Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: The present invention relates to a method for producing a three-dimensional (3D) printed article with a photocurable silicone composition involving a silicone containing as end-group specific (meth)acrylate groups.

Abstract: Detecting analytes using proximity-induced tagmentation, strand invasion, restriction, or ligation is provided herein. In some examples, detecting an analyte includes coupling a donor recognition probe to a first portion of the analyte. The donor recognition probe includes a first recognition element specific to the first portion of the analyte, a first oligonucleotide corresponding to the first portion, and a transposase coupled to the first recognition element and the first oligonucleotide. An acceptor recognition probe is coupled to a second portion of the analyte. The acceptor recognition probe includes a second recognition element specific to the second portion of the analyte and a second oligonucleotide coupled to the second recognition element and corresponding to the second portion. The transposase is used to generate a reporter polynucleotide including the first and second oligonucleotides. The analyte is detected based on the reporter including comprising the first and second oligonucleotides.

Abstract: An electric vehicle supply equipment (EVSE) is provided with an integrated arc fault detection circuit interruption (AFCI) device to supply electricity to an electric vehicle (EV) being a load. The EVSE comprises a coupler and an AFCI device including: a controller including a processor and a memory, circuitry and computer-readable firmware code stored in the memory which, when executed by the processor, causes the controller to: detect an arcing level of arcing between the coupler and a charge port of the EV or any other series or parallel arcing within the EVSE, compare the arcing level to a threshold level to determine a hazardous nature of arching, and analyze the arcing level to determine not only if it is currently hazardous but if it is likely to become hazardous in a near term and recommend repair or replacement of the coupler and the charge port before damage occurs.

Abstract: Methods, apparatus, systems and articles of manufacture to monitor media are disclosed. An example apparatus includes memory; computer readable instructions; and processor circuitry to execute the computer readable instructions to: generate a plurality of errors by comparing (a) a plurality of watermarks adjusted by offsets and (b) reference data, the adjusted watermarks corresponding to watermark data with inaccurate timing information for media; identify an offset of the offsets based on the plurality of errors; and adjust timing information of a watermark of the watermarks using the offset to increase an accuracy of the timing information.

Abstract: A shoulder immobilizer and arm apparatus are provided for enhanced comfort and ease of use for rehabilitating a shoulder. The shoulder immobilizer includes a double figure-9 strap configuration to support the weight of an injured arm and shoulder comfortably. The shoulder immobilizer can be stepped down for modular construction and use depending on a user's needs. The shoulder immobilizer may be configured to cooperate with a corresponding arm apparatus, including an open-frame sling allowing for elbow extension and a simplified strap configuration.

Abstract: A pipe fusion machine including a track mounted chassis supporting a horizontal turntable for unlimited, reversible rotation relative to the chassis. A boom pivotally attached at a rear end of, and extending forwardly of, the turntable enables manipulation of elevations and distances of the free end of the boom. The free end of the boom is adapted to permit pivotal mounting thereon of a pipe fusion tool such as an indexer configured to articulate and support a pipe-end facer and a pipe-end heater for respective independent orientation into and out of alignment with the ends of pipes to be fused. A carriage supports fixed and sliding jaws adapted to grip the ends of pipes to be fused for relative reciprocal movement during a pipe fusion process. Each of the jaws may include an upper half jaw and lower left and right quarter jaws.

Abstract: A grounding system for a rackable circuit breaker includes a finger cluster connector connected to a grounding bus in the circuit breaker and a rail conductor mounted in a circuit breaker cradle and connected to ground potential. The finger cluster connector includes a conductor formed from a single plate of conductive material folded into a generally U-shaped body with first and second sides divided into a plurality of fingers. Distal ends of the fingers form mutually facing parallel surfaces of a constricted passage configured to make a sliding electrical contact with the rail conductor that is advanced into the constricted passage as the circuit breaker is racked into the cradle. First and second leaf springs fastened to the conductor portion are divided into a plurality of spring finger sections with spring distal ends configured to respectively press against the distal ends of respective fingers of the conductor portion.

Abstract: The present disclosure relates generally to a vehicle safety system. The vehicle safety system may include operational sensors sensing operational characteristics of a vehicle, environmental sensors sensing environmental characteristics of an environment external to the vehicle, and one or more processors. The operational and environmental sensors may output operational and environmental data based on the operational and environmental characteristics that are sensed by the respective sensors. The processors may examine the operational and environmental data to determine whether the vehicle is in a safe state for an onboard operator of the vehicle to exit the vehicle while avoiding the vehicle rolling away from a stationary state. The processors may examine the operational and environmental data to determine whether the vehicle is not in the safe state and may generate one or more notifications to the operator in response to determining that the vehicle is not in the safe state.

Abstract: A system (e.g., a vehicle control system) includes a brake control unit that is configured to be operably deployed onboard a vehicle. The brake control unit has one or more sensor inputs and one or more control outputs. One of the sensor units is configured to receive a speed signal from a speed sensor of the vehicle; the speed signal is indicative of a vehicle speed detected by the speed sensor. One of the control outputs is configured for connection to a brake system of the vehicle. The brake control unit is configured to generate a vehicle control signal to initiate a vehicle brake operation responsive to the speed indicated by the speed signal going above a designated first speed threshold and the speed signal meeting one or more first designated criteria in addition to the first speed threshold.

Abstract: An electrode assembly for an electromagnetic flow meter (1; FIG. 1) is disclosed. The electrode assembly comprises a housing, which may be a flow tube (2; FIG. 1) of the electromagnetic flow meter, having a passage (123) between first and second ends (1241, 1242), an electrode (125) comprising a plug of porous material, for example formed of porous graphite, at least partially disposed within the passage proximate the first end, and an electrically-conductive polymer connector (125) at least partially disposed within the passage and in direct contact with the electrode.

Abstract: Use of (pyrophosphato)platinum(II) or platinum(IV) complexes (“phosphaplatins”), especially 1,2-cyclohexanediamine(pyrophosphato) platinum(II), as immunogenic cell death (ICD) inducing agents and their combination with immune checkpoint protein inhibitors for treatment of cancers, and the mechanistic rationale for the methods thereof, are disclosed.

Abstract: System includes a controller comprising one or more processors configured to generate alertness requests to an operator of a vehicle system during a trip. The alertness requests are generated according to a determined routine. The controller is further configured to receive reactive inputs from the operator that are responsive to the alertness requests. The controller is further configured to determine whether the trip includes a permissible route segment for suspending the determined routine. The permissible route segment has a route characteristic of one or both of: a reduced likelihood of operator-required events occurring or a predicted workload for the operator that is less than a defined workload threshold.

Abstract: Use of (pyrophosphato)platinum(II) or platinum(IV) complexes (“phosphaplatins”), especially 1,2-cyclohexanediamine(pyrophosphato) platinum(II), as immunogenic cell death (ICD) inducing agents and their combination with immune checkpoint protein inhibitors for treatment of cancers, and the mechanistic rationale for the methods thereof, are disclosed.

Abstract: Use of (pyrophosphato)platinum(II) or (pyrophosphato)platinum(IV) complexes (“phosphaplatin compounds”), especially (R,R)-1,2-cyclohexanediamine-(dihydrogen pyrophosphato)platinum(II) (or “PT-112”), as therapeutic agents for treatment of bone and blood cancers, or cancers that metastasize to bones, and methods thereof, are disclosed.

Abstract: Use of (pyrophosphato)platinum(II) or (pyrophosphato)platinum(IV) complexes (“phosphaplatin compounds”), especially (R,R)1,2-cyclohexanediamine-(dihydrogen pyrophosphato)platinum(II) (or “PT-112”), as therapeutic agents for treatment of bone and blood cancers, or cancers that metastasize to bones, and methods thereof, are disclosed.

Abstract: An aspect provides a method, including: receiving, from a wireless display device, one or more beacons using a receiver of an information handling device; using, at the information handling device, the one or more beacons to determine one or more wireless display device characteristics; initiating, at the information handling device, one of a plurality of wireless connection protocols determined based on the one or more wireless display device characteristics; establishing, using a communication module of the information handling device, a wireless connection with the wireless display device; and transmitting, with the communication module of the information handling device, data for display to the wireless display device. Other aspects are described and claimed.

Abstract: A grain harvesting articulated combine includes a forward crop processing power unit (PPU), a rear grain cart, and an articulation joint that connects the PPU with the rear grain cart. The articulation joint includes a grain auger assembly running from the PPU to the rear grain cart for transferring clean grain from the PPU to the rear grain cart and has a forward end at the PPU and a rear end adjacent to the rear grain cart. The grain auger assembly is housed within a tube with a rotating auger housed therein. A grain yield sensor is carried by the rear grain cart and is located adjacent and to and beside the grain auger assembly wherein the auger housed therewithin throws grain against the grain yield sensor. The auger is terminated by a rotating paddle assembly that throws the grain against the grain yield sensor.

Abstract: An intelligent audio/video source switcher and controller that automatically switches the input source based on a change in an incoming audio/video signal (for example, upon detection of a commercial break), devices that connect to the source switcher and controller, and methods for using the same, are presented. The switcher allows playback of media stored in memory of the switcher or streamed to the switcher via a network connection, thereby allowing commercial breaks in a television broadcast to be replaced with alternate content, such as alternate advertising or entertainment. In one or more embodiments, the apparatus of the present invention includes a control server configured to send commands to the switcher via a network to instruct the switcher to switch audio/video inputs, play back alternate media, or download media and/or software updates.