Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A hydraulic motor comprising a housing having a fluid inlet. A fluid outlet and a cavity there between, a pair of intermeshing gear elements rotatable in the housing about mutually parallel axes. Each of the gear elements having a set of gear teeth disposed about the periphery of the element and a support shaft extending from oppositely directed end faces of the set of gear teeth. A bearing assembly located on opposite sides of the cavity in said housing to support the shafts for rotation about respective ones of the axes. Each of the bearing assemblies having a sealing face overlying the end faces and biased into engage with the end faced by a pressure compensating seal located between the bearing and the housing. The sealing face having a channel extending partially about the spindle and in fluid communication with the inlet to introduce fluid under pressure between the faces.