNA to increase the level of ATP7B mRNA molecules having exon 6, e.g., to provide a therapy for Wilson disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to an ATP7B target sequence in exon 6, a 5?-flanking intron, a 3?-flanking intron, or a combination of exon 6 and the 5?-flanking or 3?-flanking intron.

Abstract: The present disclosure provides antisense oligonucleotides, compositions, and methods that target ATP7B exon 6 or a flanking intron, thereby modulating splicing of ATP7B pre-mRNA to increase the level of ATP7B mRNA molecules having exon 6, e.g., to provide a therapy for Wilson disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to an ATP7B target sequence in exon 6, a 5?-flanking intron, a 3?-flanking intron, or a combination of exon 6 and the 5?-flanking or 3?-flanking intron.

Abstract: A method and apparatus for isolating and purifying a 213Bi radioactive isotope from an 225Ac source using a primary column and a primary sorbent which preferentially retains 225Ac over 213Bi when exposed to a compatible solvent in combination with a secondary column having a secondary sorbent which retains 213Bi when exposed to a mixture of the compatible solvent and 213Bi. A “compatible solvent” is a solvent which will preferentially remove 213Bi radioactive isotopes from a primary sorbent without removing 225Ac radioactive isotopes, and then allow 213Bi radioactive isotopes removed from the primary sorbent to be retained on a secondary sorbent, without having to dilute or otherwise chemically or physically modify the compatible solvent in between exposure to the primary and secondary sorbents.

Abstract: A disk drive uses seek profile manipulation to provide enhanced transducer fly height control. The maximum seek velocity that is used during a seek operation is made dependent upon, among other things, the direction associated with the seek operation (i.e., either radially inward or radially outward with respect to the disk). In a preferred embodiment, the maximum seek velocity in a direction that normally results in a fly height loss is made less than the maximum seek velocity in the opposite direction. Thus, a minimum transducer fly height can be maintained with minimal effect on average seek time in the disk drive. In one approach, the maximum seek velocity values are stored within a lookup table within the disk drive.

Abstract: Sliders having air bearing surfaces are disclosed for use with magnetic recording and reading heads in a magnetic disk drive assembly to reduce the pressure gradients resulting from the flow of air between the slider and the spinning disk. To relieve such pressure gradient, the bottom surface of the air bearing surface at or near the trailing edge includes one or more recesses, which may be one or more steps, inclined ramps, curves or other configurations. Other surfaces of the slider may also include recesses to relieve these pressures. The sliders having air bearing surfaces may be attached to, or integral with, a magnetic recording or reading head in a magnetic disk drive assembly. A method of reducing the formation of pressure gradients is also disclosed whereby air flow between the disk and the head creates a pressure greater than atmospheric, at least a part of which is released through a recess on the air bearing surface of the slider.

Abstract: A slider support structure is disclosed for minimizing off-rack due to disk flutter. In one embodiment, the slider support structure includes a gimbal assembly (306). The assembly (306) includes an outer ring (500) and an inner ring (502). The outer ring (500) is connected to the inner ring (502) via narrow strips (504 and 506) adjacent to the front (508) and back (510) surfaces of the slider body (512). The inner ring (502) is attached to the left (514) and right (516) surfaces of the slider body (512) via narrow strips (518 and 520). The strips (504 and 506) interconnecting the inner ring (502) and outer ring (500) define a flexible hinge that allows the slider body (512) to pivot relative to the assembly (306) about an axis (522) which, in this case, is the roll axis. Similarly, the strips (518 and 520) define a flexible hinge which allows the slider to pivot relative to the assembly (306) about another axis (524) which, in this case, is the pitch axis.