Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: Systems and methods for golf analysis including a tag coupled to a golf club providing statistical analytics for coaching including text, tabular, graphic, and image-based outputs that include trends information for the golfer, all based upon actual golf play on course situations, wherein the golfer inputs shot data during play, without interrupting the flow of the game, and uploads the shot data for analytics and review online, and wherein all information related to a given user are reviewable by an authorized coach user through a web-based coach access account. The system is further operable to provide the coach user rights for providing corrective or instructive feedback to the user, including visual recommendations such as modified target areas.

Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of several reference protein structures, e.g., related antibody epitopes or protein binding sites. A Machine Learning (ML) model may be used to generate engineered polypeptides. After substituting target residues for corresponding residues in other reference structures in the same scaffold, the scaffolds with each set of target residues may be filtered by structural comparison to identify generalized scaffolds. Generalized scaffolds may be improved by screening libraries of polypeptides.

Abstract: Provided herein are PD-1 agonist antibodies which bind PD-1. The PD-1 agonist antibodies of the disclosure are useful for the treatment of autoimmune and inflammatory diseases through the promotion of PD-1 signaling. Also provided herein are methods of use for the PD-1 agonist antibodies.

Abstract: A system, method, and computer program product for representing at least one of a user process and a system process as a software package in a software package management system. The method includes creating at least one package comprising at least one of a user process and a system process. The at least one package comprises a structure consistent with a software package so that the at least one package is able to be managed by a software package management system. The at least one package is stored on an information system via the software package management system.

Abstract: An apparatus and method for provisioning software on a network of heterogeneous computers in a network. The provisioner receives a list of packages and deployment scope of the packages, then checks each node for installed applications and records dependency and potential application conflicts. In addition, the provisioner measures a plurality of network and node metrics. Based on the dependency information, conflict information, and metrics, one or more nodes are selected and software is provisioned and/or removed in accordance with the dependency and conflict information.

Abstract: An apparatus and method for scheduling a job process on at least one node in a server data processing network. The scheduling is based on a state of at least two nodes in the network as well as a cost metric of installing a required application on at least one of the nodes in the network of nodes. The apparatus and method gathers metrics indicating properties associated with at least two nodes on the network, the metrics including a presence of an application necessary for running the process. A first cost factor for scheduling the process on a node in the network having the application necessary for running the process is compared with a second cost factor for scheduling the process on a node in the network that does not have the application necessary for running the process. Finally, a node in the network is selected for scheduling the process.

Abstract: A memory emulation test system is provided with a method of and system for fast functional testing of memories, such as boot ROMs, in microprocessor-based assemblies. The emulative test system includes a synchronization circuit which automatically re-arms itself and generates sync pulses on each and every UUT data access cycle to allow the UUT microprocessor to read every boot ROM memory location and collect data to be computed into a checksum or other signature to be compared with a predetermined signature representative of a correctly functioning and faultless boot ROM.

Abstract: A method of functionally testing cache tag RAMs in processor systems where the kernel is typically inaccessible. A test program first determines whether a fault exists at all within the cache tag RAM. If a fault is determined to exist, the faulty RAM location is exercised by sequentially applying patterns of ones and zeros until the pattern of bits actually present at the faulty tag RAM location is determined. A comparison of this pattern of bits with the expected bit pattern provides information as the precise location of the fault so as to permit replacement of defective chips.