Patents by Inventor Matthew Paul Leese

Matthew Paul Leese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
    Patent number: 8030296
    Abstract: There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: October 4, 2011
    Assignee: Sterix Limited
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Lok Wai Lawrence Woo, Hatem Hejaz, Bertrand Leblond, Matthew Paul Leese, Atul Purohit
  • Thioether sulphamate steroids as steroid inhibitors and anti-cancer compounds
    Patent number: 7342004
    Abstract: There is provided use of a compound of Formula XI: wherein R3 is a sulphamate group and at least of R1 or R2 is a thioether group as disclosed by the present specification, capable of inhibiting steroid sulphatase.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: March 11, 2008
    Assignee: Sterix Ltd.
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Graham Keith Packham, Matthew Paul Leese
  • Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
    Patent number: 7119081
    Abstract: There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: October 10, 2006
    Assignee: Sterix Limited
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Bertrand Leblond, Matthew Paul Leese, Atul Purohit
  • 17-aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase
    Patent number: 7067503
    Abstract: There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula —L-R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: June 27, 2006
    Assignee: Sterix Limited
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Bertrand Leblond, Matthew Paul Leese
  • Thioether sulphamate steroids as steroid inhibtors and anti-cancer compounds
    Publication number: 20040009959
    Abstract: There is provided use of a compound in the manufacture of a medicament to inhibit superoxide dismutase (SOD) or for use in the therapy of a condition or disease associated with SOD wherein the compound is of Formula I 1
    Type: Application
    Filed: February 14, 2003
    Publication date: January 15, 2004
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Graham Keith Packham, Matthew Paul Leese
  • Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
    Publication number: 20030225051
    Abstract: There is provided a compound of Formula I 1
    Type: Application
    Filed: February 14, 2003
    Publication date: December 4, 2003
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Lok Wai Lawrence Woo, Hatem Hejaz, Bertrand Leblond, Matthew Paul Leese, Atul Purohit
  • 17-Aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase
    Publication number: 20030203855
    Abstract: There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula —L—R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group.
    Type: Application
    Filed: February 14, 2003
    Publication date: October 30, 2003
    Inventors: Barry Victor Lloyd Potter, Michael John Reed, Bertrand Leblond, Matthew Paul Leese