Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PAR-2 and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human PAR-2 block the interaction between a PAR-2 activating ligand and an extracellular domain of PAR-2, and/or blocks PAR-2 activation by a PAR-2 activating ligand, In further aspects, the antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased expression of PAR-2 and/or diseases or conditions that can be alleviated by antagonizing activation of PAR-2 by a PAR-2 activating ligand (e.g., airway diseases, skin diseases, cancer, orofacial granulomatosis, inflammatory conditions, and pain associated with various diseases or conditions).

Abstract: A load-modulated amplifier system is disclosed having a main amplifier with drain or collector voltage bias input, and an auxiliary amplifier having a static drain or collector voltage bias input. Also disclosed is a programmable voltage bias controller having a data interface configured to receive operating traffic level data symbol data associated with a basestation. The programmable bias controller further includes a processor coupled to the data interface and configured, in response to the traffic or symbol data, to determine and apply bias levels to the carrier drain or collector bias input and the auxiliary drain or collector bias input and to provide an amplifier efficiency theoretically between 60% and 78.5% over the low traffic operation zone ?9 dB to ?15 dB backed off from amplifier peak power.

Abstract: An apparatus has a processor and a memory connected to the processor. The memory stores instructions executed by the processor to store identity attributes including real identity attributes for a real individual and at least two sets of digital identity attributes each operative as a personal privacy proxy with compartmental identity attributes. The at least two sets of digital identity attributes each include a digital identity name, a digital identity mobile device number and a digital identity email address. The at least two sets of digital identity attributes are evaluated to produce a similarity measure. The real individual is provided with a recommendation based upon the similarity measure.

Abstract: An apparatus has a processor and a memory connected to the processor. The memory stores instructions executed by the processor to compute computer network activity reputation attributes for a digital identity. The digital identity has identity attributes different than identity attributes associated with a real individual utilizing the digital identity for computer network activity. The storage of the computer network activity reputation attributes for the digital identity is coordinated within a block chain system distributed across a block chain network of computers. Computer network activity reputation attributes for the digital identity are supplied in response to a request from a machine. The computer network activity reputation attributes are communicated over a network of computers to the machine.

Abstract: The present invention is a hybrid integrated circuit comprising at least two semiconductor dies. A high performance semiconductor die includes high performance epitaxy layers grown on a donor substrate, which may form active devices such as transistors. A supporting semiconductor die includes epitaxy layers of a commercially available technology and grown on a native substrate to form passive devices such as resistors, capacitors, inductors, backside via holes, or active devices such as transistors The semiconductor dies are attached to a metallic mounting structure and may be electrically interconnected using traditional IC interconnect methods, such as wire bonding. The metallic mounting structure may function as a grounding base, which may be formed of electrically conductive metal such as copper. The high performance epitaxy layers may include GaN epitaxy layers, AlGaN epitaxy layers, SiC epitaxy layers, or a combination of the three.

Abstract: A method and apparatus for providing remote control of the output power level of an amplifier. The method uses pulse width or pulse density modulated signal proportional to the power level of the amplifier. This signal is detected and filtered to provide a control voltage to the apparatus mentioned below. The apparatus includes an amplifier, and a comparator having a first input coupled to an output terminal of the amplifier, a second input coupled to a control signal, and an output terminal coupled to an input terminal of the amplifier. The amplifier and comparator operate to form a feedback loop which functions to equalize the voltage level of an output signal present at the output terminal of the amplifier to the voltage level of the control signal. The equalization of the voltage level of the output signal of the amplifier to the voltage level of the control signal is effected by adjusting the drain current flowing through the amplifier.