Patents by Inventor Matthew Pettroff

Matthew Pettroff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of fusion proteins
    Patent number: 9556258
    Abstract: The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: January 31, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joseph Nti-Gyabaah, Ijeoma Ikechukwu, Matthew Pettroff, Christine Cho Lee
  • PURIFICATION OF FUSION PROTEINS
    Publication number: 20140187751
    Abstract: The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
    Type: Application
    Filed: July 3, 2012
    Publication date: July 3, 2014
    Applicant: MERCK
    Inventors: Joseph Nti-Gyabaah, Ijeoma Ikechukwu, Matthew Pettroff, Christine Cho Lee