Patents by Inventor Matthew P. Jacobson

Matthew P. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NURR1 RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20230255934
    Abstract: Described herein, inter alia, are Nurr1 receptor modulators and uses thereof.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 17, 2023
    Inventors: Pamela M. England, Matthew P. Jacobson
  • SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20230255963
    Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: April 20, 2023
    Publication date: August 17, 2023
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Matthew P. Jacobson
  • NURR1 RECEPTOR MODULATORS
    Publication number: 20230063230
    Abstract: Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.
    Type: Application
    Filed: February 19, 2020
    Publication date: March 2, 2023
    Applicants: The Regents of the University of California, ShangPharma Innovation Inc.
    Inventors: Pamela M. England, Matthew P. Jacobson, Richard Beresis
  • SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20220125786
    Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Matthew P. Jacobson
  • SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20210290619
    Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 23, 2021
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Matthew P. Jacobson
  • SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20170107199
    Abstract: Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: December 27, 2016
    Publication date: April 20, 2017
    Inventors: Brian W. METCALF, Chihyuan CHUANG, Jeffrey WARRINGTON, Matthew P. JACOBSON
  • SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20160206614
    Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: March 25, 2016
    Publication date: July 21, 2016
    Inventors: Brian METCALF, Chihyuan CHUANG, Jeffrey WARRINGTON, Kumar PAULVANNAN, Matthew P. JACOBSON, Lan HUA, Bradley MORGAN
  • SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20150344472
    Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: March 18, 2015
    Publication date: December 3, 2015
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Kumar Paulvannan, Matthew P. Jacobson, Lan Hua, Bradley Morgan
  • SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
    Publication number: 20150344483
    Abstract: Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Application
    Filed: March 18, 2015
    Publication date: December 3, 2015
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Kumar Paulvannan, Matthew P. Jacobson, Lan Hua, Bradley Morgan
  • Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
    Patent number: 9012450
    Abstract: Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: April 21, 2015
    Assignees: Global Blood Therapeutics, Inc., Cytokinetics, Inc., The Regents of the University of California
    Inventors: Brian Metcalf, Chihyuan Chuang, Jeffrey Warrington, Kumar Paulvannan, Matthew P. Jacobson, Lan Hua, Bradley Morgan
  • NOVEL LIPOXYGENASE INHIBITORS AS NEUROPROTECTIVE AGENTS
    Publication number: 20120053220
    Abstract: The present invention relates to the identification of inhibitors of lipoxygenase enzymes. Methods are presented for using novel lipoxygenase inhibitors: LOXBlock-1 and LOXBlock-3, and other candidate lipoxygenase inhibitors identified by similar screening strategies, in therapy and diagnostics for neurodegenerative disorders.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 1, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Florey Neuroscience Institutes, The Regents of the University of California
    Inventors: Klaus Van Leyen, Theodore R. Holman, Eng H. Lo, Matthew P. Jacobson, David W. Howells