Abstract: Disclosed herein is a method of treating endometrial cancer by administering to the subject a solid pharmaceutical composition comprising 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile or a pharmaceutically-acceptable salt thereof, alone or in combination with a second agent such as letrozole.

Abstract: Disclosed herein is a method of treating ovarian cancer by administering to the subject a solid pharmaceutical composition comprising 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile or a pharmaceutically-acceptable salt thereof, alone or in combination with a second agent such as letrozole.

Abstract: Disclosed herein is a method of treating a cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a first compound, or a pharmaceutically-acceptable salt or zwitterion thereof, and a therapeutically-effective amount of a second compound, or a pharmaceutically-acceptable salt thereof.

Abstract: Disclosed herein is a method of treating a squamous cell carcinoma (SCC), a SCC associated with a disease, for example, recessive dystrophic epidermolysis bullosa (RDEB). The method of the disclosure describes administering a therapeutically-effective amount of (E)-2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)acetic acid, or a pharmaceutically-acceptable salt or zwitterion thereof, and derivatives thereof.

Abstract: RAS proteins are frequently mutated in human cancers. Disclosed herein are compounds that disrupt RAS effectors and inhibits Ras/Raf/MEK/ERK pathway signaling. Further disclosed herein are methods of using compounds in combination with checkpoint inhibitors to treat cancer.

Abstract: Techniques are provided for providing Doppler correction. In particular, embodiments may provide re-banding circuitry having a reference clock, a mixer, and a compensation circuitry for re-banding and for Doppler correction. The compensation circuitry may be configured to adjust a reference frequency of the reference clock based on signals received from a Global Navigation Satellite System (GNSS) receiver. The mixer may be configured to translate communication signals in a first frequency band to a second frequency band based at least in part on the adjusted reference frequency of the reference clock.

Abstract: An inertial measurement unit includes a substrate having MEMS gyroscopes arranged on the substrate as opposing pairs. The gyroscopes of each opposing pair are arranged on opposite sides of an axis of rotation of the substrate and each opposing pair has a central axis that intersects an axis of rotation of the substrate. A processor receives a rotational measurement from each gyroscope, compares the measurements from gyroscopes of each opposing pair, determines a mean or median rotation value for each opposing pair, and compares the mean or median rotation value with a threshold value. The processor assigns a weight to the mean or median value for each opposing pair and determines a rotation of the cuboid inertial measurement unit based on the mean or median value for each opposing pair and the respective weight for the mean or median value for each opposing pair.

Abstract: Techniques are provided herein for providing power efficiency for re-bander units. In particular, embodiments may provide for powering up of a power amplifier in the transmit path of the re-bander on demand, when a transmit signal is to be transmitted. Circuitry controlling the powering up of the power amplifier may do so based on a transmit indicator signal, indicating the presence of a transmit signal received by the re-bander unit. The transmit indicator signal may be a strobe signal received by a user equipment (UE) to which the re-bander unit is coupled, or may be derived from detection of the transmit signal by a directional coupler and power detector.

Abstract: Techniques are provided herein for providing power efficiency for re-bander units. In particular, embodiments may provide for powering up of a power amplifier in the transmit path of the re-bander on demand, when a transmit signal is to be transmitted. Circuitry controlling the powering up of the power amplifier may do so based on a transmit indicator signal, indicating the presence of a transmit signal received by the re-bander unit. The transmit indicator signal may be a strobe signal received by a user equipment (UE) to which the re-bander unit is coupled, or may be derived from detection of the transmit signal by a directional coupler and power detector.

Abstract: An inertial measurement unit includes a substrate having MEMS gyroscopes arranged on the substrate as opposing pairs. The gyroscopes of each opposing pair are arranged on opposite sides of an axis of rotation of the substrate and each opposing pair has a central axis that intersects an axis of rotation of the substrate. A processor receives a rotational measurement from each gyroscope, compares the measurements from gyroscopes of each opposing pair, determines a mean or median rotation value for each opposing pair, and compares the mean or median rotation value with a threshold value. The processor assigns a weight to the mean or median value for each opposing pair and determines a rotation of the cuboid inertial measurement unit based on the mean or median value for each opposing pair and the respective weight for the mean or median value for each opposing pair.

Abstract: Techniques are provided for providing Doppler correction. In particular, embodiments may provide re-banding circuitry having a reference clock, a mixer, and a compensation circuitry for re-banding and for Doppler correction. The compensation circuitry may be configured to adjust a reference frequency of the reference clock based on signals received from a Global Navigation Satellite System (GNSS) receiver. The mixer may be configured to translate communication signals in a first frequency band to a second frequency band based at least in part on the adjusted reference frequency of the reference clock.

Abstract: The invention provides compositions and methods for treating cancer with glufosfamide in combination with an inhibitor of sodium-glucose transporter type 2 (SGLT2) to block the uptake of glucose in the proximal tubules of the kidneys to decrease renal toxicity. The invention relates to the fields of biomedicine, pharmacology, and molecular biology.

Abstract: Apparatus and methods for handling spent catalyst, wherein a slurry comprising the catalyst may be rapidly and conveniently drained to separate a liquid from the catalyst using a separation unit including a separation vessel and having a separator plate disposed between an upper compartment and a lower compartment of the separation vessel, whereby each of the liquid and solid components of the slurry may be conveniently contained separately for subsequent treatment, transportation, and/or disposal.

Abstract: A non-aqueous, substantially solvent-free and photoinitiator-free, particle beam curable ink having a viscosity less than 30 m Pa—s at 60° C., comprising: (i) a colorant; and (ii) a mixture of (meth)acrylate compounds; wherein: (a) the colorant is present in the ink in an amount of 0.1 to 14.9% by weight relative to the total weight of ink; and (b) the mixture of (meth)acrylate compounds comprises c % of one or more mono (meth)acrylate compounds, d % of one or more di (meth)acrylate compounds and e % of one or more compounds having three or more (meth)acrylate groups, wherein the values of c %, d % and e % are by weight relative to the total weight of the mono (meth)acrylate compounds, di (meth)acrylate compounds and compounds having three or more (meth)acrylate groups and are such that the value of Formula (1) is less than or equal to 60: c ? ? ? % + 0.

Abstract: A method is provided for preserving the integrity of stretchy polymer fibres.