Patents by Inventor Matthew Petroff

Matthew Petroff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADENO-ASSOCIATED VIRUS FORMULATIONS
    Publication number: 20250387510
    Abstract: Compositions and methods for the formulation and use of recombinant adeno-associated viruses (rAAVs) are described. In certain embodiments, the application discloses recombinant Adeno-Associated Virus (rAAV or AAV) formulations that provide for one or more of the following: maintain stable freeze-thaw and lyophilization (freeze-drying) performance, and enable longer term shelf storage at temperatures above-80° C. while maintaining critical quality attributes such as genome recovery, retention of potency, minimal aggregation and degradation, improved vector quality, retaining viral protein (VP) ratios, maximum chemical stability (minimal deamidation and oxidation) and/or improved thermodynamic stability.
    Type: Application
    Filed: June 23, 2025
    Publication date: December 25, 2025
    Applicant: Spark Therapeutics, Inc.
    Inventors: Smrithi Padmakumar, Vineet Kumar, Matthew Petroff, Karen Collette Baker, Leslie Lam
  • Process for preparing recombinant insulin using microfiltration
    Patent number: 10562951
    Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 18, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
  • PROCESS FOR PREPARING RECOMBINANT INSULIN USING MICROFILTRATION
    Publication number: 20180044395
    Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff